A combined in vitro-in silico method for assessing the androgenic activities of bisphenol A and its analogues DOI Creative Commons
Chang Gyun Park,

Karim Md Adnan,

Hyunki Cho

et al.

Toxicology in Vitro, Journal Year: 2024, Volume and Issue: 98, P. 105838 - 105838

Published: May 5, 2024

Interactions between endocrine-disruptor chemicals (EDCs) and androgen receptor (AR) have adverse effects on the endocrine system, leading to human reproductive dysfunction. Bisphenol A (BPA) is an EDC that can damage both environment health. Although numerous BPA analogues been produced as substitutes for BPA, few studies evaluated their endocrine-disrupting abilities. We assessed (anti)-androgenic activities of its using a yeast-based reporter assay. The tested were bisphenol S (BPS), 4-phenylphenol (4PP), 4,4′-(9-fluorenyliden)-diphenol (BPFL), tetramethyl F (TMBPF), (TMBPA). also conducted molecular docking dynamics simulations assess interactions with ligand-binding domain AR (AR-LBD). Neither nor had androgenic activity; however, all except BPFL exerted robust anti-androgenic effects. Consistent in vitro results, formed hydrogen bonding patterns key residues differed from endogenous hormones, indicating display inappropriate orientations when interacting binding pocket AR-LBD. Our findings indicate disrupt signaling by Overall, activity, which mediated AR.

Language: Английский

Exposure to phthalates and female reproductive health: A literature review DOI
Carla Giovana Basso, Anderson Tadeu de Araújo-Ramos, Anderson Joel Martino‐Andrade

et al.

Reproductive Toxicology, Journal Year: 2022, Volume and Issue: 109, P. 61 - 79

Published: March 3, 2022

Language: Английский

Citations

78
Endocrine disrupting chemicals impact on ovarian aging: Evidence from epidemiological and experimental evidence DOI
Ting Ding,

Wei Yan,

Ting Zhou

et al.

Environmental Pollution, Journal Year: 2022, Volume and Issue: 305, P. 119269 - 119269

Published: April 8, 2022

Language: Английский

Citations

76
Phthalates’ exposure leads to an increasing concern on cardiovascular health DOI Creative Commons
Melissa Mariana, Miguel Castelo-Branco, Amadeu M.V.M. Soares

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 457, P. 131680 - 131680

Published: May 23, 2023

Being an essential component in the plastics industry, phthalates are ubiquitous environment and everyday life. They considered environmental contaminants that have been classified as endocrine-disrupting compounds. Despite di-2-ethylhexyl phthalate (DEHP) being most common plasticizer studied to date, there many others that, addition widely used plastic, also applied medical pharmaceutical industries cosmetics. Due their wide use, easily absorbed by human body where they can disrupt endocrine system binding molecular targets interfering with hormonal homeostasis. Thus, exposure has implicated development of several diseases different age groups. Collecting information from recent available literature, this review aims relate phthalates’ cardiovascular throughout all ages. Overall, studies presented demonstrated association between diseases, either prenatal or postnatal exposure, affecting foetuses, infants, children, young older adults. However, mechanisms underlying these effects remain poorly explored. considering incidence worldwide constant phthalates, topic should be extensively understand involved.

Language: Английский

Citations

68
Effect of bisphenol A on the neurological system: a review update DOI Creative Commons
Henrique Eloi Costa, Elisa Cairrão

Archives of Toxicology, Journal Year: 2023, Volume and Issue: 98(1), P. 1 - 73

Published: Oct. 19, 2023

Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) and one of the most produced synthetic compounds worldwide. BPA can be found in epoxy resins polycarbonate plastics, which are frequently used food storage baby bottles. However, bind mainly to estrogen receptors, interfering with various neurologic functions, its use a topic significant concern. Nonetheless, neurotoxicity has not been fully understood despite numerous investigations on disruptive effects. Therefore, this review aims highlight recent studies implications system. Our findings suggest that exposure impairs structural molecular brain changes, promoting oxidative stress, changing expression levels several crucial genes proteins, destructive effects neurotransmitters, excitotoxicity neuroinflammation, damaged blood-brain barrier function, neuronal damage, apoptosis effects, disruption intracellular Ca

Language: Английский

Citations

68
Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review DOI Creative Commons
Maria Inês Fonseca, Margarida Lorigo, Elisa Cairrão

et al.

Journal of Xenobiotics, Journal Year: 2022, Volume and Issue: 12(3), P. 181 - 213

Published: July 13, 2022

Currently, the plastic monomer and plasticizer bisphenol A (BPA) is one of most widely used chemicals. BPA present in polycarbonate plastics epoxy resins, commonly food storage industrial or medical products. However, use this synthetic compound a growing concern, as an endocrine-disrupting can bind mainly to estrogen receptors, interfering with different functions at cardiovascular level. Several studies have investigated disruptive effects BPA; however, its cardiotoxicity remains unclear. Therefore, review’s purpose address recent on implications system. Our findings suggest that impairs cardiac excitability through intracellular mechanisms, involving inhibition main ion channels, changes Ca2+ handling, induction oxidative stress, epigenetic modifications. data support exposure increases risk developing diseases (CVDs) including atherosclerosis factors such hypertension diabetes. Furthermore, also particularly harmful pregnancy, promoting development hypertensive disorders during pregnancy. In summary, compromises human health, progression CVDs factors. Further are needed clarify health BPA-induced cardiotoxicity.

Language: Английский

Citations

58
The Effects of Bisphenol A on Human Male Infertility: A Review of Current Epidemiological Studies DOI Open Access

Mafalda Presunto,

Melissa Mariana, Margarida Lorigo

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12417 - 12417

Published: Aug. 4, 2023

Endocrine disruptor chemicals (EDCs) can have a harmful effect on the human body’s endocrine system and thus adversely affect development, reproduction, neurological, cardiovascular, immune systems metabolism in humans wildlife. According to World Health Organization, EDCs are mostly man-made found ubiquitously our daily lives, notably pesticides, metals, additives or contaminants food personal care products. Human exposure occurs through ingestion, inhalation, dermal contact. Bisphenol A (BPA) is proven EDC capable of mimicking blocking receptors altering hormone concentrations metabolism. Although consumed low doses, it stimulate cellular responses functions. In humans, BPA has been correlated with onset development several diseases. This literature review aimed verify effects male infertility using most recently published literature. Thus, this allowed us conclude that compound seems fertility, causing changes hormonal semen characteristics. However, these conclusions lack more robust reproducible scientific studies. Even so, since prevalence increasing, preventive measures must be taken ensure fertility.

Language: Английский

Citations

31
Structural insight into the mechanisms and interacting features of endocrine disruptor Bisphenol A and its analogs with human estrogen-related receptor gamma DOI Creative Commons
Rajesh Kumar Pathak, Jun‐Mo Kim

Environmental Pollution, Journal Year: 2024, Volume and Issue: 345, P. 123549 - 123549

Published: Feb. 11, 2024

Bisphenol A (BPA) is a very important chemical from the commercial perspective. Many useful products are made it, so its production increasing day by day. It widely known that and analogs present in environment they enter our body through various routes on daily basis as we use things of this lives. BPA has already been reported to be an endocrine disruptor. Studies have shown binds strongly human estrogen-related receptor gamma (ERRγ) target it. This study seeks understand how it interacts with ERRγ. Molecular docking ERRγ was performed, estradiol taken reference. Then, physico-chemical toxicological analysis compounds performed. Subsequently, dynamic behavior ERRγ-BPA compound complexes studied molecular dynamics simulations over 500 ns, using simulated data, their binding energies were again calculated MM-PBSA method. We observed affinity much higher than estradiol, apart being toxic, can easily absorbed physicochemical properties similar those oral medicines. Therefore, facilitates understanding structure–activity relationship provides information about key amino acid residues interact compounds, which helpful design competitive inhibitors interrupt interaction In addition, will also developing new therapeutics.

Language: Английский

Citations

9
Co-exposure to phthalates and polycyclic aromatic hydrocarbons and the risk of gestational hypertension in Chinese women DOI Creative Commons
Xiaowen Liu,

Jigen Na,

Xiaojing Liu

et al.

Environment International, Journal Year: 2024, Volume and Issue: 185, P. 108562 - 108562

Published: March 1, 2024

Phthalates (PAEs) and polycyclic aromatic hydrocarbons (PAHs) are frequently detected in females of reproductive age. Many studies have found that environmental PAE PAH levels independent risk factors for gestational hypertension. However, exposure to both components is a more realistic scenario. To better assess the health effects PAEs PAHs pregnant women, we explored associations individual combined with This nested case-control study was component prospective cohort conducted Beijing, China. We included 206 women hypertension 214 controls. used gas chromatography/tandem mass spectrometry (GC-MS/MS) detect 8 13 > 80 % all collected hair samples. Multiple linear regression models were employed test between each A quantile-based g-computation (qgcomp) model weighted quantile sum (WQS) estimate whether increased The analyses revealed diethyl phthalate (DEP), diisobutyl (DIBP) (both PAEs), benzo(k)fluoranthene (BKF), anthracene, (ANT), benzo(a)pyrene (BAP) (all PAHs) positively associated In mixed-effect analyses, qgcomp indicated co-exposure (odds ratio = 2.01; 95 confidence interval: 1.02, 3.94); this finding verified by WQS model. Our findings support earlier evidence increase hypertension, individually combination. suggests reductions endocrine system-disrupting chemicals such as might reduce

Language: Английский

Citations

8
Exposure to UV-B filter octylmethoxycinnamate and human health effects: Focus on endocrine disruptor actions DOI Creative Commons
Margarida Lorigo, Carla Quintaneiro, Luiza Breitenfeld

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 358, P. 142218 - 142218

Published: May 2, 2024

Human skin is the first line of photoprotection against UV radiation. However, despite having its defence mechanisms, that exerts not enough. To protect human skin, inclusion filters in cosmetic industry has grown significantly as a strategy. Octylmethoxycinnamate, also designated by octinoxate, or 2-ethylhexyl-4-methoxycinnamate (CAS number: 5466-77-3) one most widely used UV-B filter industry. The toxic effects OMC have alarmed public, but there still no consensus scientific community about use. This article aims to provide an overview filters' photoprotection, emphasizing and possible negative it may on public health. Moreover, current legislation will be addressed. In summary, recommendations should rethought assess their risk-benefit, since existing literature warns us endocrine-disrupting OMC. Further studies focus toxicity alone, mixture consider degradation products, improve knowledge risk assessment EDC.

Language: Английский

Citations

6
Effects of BPA substitutes on the prenatal and cardiovascular systems DOI
Fatima Abrantes-Soares, Margarida Lorigo, Elisa Cairrão

et al.

Critical Reviews in Toxicology, Journal Year: 2022, Volume and Issue: 52(6), P. 469 - 498

Published: July 3, 2022

Bisphenol A (BPA) is a ubiquitous chemical compound constantly being released into the environment, making it one of most persistent endocrine-disrupting (EDC) in nature. This EDC has already been associated with developing various pathologies, such as diabetes, obesity, and cardiovascular, renal, behavioral complications, among others. Therefore, over years, BPA replaced, gradually, by its analog compounds. However, these compounds are structurally similar to BPA, so, recent questions have raised concerning their safety for human health. Numerous investigations performed determine effects substitutes may cause, particularly during pregnancy prenatal life. On other hand, studies investigating association development cardiovascular diseases (CVD) developed. In this sense, review summarizes existing literature on transgenerational transfer consequent maternal offspring health following exposure. addition, compounds’ system susceptibility develop CVD will be presented. aims highlight need investigate further benefits, or hazards, replacing analogs.

Language: Английский

Citations

23