Progress in Organic Coatings, Journal Year: 2023, Volume and Issue: 176, P. 107390 - 107390
Published: Jan. 7, 2023
Language: Английский
Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 350, P. 175 - 192
Published: Aug. 19, 2022
Language: Английский
Citations
160
Advanced Materials, Journal Year: 2020, Volume and Issue: 33(2)
Published: Nov. 30, 2020
Abstract Infectious or immune diseases have caused serious threat to human health due their complexity and specificity, emerging drug delivery systems (DDSs) evolved into the most promising therapeutic strategy for drug‐targeted therapy. Various mesoporous biomaterials are exploited applied as efficient nanocarriers loading drugs by virtue of large surface area, high porosity, prominent biocompatibility. Nanosized show great potential in biomedical research, it has become research hotspot interdisciplinary field. Herein, recent progress assembly mechanisms on inorganic (e.g., silica, carbon, metal oxide) summarized systematically, typical functionalization methods (i.e., hybridization, polymerization, doping) also discussed depth. Particularly, structure–activity relationship effect physicochemical parameters biomaterials, including morphologies hollow, core–shell), pore textures size, volume), features roughness hydrophilic/hydrophobic) DDS application overviewed elucidated detail. As one important development directions, advanced stimuli‐responsive DDSs pH, temperature, redox, ultrasound, light, magnetic field) highlighted. Finally, prospect disease therapeutics is stated, will open a new spring nanocarriers.
Language: Английский
Citations
146
Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 351, P. 50 - 80
Published: Sept. 20, 2022
The site-specific delivery of antitumor agents is importance for providing effective cancer suppression. Poor bioavailability anticancer compounds and the presence biological barriers prevent their accumulation in tumor sites. These obstacles can be overcome using liposomal nanostructures. challenges chemotherapy stimuli-responsive nanocarriers are first described current review. Then, liposomes including pH-, redox-, enzyme-, light-, thermo- magneto-sensitive nanoparticles discussed potential drugs emphasized. pH- or redox-sensitive based on internal stimulus release drug response to a mildly acidic pH GSH, respectively. pH-sensitive mediate endosomal escape via proton sponge. multifunctional responsive both redox have more capacity at site compared alone. magnetic field NIR irradiation exploited external stimulation liposomes. light-responsive when they exposed irradiation; thermosensitive-liposomes temperature >40 °C there hyperthermia; magneto-responsive field. smart nanoliposomes also co-delivery genes synergistic therapy. Due lack long-term toxicity liposomes, utilized near future treatment patients.
Language: Английский
Citations
124
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 490, P. 215208 - 215208
Published: May 18, 2023
Language: Английский
Citations
122
Microporous and Mesoporous Materials, Journal Year: 2022, Volume and Issue: 335, P. 111670 - 111670
Published: Jan. 3, 2022
Language: Английский
Citations
117
ACS Applied Bio Materials, Journal Year: 2021, Volume and Issue: 4(6), P. 5106 - 5121
Published: May 8, 2021
A one-pot and facile method with assistance of high gravity was applied for the synthesis inorganic two-dimensional MOF-5 embedded MXene nanostructures. The innovative MXene/MOF-5 nanostructure in co-delivery drug gene, to increase its bioavailability interaction pCRISPR, nanomaterial coated alginate chitosan. polymer-coated nanosystems were fully characterized, sustained DOX delivery comprehensive cytotoxicity studies conducted on HEK-293, PC12, HepG2, HeLa cell lines, demonstrating acceptable excellent viability at both very low (0.1 μg.mL-1) (10 μg·mL-1) concentrations. chitosan-coated nanocarriers showed superior relative compared others, more than 60% average all lines. Then, alginate-coated ranked second place higher viability, 50% Also, MTT results a complete dose-dependence, by increasing time treatment from 24 72 h, decreased meaningful slope; however, this decrease optimized coating nanocarrier chitosan alginate. also tagged pCRISPR analyze potential application drug/gene. CLSM images HEK-293 lines unveiled successful into cells, enhanced green fluorescent protein (EGFP) reached up ca. 26% line. considerable payload 35.7% achieved, which would be because interactions between doxorubicin. In unprecedented report pertaining assisted MOF high-gravity technique, methodology ensuing can further developed drug/gene animal models.
Language: Английский
Citations
114
ACS Applied Bio Materials, Journal Year: 2022, Volume and Issue: 5(3), P. 1305 - 1318
Published: Feb. 24, 2022
Cancer is a deadly disease that has long plagued humans and become more prevalent in recent years. The common treatment modalities for this have always faced many problems complications, led to the discovery of strategies cancer diagnosis treatment. use magnetic nanoparticles past two decades had significant impact on this. One objectives present study introduce special properties these how they are structured load transport drugs tumors. In study, iron oxide (Fe3O4) with 6 nm sizes were coated hyperbranched polyglycerol (HPG) folic acid (FA). functionalized (10-20 nm) less likely aggregate compared non-functionalized nanoparticles. HPG@Fe3O4 FA@HPG@Fe3O4 drug loading procedures curcumin. nanoparticles' maximal drug-loading capacities determined be 82 88%, respectively. HeLa cells mouse L929 fibroblasts treated took up than produced current investigation potential as anticancer delivery systems. For purpose diagnosis, incubation decreased MRI signal enhancement's percentage largest alteration was observed after
Language: Английский
Citations
90
RSC Advances, Journal Year: 2023, Volume and Issue: 13(31), P. 21365 - 21382
Published: Jan. 1, 2023
This review focuses on the research progress of various receptors overexpressed surface cancer cells and different nano-delivery systems anticancer drugs targeted cells.
Language: Английский
Citations
57
Small, Journal Year: 2024, Volume and Issue: 20(35)
Published: May 1, 2024
Abstract Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art nanovaccine development, elucidating innovative strategies and technologies employed their design. It explores both preclinical clinical advancements, emphasizing key studies demonstrating potential elicit robust anti‐tumor immune responses. The study encompasses various facets, including integrating biomaterial‐based nanocarriers for antigen delivery, adjuvant selection, impact of nanoscale properties on performance. Detailed insights into complex interplay between tumor microenvironment responses are provided, highlighting challenges opportunities optimizing therapeutic outcomes. Additionally, presents thorough analysis ongoing trials, presenting snapshot landscape. By curating latest scientific findings developments, this aims serve as comprehensive resource researchers clinicians engaged advancing immunotherapy. Integrating design holds immense promise revolutionizing treatment paradigms, provides timely update evolving landscape nanovaccines.
Language: Английский
Citations
24
Journal of Polymers and the Environment, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 11, 2025
Language: Английский
Citations
3