Peripheral vascular remodeling during ischemia DOI Creative Commons

Shigang Lin,

Ruoran Lin, Hongkun Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 1, 2022

About 230 million people worldwide suffer from peripheral arterial disease (PAD), and the prevalence is increasing year by year. Multiple risk factors, including smoking, dyslipidemia, diabetes, hypertension, can contribute to development of PAD. PAD typically characterized intermittent claudication resting pain, there a severe limb ischemia, leading major adverse events, such as amputation. Currently, progress in research field pathogenesis vascular remodeling, atherosclerosis neointima hyperplasia has been made. For example, molecular mechanisms endothelial dysfunction smooth muscle phenotype switching have described. Interestingly, series focused studies on fibroblasts vessel wall demonstrated their impact proliferation even function via cell-cell communications. In this review, we aim focus functional changes cells At same time, summarize current clinical treatment potential therapeutic methods for shine light future perspectives.

Language: Английский

A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing DOI Creative Commons
Jinjian Huang, Rong Yang, Jiao Jiao

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 29, 2023

High glucose-induced vascular endothelial injury is a major pathological factor involved in non-healing diabetic wounds. To interrupt this process, we design an all-peptide printable hydrogel platform based on highly efficient and precise one-step click chemistry of thiolated γ-polyglutamic acid, glycidyl methacrylate-conjugated arginine-glycine-aspartate sequences. Vascular growth 165-overexpressed human umbilical vein cells are printed using platform, hence fabricating living material with high cell viability spatial distribution control. This cell-laden accelerates the wound healing rats unabated 165 release, which promotes angiogenesis alleviates damages mitochondria, thereby reducing tissue hypoxia, downregulating inflammation, facilitating extracellular matrix remodeling. Together, study offers promising strategy for tissue-friendly, high-efficient, accurate 3D delivery self-renewable therapy.

Language: Английский

Citations

68
Endothelial dysfunction in vascular complications of diabetes: a comprehensive review of mechanisms and implications DOI Creative Commons
Dongrong Yang,

Meng‐Yan Wang,

Chenglin Zhang

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: April 5, 2024

Diabetic vascular complications are prevalent and severe among diabetic patients, profoundly affecting both their quality of life long-term prospects. These can be classified into macrovascular microvascular complications. Under the impact risk factors such as elevated blood glucose, pressure, cholesterol lipids, endothelium undergoes endothelial dysfunction, characterized by increased inflammation oxidative stress, decreased NO biosynthesis, endothelial-mesenchymal transition, senescence, even cell death. processes will ultimately lead to diseases, with diseases mainly atherosclerosis (AS) thickening basement membrane. It further indicates a primary contributor morbidity mortality observed in individuals diabetes. In this review, we delve intricate mechanisms that drive dysfunction during diabetes progression its associated Furthermore, outline various pharmacotherapies targeting hope accelerating effective therapeutic drug discovery for early control

Language: Английский

Citations

37
Potential inhibitory effect of Auricularia auricula polysaccharide on advanced glycation end-products (AGEs) DOI
Pin Gong,

Shuya Pei,

Hui Long

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129856 - 129856

Published: Feb. 29, 2024

Language: Английский

Citations

20
The Molecular Pharmacology of Phloretin: Anti-Inflammatory Mechanisms of Action DOI Creative Commons
Solomon Habtemariam

Biomedicines, Journal Year: 2023, Volume and Issue: 11(1), P. 143 - 143

Published: Jan. 6, 2023

The isolation of phlorizin from the bark an apple tree in 1835 led to a flurry research on its inhibitory effect glucose transporters intestine and kidney. Using as prototype drug, antidiabetic agents with more selective activity towards transport at kidney have subsequently been developed. In contrast, hydrolysis product body, phloretin, which is also found plant, has weak properties. Phloretin, however, displays range pharmacological effects including antibacterial, anticancer, cellular organ protective properties both vitro vivo. this communication, molecular basis anti-inflammatory mechanisms that attribute scrutinised. These include inhibiting signalling pathways inflammatory mediators' expression support suppressive immune cells overactivation, obesity-induced inflammation, arthritis, endothelial, myocardial, hepatic, renal lung injury, inflammation gut, skin, nervous system, among others.

Language: Английский

Citations

38
Advanced Glycation End Products and Health: A Systematic Review DOI
Jianming Zhu, Ziming Wang, Chunyan Lv

et al.

Annals of Biomedical Engineering, Journal Year: 2024, Volume and Issue: 52(12), P. 3145 - 3156

Published: May 5, 2024

Language: Английский

Citations

9
Activation of AMPK/miR-181b Axis Alleviates Endothelial Dysfunction and Vascular Inflammation in Diabetic Mice DOI Creative Commons
Chak Kwong Cheng, Wenbin Shang, Jian Liu

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(6), P. 1137 - 1137

Published: June 9, 2022

Hyperglycemia in diabetes mellitus impairs endothelial function and disrupts microRNA (miRNA) profiles vasculature, increasing the risk of diabetes-associated complications, including coronary artery disease, diabetic retinopathy, nephropathy. miR-181b was previously reported to be an anti-inflammatory mediator vasculature against atherosclerosis. The current study aimed investigate whether ameliorates dysfunction, identify potential molecular mechanisms upstream inducer miR-181b. We found that level decreased renal arteries patients advanced glycation end products (AGEs)-treated non-diabetic patients. Transfection mimics improved endothelium-dependent vasodilation aortas high fat diet (HFD)/streptozotocin (STZ)-induced mice, accompanied by suppression superoxide overproduction vascular inflammation markers. AMPK activator-induced activation upregulated human umbilical vein cells (HUVECs). Chronic exercise, potentially through increased blood flow, activated AMPK/miR-181b axis mice. Exposure laminar shear stress expression HUVECs. Overall, our findings highlight a critical role extend benefits chronic exercise counteracting dysfunction.

Language: Английский

Citations

30
A Systematic Review: Quercetin—Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability DOI Open Access
Olimpia Daniela Frenț,

Liana Ștefan,

Claudia Mona Morgovan

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12091 - 12091

Published: Nov. 11, 2024

The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize existing research quercetin's potential health benefits, therapeutic properties, effectiveness in disease prevention treatment. In addition evaluating for drug development with fewer side effects lower toxicity, type attempts collect scientific evidence addressing roles as an antioxidant, anti-inflammatory, antibacterial, anticancer agent. first part, we analyze various flavonoid compounds, focusing their chemical structure, classification, natural sources. We highlight most recent biological activities reported literature. Among these pay special attention quercetin, detailing its physicochemical process biosynthesis plants. also present sources emphasize such antioxidant anti-inflammatory effects. Additionally, discuss methods enhance bioavailability, analyzing latest effective delivery systems based quercetin.

Language: Английский

Citations

8
AMPK activation eliminates senescent cells in diabetic wound by inducing NCOA4 mediated ferritinophagy DOI Creative Commons

Mengqian Liu,

Xuerong Wei,

Zijun Zheng

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: May 17, 2024

Abstract Background Diabetic wounds are one of the long-term complications diabetes, with a disordered microenvironment, diabetic can easily develop into chronic non-healing wounds, which impose significant burden on healthcare. In condition, senescent cells accumulate in wound area and suppress healing process. AMPK, as molecule related to metabolism, has close relationship aging diabetes. The purpose this study was investigate effects AMPK activation explore underlying mechanisms. Methods activator A769662 topically applied models mice. Alterations site were observed analyzed by immunohistochemistry. markers autophagy ferritinophagy western blotting immunofluorescence staining. role also blotting. Results Our results show that improved reduced accumulation cells. Intriguingly, we found activation-induced ferroptosis is autophagy-dependent. We detected level ferritin had deceased NCOA4 markedly increased after treatment. further investigated NCOA4-mediated involved triggered activation. Most importantly, reverse ferroptosis-insensitive fibroblast mice promote healing. Conclusions These suggest activating reversing may serve regulatory factor area, therefore become promising therapeutic method for wounds.

Language: Английский

Citations

7
Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK/FoxO3/SIRT3 axis DOI

Tinglv Fu,

Guorui Li, Donghang Li

et al.

Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: 45(5), P. 1002 - 1018

Published: Jan. 15, 2024

Language: Английский

Citations

6
Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1 DOI Creative Commons
Jinfeng Peng, Jiajia Zhao, Qingming Tang

et al.

International Journal of Oral Science, Journal Year: 2022, Volume and Issue: 14(1)

Published: Nov. 14, 2022

Abstract Bone regeneration remains a great clinical challenge. Low intensity near-infrared (NIR) light showed strong potential to promote tissue regeneration, offering promising strategy for bone defect regeneration. However, the effect and underlying mechanism of NIR on remain unclear. We demonstrated that in rat skull model was significantly accelerated with low-intensity stimulation. In vitro studies stimulation could osteoblast differentiation mesenchymal stem cells (BMSCs) MC3T3-E1 cells, which associated increased ubiquitination core circadian clock protein Cryptochrome 1 (CRY1) nucleus. found reduction CRY1 induced by activated morphogenetic (BMP) signaling pathways, promoting SMAD1/5/9 phosphorylation increasing expression levels Runx2 Osterix . treatment may act through sodium voltage-gated channel Scn4a , be responder accelerate Together, these findings suggest situ CRY1-dependent manner, providing novel, efficient non-invasive defects.

Language: Английский

Citations

24