Cell Reports,
Journal Year:
2018,
Volume and Issue:
25(1), P. 1 - 9.e5
Published: Oct. 1, 2018
Circadian
clock
dysfunction
is
a
common
symptom
of
aging
and
neurodegenerative
diseases,
though
its
impact
on
brain
health
poorly
understood.
Astrocyte
activation
occurs
in
response
to
diverse
insults
plays
critical
role
disease.
We
report
that
the
core
circadian
protein
BMAL1
regulates
astrogliosis
synergistic
manner
via
cell-autonomous
mechanism
lesser
non-cell-autonomous
signal
from
neurons.
Astrocyte-specific
Bmal1
deletion
induces
astrocyte
inflammatory
gene
expression
vitro
vivo,
mediated
part
by
suppression
glutathione-S-transferase
signaling.
Functionally,
loss
astrocytes
promotes
neuronal
death
vitro.
Our
results
demonstrate
function
elucidating
which
could
influence
many
aspects
neurological
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: Sept. 2, 2020
The
glymphatic
system
is
a
network
of
perivascular
spaces
that
promotes
movement
cerebrospinal
fluid
(CSF)
into
the
brain
and
clearance
metabolic
waste.
This
transport
supported
by
water
channel
aquaporin-4
(AQP4)
localized
to
vascular
endfeet
astrocytes.
more
effective
during
sleep,
but
whether
sleep
timing
function
remains
unknown.
We
here
show
influx
exhibit
endogenous,
circadian
rhythms
peaking
mid-rest
phase
mice.
Drainage
CSF
from
cisterna
magna
lymph
nodes
exhibits
daily
variation
opposite
influx,
suggesting
distribution
throughout
animal
depends
on
time-of-day.
polarization
AQP4
highest
rest
loss
eliminates
day-night
difference
in
both
drainage
nodes.
conclude
under
control
supports
this
rhythm.
Genome Medicine,
Journal Year:
2019,
Volume and Issue:
11(1)
Published: Dec. 1, 2019
Abstract
Circadian
clocks
are
endogenous
oscillators
that
control
24-h
physiological
and
behavioral
processes.
The
central
circadian
clock
exerts
over
myriad
aspects
of
mammalian
physiology,
including
the
regulation
sleep,
metabolism,
immune
system.
Here,
we
review
advances
in
understanding
genetic
sleep
through
system,
as
well
impact
dysregulated
gene
expression
on
metabolic
function.
We
also
recent
studies
have
begun
to
unravel
clock’s
role
controlling
cardiovascular
nervous
systems,
gut
microbiota,
cancer,
aging.
Such
these
systems
relies,
part,
transcriptional
regulation,
with
evidence
for
genome-wide
chromosome
organization.
These
novel
insights
into
genomic
human
physiology
provide
opportunities
discovery
improved
treatment
strategies
new
biological
underpinnings
disease.
Journal of Molecular Endocrinology,
Journal Year:
2019,
Volume and Issue:
63(4), P. R93 - R102
Published: Sept. 26, 2019
The
mammalian
circadian
clock
has
evolved
as
an
adaptation
to
the
24-h
light/darkness
cycle
on
earth.
Maintaining
cellular
activities
in
synchrony
with
of
organism
(such
eating
and
sleeping)
helps
different
tissue
organ
systems
coordinate
optimize
their
performance.
full
extent
mechanisms
by
which
cells
maintain
are
still
under
investigation,
but
involve
a
core
set
genes
that
regulate
large
networks
gene
transcription
both
direct
transcriptional
activation/repression
well
recruitment
proteins
modify
chromatin
states
more
broadly.
Science,
Journal Year:
2019,
Volume and Issue:
363(6423), P. 187 - 192
Published: Jan. 11, 2019
Circadian
(~24-hour)
rhythms
depend
on
intracellular
transcription-translation
negative
feedback
loops
(TTFLs).
How
these
self-sustained
cellular
clocks
achieve
multicellular
integration
and
thereby
direct
daily
of
behavior
in
animals
is
largely
obscure.
The
suprachiasmatic
nucleus
(SCN)
the
fulcrum
this
pathway
from
gene
to
cell
circuit
mammals.
We
describe
type-specific,
functionally
distinct
TTFLs
neurons
astrocytes
SCN
show
that,
absence
other
clocks,
cell-autonomous
astrocytic
TTFL
alone
can
drive
molecular
oscillations
circadian
mice.
Astrocytic
by
reinstating
clock
expression
function
via
glutamatergic
signals.
Our
results
demonstrate
that
autonomously
initiate
sustain
complex
mammalian
behavior.
Science,
Journal Year:
2021,
Volume and Issue:
371(6530)
Published: Feb. 11, 2021
Regulating
multiple
body
clocks
Circadian
rhythms
that
affect
tissues
and
organ
systems
are
aligned
with
the
dark-light
cycle
other
external
inputs
such
as
feeding.
But
how
is
time
keeping
modulated
throughout
complex
anatomical
regions?
Koronowski
Sassone-Corsi
reviewed
central
regulators
in
brain
peripheral
organs
can
behave
cooperatively
or
independently
to
modulate
circadian
rhythms.
This
systemic
view
of
rhythm
modulation
important
understand
behavior
disease,
because
dysregulated
associated
metabolic
syndrome
cancer.
Science
,
this
issue
p.
eabd0951
