Polyunsaturated fatty acids and their metabolites in brain function and disease

Nature reviews. Neuroscience, Journal Year: 2014, Volume and Issue: 15(12), P. 771 - 785

Published: Nov. 12, 2014

Language: Английский

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Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(3), P. 833 - 833

Published: March 13, 2018

The biological effects of cannabinoids, the major constituents ancient medicinal plant Cannabis sativa (marijuana) are mediated by two members G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2. CB1R is prominent subtype in central nervous system (CNS) has drawn great attention as a potential therapeutic avenue several pathological conditions, including neuropsychological disorders neurodegenerative diseases. Furthermore, cannabinoids also modulate signal transduction pathways exert profound at peripheral sites. Although have potential, their psychoactive largely limited use clinical practice. In this review, we briefly summarized our knowledge endocannabinoid system, focusing on CNS, with emphasis recent breakthroughs field. We aim to define roles modulation signaling association pathophysiological conditions. believe that significance masked adverse here alternative strategies discussed take advantage cannabinoids.

Language: Английский

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An Introduction to the Endogenous Cannabinoid System

Biological Psychiatry, Journal Year: 2015, Volume and Issue: 79(7), P. 516 - 525

Published: Nov. 3, 2015

Language: Английский

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Hippocampal GABAergic Inhibitory Interneurons

Physiological Reviews, Journal Year: 2017, Volume and Issue: 97(4), P. 1619 - 1747

Published: Sept. 28, 2017

In the hippocampus GABAergic local circuit inhibitory interneurons represent only ~10–15% of total neuronal population; however, their remarkable anatomical and physiological diversity allows them to regulate virtually all aspects cellular function. Here we provide an overview current state field interneuron research, focusing largely on hippocampus. We discuss recent advances related various cell types, including development maturation, expression subtype-specific voltage- ligand-gated channels, roles in network oscillations. also technological approaches that have permitted high-resolution, examination numerous neural disorders emerging therapeutic strategies ameliorate such pathophysiological conditions. The ultimate goal this review is not a touchstone for field, but help pave way future research by highlighting where gaps our knowledge exist how complete appreciation will aid strategies.

Language: Английский

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Cannabidiol as a Potential Treatment for Anxiety Disorders

Neurotherapeutics, Journal Year: 2015, Volume and Issue: 12(4), P. 825 - 836

Published: Sept. 4, 2015

Language: Английский

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Acute and Chronic Effects of Cannabinoids on Human Cognition—A Systematic Review

Biological Psychiatry, Journal Year: 2015, Volume and Issue: 79(7), P. 557 - 567

Published: Dec. 12, 2015

Language: Английский

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The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(9), P. 4971 - 4982

Published: Feb. 19, 2020

Parkinson’s disease (PD) is characterized by the accumulation of misfolded and aggregated α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it widely believed that α-syn plays a central role in pathogenesis PD, processes govern fibrillization LB formation remain poorly understood. In this work, we sought to dissect spatiotemporal events involved biogenesis LBs at genetic, molecular, biochemical, structural, cellular levels. Toward goal, further developed seeding-based model generate neuronal reproduces key leading formation, including seeding, fibrillization, recapitulate many organizational features bona fide LBs. Using an integrative omics, biochemical imaging approach, dissected molecular associated with different stages their contribution dysfunction degeneration. addition, demonstrate involves complex interplay between posttranslational modifications, interactions aggregates membranous organelles, mitochondria, autophagosome, endolysosome. Finally, show process rather than simply fibril one major drivers neurodegeneration through disruption functions inducing mitochondria damage deficits, synaptic dysfunctions. We believe represents powerful platform investigate mechanisms clearance screen evaluate therapeutics targeting aggregation formation.

Language: Английский

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Projections from neocortex mediate top-down control of memory retrieval

Nature, Journal Year: 2015, Volume and Issue: 526(7575), P. 653 - 659

Published: Oct. 1, 2015

Language: Английский

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The endocannabinoid system in guarding against fear, anxiety and stress

Nature reviews. Neuroscience, Journal Year: 2015, Volume and Issue: 16(12), P. 705 - 718

Published: Nov. 20, 2015

Language: Английский

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From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology

Physiological Reviews, Journal Year: 2016, Volume and Issue: 96(4), P. 1593 - 1659

Published: Sept. 15, 2016

Apart from having been used and misused for at least four millennia for, among others, recreational medicinal purposes, the cannabis plant its most peculiar chemical components, cannabinoids (phytocannabinoids), have merit to led humanity discover one of intriguing pleiotropic endogenous signaling systems, endocannabinoid system (ECS). This review article aims describe critically discuss, in comprehensive possible manner, multifaceted aspects 1) pharmacology potential impact on mammalian physiology all major phytocannabinoids, not only famous Δ 9 -tetrahydrocannabinol, 2) adaptive pro-homeostatic physiological, or maladaptive pathological, roles ECS cells, tissues, organs. In doing so, we respected chronological order milestones millennial route medicinal/recreational beyond, as it is now clear that some early steps this long path, which were originally neglected, are becoming important again. The emerging picture rather complex, but still supports belief more discoveries human physiology, new therapies, might come future knowledge field.

Language: Английский

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