Photon-Controlled Pyroptosis Activation (PhotoPyro): An Emerging Trigger for Antitumor Immune Response

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(11), P. 6007 - 6023

Published: March 7, 2023

Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD) characterized by release pro-inflammatory cytokines. Our knowledge pyroptosis has expanded beyond cellular level and now includes extracellular responses. In recent years, attracted considerable attention due its potential induce host immunity. For instance, at 2022 International Medicinal Chemistry Natural Active Ligand Metal-Based Drugs (MCNALMD) conference, numerous researchers demonstrated an interest in photon-controlled activation ("PhotoPyro"), emerging pyroptosis-engineered approach for activating systemic immunity via photoirradiation. Given this enthusiasm, we share Perspective our views on area expound how why "PhotoPyro" could trigger antitumor (i.e., turning so-called "cold" tumors "hot"). doing so, have tried highlight cutting-edge breakthroughs PhotoPyro while suggesting areas future contributions. By providing insights into current state art serving as a resource individuals interested working area, it is hoped that will set stage evolve broadly applicable cancer treatment strategy.

Language: Английский

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Self‐Destructive Copper Carriers Induce Pyroptosis and Cuproptosis for Efficient Tumor Immunotherapy Against Dormant and Recurrent Tumors

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(8)

Published: Oct. 11, 2023

Abstract Activating the strong immune system is a key initiative to counteract dormant tumors and prevent recurrence. Herein, self‐destructive multienzymatically active copper‐quinone‐GOx nanoparticles (abbreviated as CQG NPs) have been designed induce harmonious balanced pyroptosis cuproptosis using “Tai Chi mindset” awaken response for suppressing recurrent tumors. This cleverly material can disrupt antioxidant defense mechanism of tumor cells by inhibiting nuclear factor‐erythroid 2‐related factor 2 (NRF2)‐quinone oxidoreductase 1 (NQO1) signaling pathway. Furthermore, combined with its excellent multienzyme activity, it activates NOD‐like receptor protein 3 (NLRP3)‐mediated pyroptosis. Meanwhile, be triggered copper ions released from disintegration NPs sensitivity cancer enhanced through depletion endogenous chelators via Michael addition reaction between glutathione (GSH) quinone ligand, oxygen production catalase‐like reaction, starvation‐induced glucose deficiency. More importantly, NPs‐induced promote immunosuppressive microenvironment (TME) remodeling, enhance infiltration into tumor, activate robust systemic immunity. Collectively, this study provides new strategy resist dormancy, recurrence, improve clinical prognosis

Language: Английский

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Nanofarming: Promising Solutions for the Future of the Global Agricultural Industry

Agronomy, Journal Year: 2023, Volume and Issue: 13(6), P. 1600 - 1600

Published: June 13, 2023

The agricultural sector is a vital source of human well-being that provides the necessities daily life. A variety farming systems are utilized in agriculture, such as wide range tillage options, no-till, agroforestry, precision farming, organic cover cropping, crop rotations, etc. Each these has unique challenges, and nanotechnology successfully improved on many them. Agricultural applications include nanofertilizers, nanopesticides, nanosensors, nanobiotechnology, nanoremediation. This study focuses application nano-farming technologies to different systems. Suggested practices nano improvement soil quality, nano-protection under biotic stress, nanoremediation polluted water environments, nanomanagement agro-wastes, nano-agrochemicals, nano-precision nanobiotechnology for modern farming. review also addresses expected problems may occur due over nanomaterials systems, nanopollution nanotoxicity agroecosystem compartments. Several dimensions emphasized this study, green energy, sustainable development, circular bioeconomy, land biodegradation, pollution, one health approach, essential global goals development. Nanofarming presents both benefits obstacles exact balance between challenges needs more study.

Language: Английский

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Copper‐Bacteriochlorin Nanosheet as a Specific Pyroptosis Inducer for Robust Tumor Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(44)

Published: July 8, 2023

Pyroptosis is increasingly considered a new weathervane in cancer immune therapy. However, triggering specific pyroptotic tumor cell death while preserving normal cells still remains major challenge. Herein, brand-new pyroptosis inducer, copper-bacteriochlorin nanosheet (Cu-TBB), designed. The synthesized Cu-TBB can be activated to an "on" state the microenvironment with glutathione (GSH) overexpression, leading release of Cu+ and TBB, respectively. Intriguingly, released drive cascade reactions produce O2-• highly toxic ·OH cells. Additionally, TBB also generate 1 O2 upon 750 nm laser irradiation. Encouragingly, both -driven photodynamic therapy pathways result potent along dendritic maturation T priming, thus simultaneously eliminating primary tumors inhibiting distant growth metastases. Conclusively, well-designed shown trigger vitro vivo, enhanced immunogenicity antitumor efficacy minimizing systemic side effects.

Language: Английский

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A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Language: Английский

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Oxygen‐carrying semiconducting polymer nanoprodrugs induce sono‐pyroptosis for deep‐tissue tumor treatment

Exploration, Journal Year: 2024, Volume and Issue: 4(4)

Published: Feb. 19, 2024

Abstract Sonodynamic therapy (SDT) has been explored for cancer therapy, especially deep tumors due to its low tissue penetration restriction. The therapeutic efficacy of SDT is limited the complicated tumor microenvironment. This study reports construction oxygen‐carrying semiconducting polymer nanoprodrugs (OSPN pro ) treatment via combining amplified with pyroptosis. An oxygen carrier perfluorohexane, sonodynamic as sonosensitizer, and reactive species (ROS)‐responsive prodrug are co‐loaded into a nanoparticle system, leading formation these nanoprodrugs. Such OSPN show an effective accumulation in tissues after systemic administration, which they deliver relieve hypoxia microenvironment thus mediate producing ROS under ultrasound (US) irradiation, even when covered 2‐cm chicken breast tissue. In addition, ROS‐responsive prodrugs activated by generated trigger pyroptosis cells. sono‐pyroptosis induces strong antitumor immunity obviously higher level infiltrations effector immune cells tumors. Therefore, ‐based combinational can greatly inhibit growth tissue‐covered suppress metastasis. offers nanoplatform strategy.

Language: Английский

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Wrecking neutrophil extracellular traps and antagonizing cancer-associated neurotransmitters by interpenetrating network hydrogels prevent postsurgical cancer relapse and metastases

Bioactive Materials, Journal Year: 2024, Volume and Issue: 39, P. 14 - 24

Published: May 14, 2024

Tumor-promoting niche after incomplete surgery resection (SR) can lead to more aggressive local progression and distant metastasis with augmented angiogenesis-immunosuppressive tumor microenvironment (TME). Herein, elevated neutrophil extracellular traps (NETs) cancer-associated neurotransmitters (CANTs, e.g., catecholamines) are firstly identified as two of the dominant inducements. Further, an injectable fibrin-alginate hydrogel high tissue adhesion has been constructed specifically co-deliver NETs inhibitor (DNase I)-encapsulated PLGA nanoparticles unselective β-adrenergic receptor blocker (propranolol). The components (i.e., fibrin alginate) respond triggers (thrombin Ca2+, respectively) in postoperative bleeding gelate, shaping into interpenetrating network (IPN) featuring strength. continuous release DNase I PR wreck antagonize catecholamines decrease microvessel density, blockade myeloid-derived suppressor cells, secrete various proinflammatory cytokines, potentiate natural killer cell function hamper cytotoxic T exhaustion. reprogrammed TME significantly suppress locally residual tumors, induce strong immune memory effects thus inhibit lung metastasis. Thus, targetedly degrading blocking CANTs enabled by this in-situ IPN-based drug depot provides a simple efficient approach against SR-induced cancer recurrence

Language: Английский

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Self-Cascaded Pyroptosis-STING Initiators for Catalytic Metalloimmunotherapy

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Gasdermin (GSDM)-mediated pyroptosis involves the induction of mitochondrial damage and subsequent release DNA (mtDNA), which is anticipated to activate cGAS-STING pathway, thereby augmenting antitumor immune response. However, challenges lie in effectively triggering cancer cells subsequently enhancing activation with specificity. Herein, we developed intelligent self-cascaded pyroptosis-STING initiators cobalt fluoride (CoF2) nanocatalysts for catalytic metalloimmunotherapy. CoF2 a semiconductor structure enzyme-like activity generated substantial amount reactive oxygen species (ROS) under stimulation by endogenous H2O2 exogenous ultrasound. Importantly, discovered that Co-based nanomaterials themselves induce cells. Therefore, initially acted as inducers, caspase-1/GSDMD-dependent via Co2+ ROS, leading mtDNA release. Subsequently, were further utilized STING agonists specifically capable detecting pathway. These cascade events triggered robust response, modulating immunosuppressive tumor microenvironment into an immune-supportive state, providing favorable support therapy. This innovative strategy not only significantly impeded growth primary but also elicited response augment efficacy checkpoint inhibitors preventing distant progression. Overall, this study proposed self-cascade activating amplifying pathway specificity mediated pyroptosis, representing valuable avenue future

Language: Английский

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Nanomedicine-Unlocked Radiofrequency Dynamic Therapy Dampens Incomplete Radiofrequency Ablation-Arised Immunosuppression to Suppress Cancer Relapse

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123087 - 123087

Published: Jan. 2, 2025

Language: Английский

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Dual‐Pronged Attack: pH‐Driven Membrane‐Anchored NIR Dual‐Type Nano‐Photosensitizer Excites Immunogenic Pyroptosis and Sequester Immune Checkpoint for Enhanced Prostate Cancer Photo‐Immunotherapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(28)

Published: Aug. 6, 2023

Prostate cancer (PCa) is a frustrating immunogenic "cold" tumor and generally receives unsatisfied immunotherapy outcomes in the clinic. Pyroptosis an excellent cell death form that can effectively activate antitumor immune response, promote cytotoxic T-lymphocyte infiltration, convert tumors from to "hot." However, vivo application of pyroptosis drugs seriously limited, upregulation PD-L1 caused by photo-immunotherapy further promotes escape. Herein, new nano-photosensitizer (YBS-BMS NPs-RKC) with pH-response integrating induction checkpoint blockade developed. The pH-responsive polymer equipped membrane anchoring peptide RKC used as carrier encapsulated near-infrared-activated semiconductor photosensitizer YBS PD-1/PD-L1 complex small molecule inhibitor BMS-202. pH-driven membrane-anchoring activation YBS-BMS NPs-RKC clearly demonstrated. In vitro studies have shown this dual-pronged therapy stimulates powerful response suppress primary progression evokes long-term memory inhibit relapse metastasis. This work provides effective self-synergistic platform for PCa idea developing more biocompatible photo-controlled inducers.

Language: Английский

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