Constructing an adult orofacial premotor atlas in Allen mouse CCF DOI Creative Commons
Jun Takatoh, Jae Hong Park, Jinghao Lu

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: April 27, 2021

Premotor circuits in the brainstem project to pools of orofacial motoneurons execute essential motor action such as licking, chewing, breathing, and rodent, whisking. Previous transsynaptic tracing studies only mapped premotor neonatal mice, but adult remain unknown a consequence technical difficulties. Here, we developed three-step monosynaptic strategy identify neurons controlling vibrissa, tongue protrusion, jaw-closing muscles mouse. We registered these different groups onto Allen mouse brain common coordinate framework (CCF) consequently generated combined 3D atlas, revealing unique spatial organizations distinct circuits. further uncovered that simultaneously innervate multiple nuclei and, consequently, are likely involved same actions. Our method for registering CCF is generally applicable should facilitate investigations controls diverse behaviors.

Language: Английский

Sensorimotor processing in the rodent barrel cortex DOI
Carl C.H. Petersen

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(9), P. 533 - 546

Published: July 31, 2019

Language: Английский

Citations

235
Breathing Rhythm and Pattern and Their Influence on Emotion DOI Open Access
Sufyan Ashhad, Kaiwen Kam, Christopher A. Del Negro

et al.

Annual Review of Neuroscience, Journal Year: 2022, Volume and Issue: 45(1), P. 223 - 247

Published: March 9, 2022

Breathing is a vital rhythmic motor behavior with surprisingly broad influence on the brain and body. The apparent simplicity of breathing belies complex neural control system, central pattern generator (bCPG), that exhibits diverse operational modes to regulate gas exchange coordinate an array behaviors. In this review, we focus selected advances in our understanding bCPG. At core bCPG preBötzinger (preBötC), which drives inspiratory rhythm via unexpectedly sophisticated emergent mechanism. Synchronization dynamics underlying preBötC rhythmogenesis imbue system robustness lability. These are modulated by inputs from throughout generate rhythmic, patterned activity widely distributed. connectivity emerging literature support link between breathing, emotion, cognition becoming experimentally tractable. bring great potential for elucidating function dysfunction other mammalian circuits.

Language: Английский

Citations

88
Motor cortex — to act or not to act? DOI
Christian L. Ebbesen, Michael Brecht

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(11), P. 694 - 705

Published: Oct. 18, 2017

Language: Английский

Citations

141
Mapping cortical mesoscopic networks of single spiking cortical or sub-cortical neurons DOI Creative Commons
Dongsheng Xiao, Matthieu P. Vanni, Catalin Mitelut

et al.

eLife, Journal Year: 2017, Volume and Issue: 6

Published: Feb. 4, 2017

Understanding the basis of brain function requires knowledge cortical operations over wide-spatial scales, but also within context single neurons. In vivo, wide-field GCaMP imaging and sub-cortical/cortical cellular electrophysiology were used in mice to investigate relationships between spontaneous neuron spiking mesoscopic activity. We make use a rich set activity motifs that are present anesthetized awake animals. A mesoscale spike-triggered averaging procedure allowed identification preferentially linked individual neurons by employing genetically targeted indicators neuronal Thalamic predicted reported specific cycles wide-scale inhibition/excitation. contrast, maps derived from yielded spatio-temporal expected for regional consensus function. This approach can define network any point source maps.

Language: Английский

Citations

137
Bidirectional learning in upbound and downbound microzones of the cerebellum DOI
Chris I. De Zeeuw

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 22(2), P. 92 - 110

Published: Nov. 17, 2020

Language: Английский

Citations

119
Active Touch and Self-Motion Encoding by Merkel Cell-Associated Afferents DOI Creative Commons
Kyle S. Severson, Duo Xu,

Margaret Van de Loo

et al.

Neuron, Journal Year: 2017, Volume and Issue: 94(3), P. 666 - 676.e9

Published: April 20, 2017

Language: Английский

Citations

116
Movement Initiation Signals in Mouse Whisker Motor Cortex DOI Creative Commons
Varun Sreenivasan, Vahid Esmaeili,

Taro Kiritani

et al.

Neuron, Journal Year: 2016, Volume and Issue: 92(6), P. 1368 - 1382

Published: Dec. 1, 2016

Frontal cortex plays a central role in the control of voluntary movements, which are typically guided by sensory input. Here, we investigate function mouse whisker primary motor (wM1), frontal region defined dense innervation from somatosensory (wS1). Optogenetic stimulation wM1 evokes rhythmic protraction (whisking), whereas optogenetic inactivation suppresses initiation whisking. Whole-cell membrane potential recordings and silicon probe action potentials reveal layer-specific neuronal activity at movement initiation, encoding fast slow parameters movements during Interestingly, wS1 caused hyperpolarization reduced firing wM1, together with drove complex dynamics, as well evoking long-latency, wM1-dependent Our results advance understanding well-defined point to an important for input controlling cortex.

Language: Английский

Citations

107
The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time DOI
Jan‐Marino Ramirez, Nathan A. Baertsch

Annual Review of Neuroscience, Journal Year: 2018, Volume and Issue: 41(1), P. 475 - 499

Published: May 1, 2018

Rhythmicity is a universal timing mechanism in the brain, and rhythmogenic mechanisms are generally dynamic. This illustrated for neuronal control of breathing, behavior that occurs as one-, two-, or three-phase rhythm. Each breath assembled stochastically, increasing evidence suggests each phase can be generated independently by dedicated excitatory microcircuit. Within microcircuit, rhythmicity emerges through three entangled mechanisms: ( a) glutamatergic transmission, which amplified b) intrinsic bursting opposed c) concurrent inhibition. triangle dynamically tuned neuromodulators other network interactions. The ability coupled oscillators to reconfigure recombine may allow breathing remain robust yet plastic enough conform nonventilatory behaviors such vocalization, swallowing, coughing. Lessons learned from respiratory translate highly dynamic integrated rhythmic systems, if approached one at time.

Language: Английский

Citations

103
Coordination of Orofacial Motor Actions into Exploratory Behavior by Rat DOI Creative Commons

Anastasia Kurnikova,

Jeffrey D. Moore,

Song-Mao Liao

et al.

Current Biology, Journal Year: 2017, Volume and Issue: 27(5), P. 688 - 696

Published: Feb. 16, 2017

Language: Английский

Citations

101
More than Just a “Motor”: Recent Surprises from the Frontal Cortex DOI Creative Commons
Christian L. Ebbesen, Michele N. Insanally, Charles D. Kopec

et al.

Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 38(44), P. 9402 - 9413

Published: Oct. 31, 2018

Motor and premotor cortices are crucial for the control of movements. However, we still know little about how these areas contribute to higher-order motor control, such as deciding which movements make when them. Here focus on rodent studies review recent findings, suggest that-in addition control-neurons in play a role sensory integration, behavioral strategizing, working memory, decision-making. We that seemingly disparate functions may subserve an evolutionarily conserved sensorimotor cognition further study could major contribution our understanding evolution function mammalian frontal cortex.

Language: Английский

Citations

93