N-Acetylcysteine Alleviated the Deltamethrin-Induced Oxidative Cascade and Apoptosis in Liver and Kidney Tissues DOI Open Access

Ali M. Allam,

Ahmed Abdeen, Hari Prasad Devkota

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(2), P. 638 - 638

Published: Jan. 6, 2022

Deltamethrin (DLM) is a synthetic pyrethroid with anti-acaricide and insecticidal properties. It commonly used in agriculture veterinary medicine. Humans animals are exposed to DLM through the ingestion of polluted food water, resulting severe health issues. N-acetylcysteine (NAC) prodrug L-cysteine, precursor glutathione. can restore oxidant-antioxidant balance. Therefore, this research aimed examine whether NAC may protect broiler chickens against oxidative stress, at level biochemical molecular alterations caused by intoxication. The indicators liver kidney injury serum DLM-intoxicated NAC-treated groups were examined. Furthermore, lipid peroxidation, antioxidant markers, superoxide dismutase activity, apoptotic gene expressions (caspase-3 Bcl-2) investigated. All parameters significantly altered group, suggesting that could induce damage apoptosis hepato-renal tissue. majority changes studied reversed when therapy was used. In conclusion, virtue its antiapoptotic properties, enabled provision significant protection effects DLM-induced injury.

Language: Английский

Harmful Effects of Inorganic Mercury Exposure on Kidney Cells: Mitochondrial Dynamics Disorder and Excessive Oxidative Stress DOI
Biqi Han,

Zhanjun Lv,

Xue‐Min Han

et al.

Biological Trace Element Research, Journal Year: 2021, Volume and Issue: 200(4), P. 1591 - 1597

Published: May 31, 2021

Language: Английский

Citations

74
The heart as a target for deltamethrin toxicity: Inhibition of Nrf2/HO-1 pathway induces oxidative stress and results in inflammation and apoptosis DOI
Xue Yang,

Yi Fang,

Jianbo Hou

et al.

Chemosphere, Journal Year: 2022, Volume and Issue: 300, P. 134479 - 134479

Published: March 31, 2022

Language: Английский

Citations

63
Pesticide impacts on avian species with special reference to farmland birds: a review DOI
Jérôme Moreau, Juliette Rabdeau, Isabelle Badenhausser

et al.

Environmental Monitoring and Assessment, Journal Year: 2022, Volume and Issue: 194(11)

Published: Sept. 15, 2022

Language: Английский

Citations

56
Effects of thiacloprid exposure on microbiota–gut–liver axis: Multiomics mechanistic analysis in Japanese quails DOI
Biqi Han, Jiayi Li, Siyu Li

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 442, P. 130082 - 130082

Published: Sept. 30, 2022

Language: Английский

Citations

39
Chronic arsenic exposure induces ferroptosis via enhancing ferritinophagy in chicken livers DOI
Lu Yu,

Zhanjun Lv,

Siyu Li

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 890, P. 164172 - 164172

Published: May 16, 2023

Language: Английский

Citations

32
Inflammation response after the cessation of chronic arsenic exposure and post-treatment of natural astaxanthin in liver: potential role of cytokine-mediated cell–cell interactions DOI
Zhigang Zhang,

Changming Guo,

Huijie Jiang

et al.

Food & Function, Journal Year: 2020, Volume and Issue: 11(10), P. 9252 - 9262

Published: Jan. 1, 2020

Schematic diagram of the mechanism post treatment with natural astaxanthin attenuating arsenic-induced inflammatory response in rat liver.

Language: Английский

Citations

68
Pulmonary inflammatory and fibrogenic response induced by graphitized multi-walled carbon nanotube involved in cGAS-STING signaling pathway DOI
Bing Han, Xiaoqiao Wang, Pengfei Wu

et al.

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 417, P. 125984 - 125984

Published: May 4, 2021

Language: Английский

Citations

55
Deltamethrin induces apoptosis in cerebrum neurons of quail via promoting endoplasmic reticulum stress and mitochondrial dysfunction DOI
Siyu Li, Pengfei Wu, Bing Han

et al.

Environmental Toxicology, Journal Year: 2022, Volume and Issue: 37(8), P. 2033 - 2043

Published: April 21, 2022

Deltamethrin (DLM) is a widely used and highly effective insecticide. DLM exposure harmful to animal human. Quail, as bird model, has been in the field of toxicology. However, there little information available literature about quail cerebrum damage caused by DLM. Here, we investigated effect on neurons. Four groups healthy quails were assigned (10 each group), respectively given 0, 15, 30, 45 mg/kg gavage for 12 weeks. Through measurements cerebrum, it was found that induced obvious histological changes, oxidative stress, neurons apoptosis. To further explore possible molecular mechanisms, performed real-time quantitative PCR detect expression endoplasmic reticulum (ER) stress-related mRNA such glucose regulated protein 78 kD, activating transcription factor 6, inositol requiring enzyme, kinase RNA (PKR)-like ER kinase. In addition, detected ATP content evaluate functional status mitochondria. The study showed significantly increased decreased tissues. These results suggest chronic induces apoptosis via promoting stress mitochondrial dysfunction. Furthermore, our provide novel explanation DLM-induced avian

Language: Английский

Citations

38
Activation of the GPX4/TLR4 Signaling Pathway Participates in the Alleviation of Selenium Yeast on Deltamethrin-Provoked Cerebrum Injury in Quails DOI
Jiayi Li,

Zhongxian Yu,

Bing Han

et al.

Molecular Neurobiology, Journal Year: 2022, Volume and Issue: 59(5), P. 2946 - 2961

Published: March 5, 2022

Language: Английский

Citations

37
Upregulation of Nrf2 signaling and suppression of ferroptosis and NF-κB pathway by leonurine attenuate iron overload-induced hepatotoxicity DOI
Samir A. Salama, Mohamed S. Abdel‐Bakky, Alaa A. Mohamed

et al.

Chemico-Biological Interactions, Journal Year: 2022, Volume and Issue: 356, P. 109875 - 109875

Published: March 3, 2022

Language: Английский

Citations

32