A visual pathway for skylight polarization processing in Drosophila

eLife, Journal Year: 2021, Volume and Issue: 10

Published: March 23, 2021

Many insects use patterns of polarized light in the sky to orient and navigate. Here, we functionally characterize neural circuitry fruit fly, Drosophila melanogaster , that conveys signals from eye central complex, a brain region essential for fly’s sense direction. Neurons tuned angle polarization ultraviolet are found throughout anterior visual pathway, connecting optic lobes with complex via tubercle bulb, homologous organization ‘sky compass’ pathways described other insects. We detail how consistent, map-like tunings peripheral system is transformed into reduced representation suited flexible processing brain. This study identifies computational motifs transformation, enabling mechanistic comparisons multisensory integration navigation brains

Language: Английский

---

The neural basis for a persistent internal state in Drosophila females

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Nov. 23, 2020

Sustained changes in mood or action require persistent neural activity, but it has been difficult to identify the circuit mechanisms that underlie activity and contribute long-lasting behavior. Here, we show a subset of Doublesex+ pC1 neurons Drosophila female brain, called pC1d/e, can drive minutes-long behavior presence males. Using automated reconstruction volume electron microscopic (EM) image map all inputs outputs both pC1d pC1e. This reveals strong recurrent connectivity between, particular, pC1d/e specific Fruitless+ aIPg. We additionally find activation drives brain areas cells overlapping with network, including neurons. Our work thus links architecture brain.

Language: Английский

---

A projectome of the bumblebee central complex

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Sept. 15, 2021

Insects have evolved diverse and remarkable strategies for navigating in various ecologies all over the world. Regardless of species, insects share presence a group morphologically conserved neuropils known collectively as central complex (CX). The CX is navigational center, involved sensory integration coordinated motor activity. Despite fact that our understanding behavior comes predominantly from ants bees, most what we know about underlying neural circuitry such work fruit flies. Here, aim to close this gap, by providing first comprehensive map major columnar neurons their projection patterns bee. We find numerous components circuit appear be highly between fly bee, but also highlight several key differences which are likely important functional ramifications.

Language: Английский

---

Theory of the Multiregional Neocortex: Large-Scale Neural Dynamics and Distributed Cognition

Annual Review of Neuroscience, Journal Year: 2022, Volume and Issue: 45(1), P. 533 - 560

Published: July 8, 2022

The neocortex is a complex neurobiological system with many interacting regions. How these regions work together to subserve flexible behavior and cognition has become increasingly amenable rigorous research. Here, I review recent experimental theoretical on the modus operandi of multiregional cortex. These studies revealed several general principles for neocortical interareal connectivity, low-dimensional macroscopic gradients biological properties across cortical areas, hierarchy timescales information processing. Theoretical suggests testable predictions regarding differential excitation inhibition along feedforward feedback pathways in hierarchy. Furthermore, modeling distributed working memory simple decision-making given rise novel mathematical concept, dubbed bifurcation space, that potentially explains how different canonical circuit organization but heterogeneities, are able their respective (e.g., sensory coding versus executive control) functions modularly organized brain.

Language: Английский

---

Flexible navigational computations in the Drosophila central complex

Current Opinion in Neurobiology, Journal Year: 2022, Volume and Issue: 73, P. 102514 - 102514

Published: Feb. 19, 2022

Language: Английский

---

Dopamine promotes head direction plasticity during orienting movements

Nature, Journal Year: 2022, Volume and Issue: 612(7939), P. 316 - 322

Published: Nov. 30, 2022

Abstract In neural networks that store information in their connection weights, there is a tradeoff between sensitivity and stability 1,2 . Connections must be plastic to incorporate new information, but if they are too plastic, stored can corrupted. A potential solution allow plasticity only during epochs when task-specific rich, on the basis of ‘when-to-learn’ signal 3 We reasoned dopamine provides when-to-learn allows brain’s spatial maps update available—that is, an animal moving. Here we show neurons innervating Drosophila head direction network specifically active fly turns change its direction. Moreover, activity scales with moment-to-moment fluctuations rotational speed. Pairing release visual cue persistently strengthens cue’s influence cells. Conversely, inhibiting these decreases cue. This mechanism should accelerate learning moments orienting movements providing rich stream allowing rates low at other times protect information. Our results how brain compressed into discrete which high matched intake.

Language: Английский

---

Visual processing in the fly, from photoreceptors to behavior

Genetics, Journal Year: 2023, Volume and Issue: 224(2)

Published: May 2, 2023

Abstract Originally a genetic model organism, the experimental use of Drosophila melanogaster has grown to include quantitative behavioral analyses, sophisticated perturbations neuronal function, and detailed sensory physiology. A highlight these developments can be seen in context vision, where pioneering studies have uncovered fundamental generalizable principles processing. Here we begin with an overview vision-guided behaviors common methods for probing visual circuits. We then outline anatomy physiology brain regions involved processing, beginning at periphery ending descending motor control. Areas focus contrast motion detection optic lobe, circuits feature selectivity, computations support spatial navigation, contextual associative learning. Finally, look future fly neuroscience discuss promising topics further study.

Language: Английский

---

The conserved RNA-binding protein Imp is required for the specification and function of olfactory navigation circuitry in Drosophila

Current Biology, Journal Year: 2024, Volume and Issue: 34(3), P. 473 - 488.e6

Published: Jan. 4, 2024

Complex behaviors depend on the precise developmental specification of neuronal circuits, but relationship between genetic programs for neural development, circuit structure, and behavioral output is often unclear. The central complex (CX) a conserved sensory-motor integration center in insects, which governs many higher-order largely derives from small number type II stem cells (NSCs). Here, we show that Imp, IGF-II mRNA-binding protein expressed NSCs, plays role specifying essential components CX olfactory navigation circuitry. We following: (1) multiple circuitry arise NSCs. (2) Manipulating Imp expression NSCs alters morphology these elements, with most potent effects neurons targeting ventral layers fan-shaped body (FB). (3) regulates Tachykinin-expressing FB input neurons. (4) required establishing proper neuropil structures. (5) Loss abolishes upwind orientation to attractive odor while leaving locomotion odor-evoked regulation movement intact. Taken together, our findings establish temporally gene can regulate behavior by developmentally regulating provides first step toward dissection its roles behavior.

Language: Английский

---

A split-GAL4 driver line resource forDrosophilaneuron types

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 10, 2024

Abstract Techniques that enable precise manipulations of subsets neurons in the fly central nervous system have greatly facilitated our understanding neural basis behavior. Split-GAL4 driver lines allow specific targeting cell types Drosophila melanogaster and other species. We describe here a collection 3060 range adult 1373 characterized third-instar larvae. These tools functional, transcriptomic, proteomic studies based on anatomical targeting. NeuronBridge search relate light microscopy images these split-GAL4 to connectomes reconstructed from electron images. The collections are result screening over 77,000 split hemidriver combinations. Previously published new included, all validated for expression curated optimal type specificity across diverse types. In addition stocks well-characterized lines, we make available 300,000 3D lines.

Language: Английский

---

The fly connectome reveals a path to the effectome

Nature, Journal Year: 2024, Volume and Issue: 634(8032), P. 201 - 209

Published: Oct. 2, 2024

Language: Английский

---