Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish

Journal of Developmental Biology, Journal Year: 2022, Volume and Issue: 10(4), P. 49 - 49

Published: Nov. 21, 2022

Organophosphate (OP) insecticides are used to eliminate agricultural threats posed by insects, through inhibition of the neurotransmitter acetylcholinesterase (AChE). These potent neurotoxins extremely efficacious in insect elimination, and as such, preferred worldwide. Despite their efficacy, however, estimates indicate that only 0.1% organophosphates reach desired target. Moreover, multiple studies have shown OP exposure both humans animals can lead aberrations embryonic development, defects childhood neurocognition, substantial contribution neurodegenerative diseases such Alzheimer’s Motor Neurone Disease. Here, we review current state knowledge pertaining organophosphate on development and/or subsequent neurological consequences behaviour, paying particular attention data gleaned using an excellent animal model, zebrafish (Danio rerio).

Language: Английский

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Chitosan oligosaccharide alleviates and removes the toxicological effects of organophosphorus pesticide chlorpyrifos residues

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 446, P. 130669 - 130669

Published: Dec. 24, 2022

Language: Английский

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Comparative toxicogenomics of benzotriazole ultraviolet stabilizers at environmental concentrations in Asian clam (Corbicula fluminea): Insight into molecular networks and behavior

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 447, P. 130811 - 130811

Published: Jan. 16, 2023

Language: Английский

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Molecular and Biochemical Evidence of the Toxic Effects of Terbuthylazine and Malathion in Zebrafish

Animals, Journal Year: 2023, Volume and Issue: 13(6), P. 1029 - 1029

Published: March 11, 2023

Our research sought to determine the molecular and biochemical effects of environmentally relevant exposure commonly used chloro-s-triazine herbicide terbuthylazine organophosphate insecticide malathion on zebrafish. To this aim, mature zebrafish were exposed 2 30 µg L-1 5 50 alone in combination for 14 days. Aside from accumulation TBARS protein carbonyls, a decrease antioxidants succinate dehydrogenase activity, an increase oxidized glutathione, enhanced apoptosis via Caspase-3 BAX overexpression observed. Furthermore, induced mitochondrial swelling (up 210% after single up 470% co-exposure) lactate leakage 268% 570% concentration-dependent manner. Significant upregulation ubiquitin expression increased cathepsin D activity characteristics that appeared only upon exposure, whereas induction IgM was identified as specific characteristic toxicity. Meanwhile, no alterations hypothalamic-pituitary-thyroid axis Co-exposure adverse individual pesticides This study should improve understanding mechanisms pesticide toxicity lead fish impairment biodiversity decline.

Language: Английский

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Effects of Glyphosate or Glyphosate-Based Herbicide during the Zebrafish Life Cycle: A Review Addressing the Mechanisms of Toxicity

Water, Journal Year: 2023, Volume and Issue: 15(12), P. 2276 - 2276

Published: June 17, 2023

Herbicides with glyphosate (GLY) as an active ingredient (a.i.) are increasingly used, and GLY is currently the most used herbicide in world. Consequently, its residues have often been found aquatic ecosystems. Investigating how this substance affects species a priority ecotoxicology research, especially fish, they can absorb concentrate toxins. In sense, critical review was performed, synthesizing data from peer-reviewed bibliography, reporting on toxicity of exposure to pure glyphosate-based herbicides (GBHs), using zebrafish animal model. The concentrations that induced toxic effects highly variable, some exceeding limits determined by regulatory agencies. Globally, relevant reported zebrafish, namely, teratogenic incompatible life, which translates directly into increase mortality. Neurotoxicity, genotoxicity, changes energy metabolism oxidative stress, immune hormonal system dysfunction impact fish reproduction were also described. conclusion, both GBHs may induce damage compromising their survival, reproduction, maintenance. These results be valid applied other

Language: Английский

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Glyphosate-based herbicide (GBH) causes damage in embryo-larval stages of zebrafish (Danio rerio)

Neurotoxicology and Teratology, Journal Year: 2022, Volume and Issue: 95, P. 107147 - 107147

Published: Dec. 7, 2022

Language: Английский

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Minocycline attenuates the bilirubin-induced developmental neurotoxicity through the regulation of innate immunity and oxidative stress in zebrafish embryos

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 484, P. 116859 - 116859

Published: Feb. 9, 2024

Language: Английский

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Dynamic changes in weed abundance and biodiversity following different green manure establishment

Journal of Integrative Agriculture, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Weeds have a negative impact on agricultural production by competing with cultivated crops for resources and fostering conditions conducive to disease insect pest dissemination. Hence, optimal weed management is of paramount importance sustainable agricultural. In this study, the ability four distinct green manure species suppress weeds was determined in field experiment conducted Chongqing, Southwest China. After cultivating species, density diversity were monitored over following year. The findings highlight notable trend suppressive manures, increased suppression observed from November March, an level March May, gradual decline thereafter. Poaceae (Lolium perenne L.) demonstrated highest efficacy suppressing weeds. meta-analysis underscore exceptional effects poaceous manures as well prove sustained planting three or more consecutive years yielded superior outcomes. Green had most prominent inhibitory effect poaceae weeds, followed Polygonaceae Caryophyllaceae. also investigated community composition, they proportion perennial within these communities. This study offers valuable insights that can guide policymakers, experts, farmers devising effective strategies. By highlighting potential benefits unraveling their nuanced impact, contributes arsenal practices.

Language: Английский

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The use of amino acids and their derivates to mitigate against pesticide-induced toxicity

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 276, P. 116340 - 116340

Published: April 17, 2024

Exposure to pesticides induces oxidative stress and deleterious effects on various tissues in non-target organisms. Numerous models investigating pesticide exposure have demonstrated metabolic disturbances such as imbalances amino acid levels within the organism. One potentially effective strategy mitigate toxicity involves dietary intervention by supplementing exogenous acids their derivates augment body's antioxidant capacity pesticide-induced harm, whose mechanism including bolstering glutathione synthesis, regulating arginine-NO metabolism, mitochondria-related stress, open of ion channels, well enhancing intestinal microecology. Enhancing synthesis through supplementation substrates N-acetylcysteine glycine is regarded a potent achieve this. Selection appropriate or for supplementation, determining an dosage, are utmost importance mitigation harm. More experimentation required that large population samples validate efficacy strategies, determine long-term low-dose exposure. This review provides insights guide future research aimed at preventing alleviating derivates.

Language: Английский

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Illicit Drugs in Surface Waters: How to Get Fish off the Addictive Hook

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 537 - 537

Published: April 22, 2024

The United Nations World Drug Report published in 2022 alarmed that the global market of illicit drugs is steadily expanding space and scale. Substances abuse are usually perceived light threats to human health public security, while environmental aspects their use subsequent emissions remain less explored. However, as with other activities, drug production, trade, consumption may leave mark. Therefore, this paper aims review occurrence surface waters bioaccumulation toxicity fish. Illicit different groups, i.e., psychostimulants (methamphetamines/amphetamines, cocaine, its metabolite benzoylecgonine) depressants (opioids: morphine, heroin, methadone, fentanyl), can reach aquatic environment through wastewater discharge they often not entirely removed during treatment processes, resulting circulation nanomolar concentrations, potentially affecting biota, including Exposure such xenobiotics induce oxidative stress dysfunction mitochondrial lysosomal function, distort locomotion activity by regulating dopaminergic glutamatergic systems, increase predation risk, instigate neurological disorders, disbalance neurotransmission, produce histopathological alterations brain liver tissues, similar those described mammals. Hence, drugs-related multidimensional harm fish should be thoroughly investigated line protection policies before it too late. At same time, selected species (e.g., Danio rerio, zebrafish) employed models study toxic binge-like effects psychoactive, compounds.

Language: Английский

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