Advances in the Sensing and Treatment of Wound Biofilms

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(13)

Published: Nov. 22, 2021

Wound biofilms represent a particularly challenging problem in modern medicine. They are increasingly antibiotic resistant and can prevent the healing of chronic wounds. However, current treatment diagnostic options hampered by complexity biofilm environment. In this review, we present new chemical avenues sensors materials to treat wound biofilms, offering promise for better detection, specificity, biocompatibility. We briefly discuss existing methods detection focus on novel, sensor-based approaches that show early, accurate formation sites be translated point-of-care settings. then technologies inspired efficient eradication. ultrasound-induced microbubbles nanomaterials both penetrate simultaneously carry active antimicrobials benefits those comparison conventional methods.

Language: Английский

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Size-dependent photothermal antibacterial activity of Ti C T MXene nanosheets against methicillin-resistant Staphylococcus aureus

Journal of Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 617, P. 533 - 541

Published: March 9, 2022

Language: Английский

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Recent Nanotechnologies to Overcome the Bacterial Biofilm Matrix Barriers

Small, Journal Year: 2022, Volume and Issue: 19(6)

Published: Dec. 5, 2022

Abstract Bacterial biofilm‐related infectious diseases severely influence human health. Under typical situations, pathogens can colonize inert or biological surfaces and form biofilms. Biofilms are functional aggregates that coat bacteria with extracellular polymeric substances (EPS). The main reason for the failure of biofilm infection treatment is low permeability enrichment therapeutic agents within biofilm, which results from particular features matrix barriers such as negatively charged components highly viscous compact EPS structures. Hence, developing novel strategies enhanced penetrability crucial. Herein, current progress nanotechnology methods to improve agents’ against matrix, regulating material morphology surface properties, utilizing physical penetration nano/micromotors microneedle patches, equipping nanoparticles degradation enzymes signal molecules, first summarized. Finally, challenges, perspectives, future implementations engineered delivery systems manage infections presented in detail.

Language: Английский

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Plant Growth-Promoting Bacteria (PGPB) with Biofilm-Forming Ability: A Multifaceted Agent for Sustainable Agriculture

Diversity, Journal Year: 2023, Volume and Issue: 15(1), P. 112 - 112

Published: Jan. 13, 2023

Plant growth-promoting bacteria (PGPB) enhance plant growth, as well protect plants from several biotic and abiotic stresses through a variety of mechanisms. Therefore, the exploitation PGPB in agriculture is feasible it offers sustainable eco-friendly approaches to maintaining soil health while increasing crop productivity. The vital key application its effectiveness colonizing roots phyllosphere, developing protective umbrella formation microcolonies biofilms. Biofilms offer benefits PGPB, such enhancing resistance adverse environmental conditions, protecting against pathogens, improving acquisition nutrients released environment, facilitating beneficial bacteria–plant interactions. bacterial biofilms can successfully compete with other microorganisms found on surfaces. In addition, plant-associated are capable colonization sites, cycling nutrients, pathogen defenses, tolerance stresses, thereby agricultural productivity yields. This review highlights role surfaces strategies used by biofilm-forming PGPB. Moreover, factors influencing biofilm at root shoot interfaces critically discussed. will pave formulations addressing challenges related their efficacy competence for sustainability.

Language: Английский

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Nanoplastic occurrence, transformation and toxicity: a review

Environmental Chemistry Letters, Journal Year: 2022, Volume and Issue: 21(1), P. 363 - 381

Published: Aug. 28, 2022

Language: Английский

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Detection and various environmental factors of antibiotic resistance gene horizontal transfer

Environmental Research, Journal Year: 2022, Volume and Issue: 212, P. 113267 - 113267

Published: April 9, 2022

Language: Английский

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Titanium Dental Implants: An Overview of Applied Nanobiotechnology to Improve Biocompatibility and Prevent Infections

Materials, Journal Year: 2022, Volume and Issue: 15(9), P. 3150 - 3150

Published: April 27, 2022

This review addresses the different aspects of use titanium and its alloys in production dental implants, most common causes implant failures development improved surfaces capable stimulating osseointegration guaranteeing long-term success implants. Titanium is main material for implants; despite this, surface modifications are studied aiming to improve process. Nanoscale bioactivation with biological molecules can promote faster healing when compared smooth surfaces. Recent studies have also pointed out that gradual changes implant, based on microenvironment insertion, factors may integration soft bone tissues, preventing infections failures. In this context, understanding nanobiotechnological implants process arouses interest new strategies, which a highly relevant factor materials.

Language: Английский

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Advances in Nanotechnology for Biofilm Inhibition

ACS Omega, Journal Year: 2023, Volume and Issue: 8(24), P. 21391 - 21409

Published: June 7, 2023

Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible range multidrug-resistant pathogens. These pathogens show reduced susceptibility intracellular survival. However, current methods for treating biofilms, such smart materials targeted drug delivery systems, not been found effective in preventing biofilm formation. To address this challenge, nanotechnology provided innovative solutions formation by clinically relevant Recent advances nanotechnological strategies, including metallic nanoparticles, functionalized dendrimers, polymeric cyclodextrin-based delivery, solid lipid polymer conjugates, liposomes, may provide valuable technological against infectious diseases. Therefore, it is imperative conduct comprehensive review summarize the recent advancements limitations advanced nanotechnologies. present Review encompasses summary agents, mechanisms that lead formation, impact on human health. In nutshell, offers survey managing infections. A detailed presentation how these strategies improve control prevent key objective mechanisms, applications, prospects nanotechnologies better understanding

Language: Английский

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Polysaccharides’ Structures and Functions in Biofilm Architecture of Antimicrobial-Resistant (AMR) Pathogens

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 4030 - 4030

Published: Feb. 17, 2023

Bacteria and fungi have developed resistance to the existing therapies such as antibiotics antifungal drugs, multiple mechanisms are mediating this resistance. Among these, formation of an extracellular matrix embedding different bacterial cells, called biofilm, is effective strategy through which fungal cells establishing a relationship in unique environment. The biofilm provides them possibility transfer genes conferring resistance, prevent from desiccation impede penetration or drugs. Biofilms formed several constituents including DNA, proteins polysaccharides. Depending on bacteria, polysaccharides form microorganisms, some involved first stage cells’ attachment surfaces each other, responsible for giving structure stability. In review, we describe role biofilms, revise analytical methods characterize quantitatively qualitatively finally provide overview potential new antimicrobial able inhibit by targeting exopolysaccharides.

Language: Английский

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Nanotechnology in combating biofilm: A smart and promising therapeutic strategy

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: March 3, 2023

Since the birth of civilization, people have recognized that infectious microbes cause serious and often fatal diseases in humans. One most dangerous characteristics microorganisms is their propensity to form biofilms. It linked development long-lasting infections more severe illness. An obstacle eliminating such intricate structures resistance drugs now utilized clinical practice (biofilms). Finding new compounds with anti-biofilm effect is, thus, essential. Infections caused by bacterial biofilms are something nanotechnology has lately shown promise treating. More studies being conducted determine whether nanoparticles (NPs) useful fight against infections. While there been a small number trials, several vitro outcomes examining effects antimicrobial NPs. Nanotechnology provides secure delivery platforms for targeted treatments combat wide range microbial The increase pharmaceuticals’ bioactive potential one many ways which applied drug delivery. current research details utilization medication strategy managing biofilms, including metal oxide nanoparticles, liposomes, micro-, nanoemulsions, solid lipid polymeric nanoparticles. Our understanding how these nanosystems aid expanded through use.

Language: Английский

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