Islet
transplantation
has
now
become
a
promising
treatment
for
insulin-deficient
diabetes
mellitus.
Compared
to
traditional
treatments,
cell
therapy
can
restore
endogenous
insulin
supplementation,
but
its
large-scale
clinical
application
is
impeded
by
donor
shortages,
immune
rejection,
and
unsuitable
sites.
To
overcome
these
challenges,
an
increasing
number
of
studies
have
attempted
transplant
hydrogel-encapsulated
islet
cells
treat
diabetes.
This
review
mainly
focuses
on
the
strategy
pancreatic
diabetic
therapy,
including
different
sources
encapsulated
in
hydrogels,
encapsulation
methods,
hydrogel
types,
series
accessorial
manners
improve
outcomes.
In
addition,
formation
challenges
as
well
prospects
are
also
presented.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(26)
Published: March 20, 2023
The
Hoffmeister
effect
of
inorganic
salts
is
verified
as
a
promising
way
to
toughen
hydrogels,
however,
the
high
concentration
may
be
accompanied
by
poor
biocompatibility.
In
this
work,
it
found
that
polyelectrolytes
can
obviously
elevate
mechanical
performances
hydrogels
through
effect.
introduction
anionic
poly(sodium
acrylate)
into
poly(vinyl
alcohol)
(PVA)
hydrogel
induces
aggregation
and
crystallization
PVA
boost
properties
resulting
double-network
hydrogel:
elevation
73,
64,
28,
135,
19
times
in
tensile
strength,
compressive
Young's
modulus,
toughness,
fracture
energy
compared
with
poly(acrylic
acid),
respectively.
It
noteworthy
flexibly
tuned
variation
polyelectrolyte
concentration,
ionization
degree,
relative
hydrophobicity
ionic
component,
type
wide
range.
This
strategy
work
for
other
Hoffmeister-effect-sensitive
polymers
polyelectrolytes.
Also,
urea
bonds
further
improve
antiswelling
capability
hydrogels.
As
biomedical
patch,
advanced
efficiently
inhibit
hernia
formation
promote
regeneration
soft
tissues
an
abdominal
wall
defect
model.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: July 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(17), P. 6191 - 6220
Published: Jan. 1, 2023
This
review
highlights
the
recent
progress
in
piezoelectric
gels
(also
known
as
PiezoGels)
comprised
of
polymers,
ceramic
oxides
and
supramolecular
materials
used
for
energy
harvesting,
sensing
wound
dressing.
Small,
Journal Year:
2023,
Volume and Issue:
20(9)
Published: Oct. 10, 2023
Abstract
Conductive
microfibers
play
a
significant
role
in
the
flexibility,
stretchability,
and
conductivity
of
electronic
skin
(e‐skin).
Currently,
fabrication
conductive
suffers
from
either
time‐consuming
complex
operations
or
is
limited
environments.
Thus,
it
presents
one‐step
method
to
prepare
hydrogel
based
on
microfluidics
for
construction
ultrastretchable
e‐skin.
The
are
achieved
with
MXene
cores
shells,
which
solidified
covalent
cross‐linking
between
sodium
alginate
calcium
chloride,
mechanically
enhanced
by
complexation
reaction
poly(vinyl
alcohol)
hydroxide.
microfiber
conductivities
tailorable
adjusting
flow
rate
concentration
core
shell
fluids,
essential
more
practical
applications
scenarios.
More
importantly,
patterned
e‐skin
can
be
constructed
combining
3D
printing
technology.
Because
great
advantages
mechanical
electrical
performance
microfibers,
shows
impressive
stretching
sensitivity,
also
demonstrate
attractive
application
values
motion
monitoring
gesture
recognition.
These
characteristics
indicate
that
has
potential
health
monitoring,
wearable
devices,
smart
medicine.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(3), P. 1470 - 1470
Published: Feb. 3, 2023
Supramolecular
polymers
have
attracted
considerable
interest
due
to
their
intriguing
features
and
functions.
The
dynamic
reversibility
of
noncovalent
interactions
endows
supramolecular
with
tunable
physicochemical
properties,
self-healing,
externally
stimulated
responses.
Among
them,
pillararene-based
show
great
potential
for
biomedical
applications
fascinating
host–guest
easy
modification.
Herein,
we
summarize
the
state
art
cancer
therapy
illustrate
its
developmental
trend
future
perspective.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(18), P. 10435 - 10508
Published: Sept. 16, 2024
The
mechanical
properties
of
polymer
gels
devote
to
emerging
devices
and
machines
in
fields
such
as
biomedical
engineering,
flexible
bioelectronics,
biomimetic
actuators,
energy
harvesters.
Coupling
network
architectures
interactions
has
been
explored
regulate
supportive
characteristics
gels;
however,
systematic
reviews
correlating
mechanics
interaction
forces
at
the
molecular
structural
levels
remain
absent
field.
This
review
highlights
engineering
gel
a
comprehensive
mechanistic
understanding
regulation.
Molecular
alters
architecture
manipulates
functional
groups/moieties
level,
introducing
various
permanent
or
reversible
dynamic
bonds
dissipative
energy.
usually
uses
monomers,
cross-linkers,
chains,
other
additives.
Structural
utilizes
casting
methods,
solvent
phase
regulation,
mechanochemistry,
macromolecule
chemical
reactions,
biomanufacturing
technology
construct
tailor
topological
structures,
heterogeneous
modulus
compositions.
We
envision
that
perfect
combination
may
provide
fresh
view
extend
exciting
new
perspectives
this
burgeoning
also
summarizes
recent
representative
applications
with
excellent
properties.
Conclusions
are
provided
from
five
aspects
concise
summary,
mechanism,
biofabrication
upgraded
applications,
synergistic
methodology.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(5), P. 4008 - 4018
Published: Jan. 26, 2024
Mixed
ion–electron
conductive
(MIEC)
bioelectronics
has
emerged
as
a
state-of-the-art
type
of
for
bioelectrical
signal
monitoring.
However,
existing
MIEC
is
limited
by
delamination
and
transmission
defects
in
signals.
Herein,
topological
MXene
network
enhanced
hydrogel
that
simultaneously
exhibits
both
electrical
mechanical
property
enhancement
while
maintaining
adhesion
biocompatibility,
providing
an
ideal
electrophysiological
monitoring,
introduced.
Compared
with
nontopology
bioelectronics,
the
topology
increases
dynamic
stability
factor
8.4
10.1
reduces
energy
dissipation
20.2.
Besides,
topology-enhanced
low
impedance
(<25
Ω)
at
physiologically
relevant
frequencies
negligible
fluctuation
after
5000
stretch
cycles.
The
creation
multichannel
high-fidelity
muscle
action
mapping
gait
recognition
was
made
possible
achieving
such
performance.
Macromolecular Rapid Communications,
Journal Year:
2024,
Volume and Issue:
45(11)
Published: Feb. 24, 2024
Abstract
Hydrogels,
key
in
biomedical
research
for
their
hydrophilicity
and
versatility,
have
evolved
with
hydrogel
microspheres
(HMs)
of
micron‐scale
dimensions,
enhancing
role
minimally
invasive
therapeutic
delivery,
tissue
repair,
regeneration.
The
recent
emergence
nanomaterials
has
ushered
a
revolutionary
transformation
the
field,
which
demonstrates
tremendous
potential
targeted
therapies,
biological
imaging,
disease
diagnostics.
Consequently,
integration
advanced
nanotechnology
promises
to
trigger
new
revolution
realm
hydrogels.
HMs
loaded
combine
advantages
both
hydrogels
nanomaterials,
enables
multifaceted
functionalities
such
as
efficient
drug
sustained
release,
therapy,
lubrication,
biochemical
detection,
medical
biosensing
monitoring,
micro‐robotics.
Here,
this
review
comprehensively
expounds
upon
commonly
used
classifications.
Then,
it
provides
comprehensive
insights
into
raw
materials
preparation
methods
HMs.
Besides,
common
strategies
employed
achieve
nano‐micron
combinations
are
summarized,
latest
applications
these
combined
field
elucidated.
Finally,
valuable
future
design
development
provided.
