Airborne micro- and nanoplastics: emerging causes of respiratory diseases DOI Creative Commons
Zixuan Gou, Haonan Wu, Shanyu Li

et al.

Particle and Fibre Toxicology, Journal Year: 2024, Volume and Issue: 21(1)

Published: Dec. 4, 2024

Airborne micro- and nanoplastics (AMNPs) are ubiquitously present in human living environments pose significant threats to respiratory health. Currently, much research has been conducted on the relationship between (MNPs) cardiovascular gastrointestinal diseases, yet there is a clear lack of understanding regarding link AMNPs diseases. Therefore, it imperative explore two. Recent extensive studies by numerous scholars characteristics their with diseases have robustly demonstrated that from various sources significantly influence onset progression conditions. Thus, investigating intrinsic mechanisms involved finding necessary preventive therapeutic measures crucial. In this review, we primarily describe fundamental AMNPs, impact system, toxic facilitate disease development. It hoped article will provide new insights for further contribute advancement

Language: Английский

Exposure to different surface-modified polystyrene nanoparticles caused anxiety, depression, and social deficit in mice via damaging mitochondria in neurons DOI
Yuhan Ma, Dihui Xu,

Zicheng Wan

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 919, P. 170739 - 170739

Published: Feb. 9, 2024

Language: Английский

Citations

20
Exposure to polystyrene nanoplastics induces abnormal activation of innate immunity via the cGAS-STING pathway DOI Creative Commons
Lihui Xuan, Yin Wang,

Can Qu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 275, P. 116255 - 116255

Published: March 28, 2024

Endogenous immune defenses provide an intrinsic barrier against external entity invasion. Microplastics in the environment, especially those at nanoscale (nanoplastics or NPs), may pose latent health risks through direct exposure. While links between nanoplastics and inflammatory processes have been established, detailed insights into how they perturb innate mechanisms remain uncharted. Employing murine macrophage (RAW264.7) cellular models subjected to polystyrene (PS-NPs), our investigative approach encompassed array of techniques: Cell Counting Kit-8 assays, flow cytometric analysis, acridine orange/ethidium bromide (AO/EB) fluorescence staining, cell transfection, cycle scrutiny, genetic manipulation, messenger RNA expression profiling via quantitative real-time PCR, protein evaluation western blotting. The results showed that PS-NPs caused RAW264.7 apoptosis, leading arrest, activated cGAS-STING pathway. This resulted NF-κB signaling activation increased pro-inflammatory mediator expression. Importantly, PS-NPs-induced its downstream cascade were markedly diminished after silencing STING gene. Our findings highlight critical role pathway immunotoxic effects induced by PS-NPs. We outline a new mechanism whereby trigger dysregulated responses cGAS/STING

Language: Английский

Citations

10
Inhaled polystyrene microplastics impaired lung function through pulmonary flora/TLR4-mediated iron homeostasis imbalance DOI

Huiwen Kang,

Danyang Huang, Wei Zhang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 946, P. 174300 - 174300

Published: June 25, 2024

Language: Английский

Citations

8
Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage DOI Creative Commons
Shan Tian, Ruixue Li, Jiao Li

et al.

Environment International, Journal Year: 2025, Volume and Issue: 195, P. 109258 - 109258

Published: Jan. 1, 2025

Nanoplastics (NPs) have attracted widespread attention owing to their presence in the body. Recent studies highlighted detrimental effects of NPs on digestive tract. However, no reported an association between exposure and colitis-associated cancer (CAC). An azoxymethane/dextran sodium sulfate-induced CAC model was used, polystyrene nanoparticles (PS-NPs) were selected for long-term exposure. Non-targeted metabolomics 16S rRNA sequencing used detect changes colonic metabolites gut microbes following PS-NPs A lipopolysaccharide (LPS)-treated cell (Caco-2) exposed investigate underlying molecular mechanism. Compared normal control group, mice group exhibited more tumor nodes reactive oxygen species (ROS), higher expression pan-CK Ki-67, severe DNA damage. revealed that altered abundance Allobaculum Lactobacillus, whereas metabolic analysis showed most significant enriched mostly fatty acid metabolism. Experiments LPS intervened Caco-2 cells led lipid peroxidation, oxidative stress, damage Caco-2. Exposure activated phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target rapamycin (mTOR) signaling pathway both AOM/DSS mouse cellular model. Key proteins involved metabolism downregulated PS-NPs. The significantly inhibited by activation fenofibrate. disturbed induced via PI3K/AKT/mTOR promote progression. Inhibition is a therapeutic controlling PS-NP-induced CAC. Our study provides important reference prevention treatment from perspective environment enhances awareness necessity plastic control.

Language: Английский

Citations

1
Systematic review of pulmonary toxicity induced by microplastics and nanoplastics: Insights from in vivo and in vitro studies DOI

Reza Nozari asl,

N. Jaafarzadeh, Faezeh Jahedi

et al.

Annales de Toxicologie Analytique, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Melatonin protects against cadmium-induced endoplasmic reticulum stress and ferroptosis through activating Nrf2/HO-1 signaling pathway in mice lung DOI

Ziyang Huang,

Rui‐Jia Xu,

Zhongjun Wan

et al.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115324 - 115324

Published: Feb. 1, 2025

Language: Английский

Citations

1
N-Acetylcysteine Mitigates Ketamine Neurotoxicity in Young Rats by Modulating ROS-Mediated Pyroptosis and Ferroptosis DOI
Hui Bai, Hui Chen,

Shan Du

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Language: Английский

Citations

1
Baicalin protects against hepatocyte injury caused by aflatoxin B1 via the TP53-related ferroptosis Pathway DOI Creative Commons

H. Zhang,

Jian-Zhu Luo,

Chenlu Lan

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 281, P. 116661 - 116661

Published: July 1, 2024

Baicalin has antioxidative, antiviral, and anti-inflammatory properties. However, its ability to alleviate oxidative stress (OS) DNA damage in liver cells exposed aflatoxin B1 (AFB1), a highly hepatotoxic compound, remains uncertain. In this study, the protective effects of baicalin on AFB1-induced hepatocyte injury mechanisms underlying those were investigated. Stable cell lines expressing CYP3A4 established using lentiviral vectors assess levels by conducting assays determine content reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD). Additionally, was evaluated 8-hydroxy-2-deoxyguanosine (8-OHdG) comet assays. Transcriptome sequencing, molecular docking, vitro experiments conducted injury. vivo, rat model induced AFB1 used evaluate baicalin. vitro, significantly attenuated caused due OS, as determined decrease ROS, MDA, SOD levels. also considerably decreased hepatocytes. This effect found be closely associated with TP53-mediated ferroptosis pathway. To elaborate, physically interacts P53, leading suppression expression GPX4 SLC7A11, which turn inhibits ferroptosis. vivo findings showed that AFB1-treated tissues, γ-H2AX an increase SLC7A11 Overexpression TP53 weakened can OS via theoretical foundation for use protecting from toxic AFB1.

Language: Английский

Citations

6
Selenium deficiency exacerbated Bisphenol A-induced intestinal toxicity in chickens: Apoptosis and cell cycle arrest mediated by ROS/P53 DOI

Dongliu Luo,

Xinyu Tang, Yixuan Wang

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 913, P. 169730 - 169730

Published: Dec. 30, 2023

Language: Английский

Citations

15
A systematic review of microplastics emissions in kitchens: Understanding the links with diseases in daily life DOI Creative Commons

Yinai Liu,

Yu Cao, Huiqi Li

et al.

Environment International, Journal Year: 2024, Volume and Issue: 188, P. 108740 - 108740

Published: May 11, 2024

The intensification of microplastics (MPs) pollution has emerged as a formidable environmental challenge, with profound global implications. pervasive presence MPs across multitude mediums, such the atmosphere, soil, and oceans, extends to commonplace items, culminating in widespread human ingestion accumulation via channels like food, water, air. In domestic realm, kitchens have become significant epicenters for pollution. A plethora kitchen utensils, encompassing coated non-stick pans, plastic cutting boards, disposable are known release substantial quantities particles everyday use, which can then be ingested alongside food. This paper conducts thorough examination contemporary research addressing from utensils during usage focuses on health risks associated ingestion, well myriad factors influencing utensils. Leveraging insights derived this analysis, proposes series strategic recommendations measures targeted at mitigating production settings. These initiatives designed not solely diminish but also enhance public awareness regarding pressing concern. By adopting more informed practices kitchens, we significantly contribute reduction burden pollution, thus safeguarding both ecological system.

Language: Английский

Citations

5