Oxidative Stress, Inflammation, Gut Dysbiosis: What Can Polyphenols Do in Inflammatory Bowel Disease?

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 967 - 967

Published: April 20, 2023

Inflammatory bowel disease (IBD) is a long-term, progressive, and recurrent intestinal inflammatory disorder. The pathogenic mechanisms of IBD are multifaceted associated with oxidative stress, unbalanced gut microbiota, aberrant immune response. Indeed, stress can affect the progression development by regulating homeostasis microbiota Therefore, redox-targeted therapy promising treatment option for IBD. Recent evidence has verified that Chinese herbal medicine (CHM)-derived polyphenols, natural antioxidants, able to maintain redox equilibrium in tract prevent abnormal radical responses. Here, we provide comprehensive perspective implementing antioxidants as potential candidate medications. In addition, demonstrate novel technologies stratagems promoting antioxidative properties CHM-derived including delivery systems, chemical modifications, combination strategies.

Language: Английский

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Resveratrol as a Promising Nutraceutical: Implications in Gut Microbiota Modulation, Inflammatory Disorders, and Colorectal Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3370 - 3370

Published: March 16, 2024

Natural products have been a long-standing source for exploring health-beneficial components from time immemorial. Modern science has had renewed interest in natural-products-based drug discovery. The quest new potential secondary metabolites or enhanced activities existing molecules remains pertinent topic research. Resveratrol belongs to the stilbenoid polyphenols group that encompasses two phenol rings linked by ethylene bonds. Several plant species and foods, including grape skin seeds, are primary of this compound. is known possess potent anti-inflammatory, antiproliferative, immunoregulatory properties. Among notable bioactivities associated with resveratrol, its pivotal role safeguarding intestinal barrier highlighted capacity prevent inflammation regulate gut microbiome. A better understanding how oxidative stress can be controlled using resveratrol capability protect microbiome perspective shed more light on physiological conditions. Additionally, exhibits antitumor activity, proving cancer treatment prevention. Moreover, cardioprotective, vasorelaxant, phytoestrogenic, neuroprotective benefits also reported. pharmaceutical industry continues encounter difficulties administering owing inadequate bioavailability poor solubility, which must addressed simultaneously. This report summarizes currently available literature unveiling pharmacological effects resveratrol.

Language: Английский

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Natural polyphenols-gut microbiota interactions and effects on glycolipid metabolism via polyphenols-gut-brain axis: A state-of-the-art review

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 140, P. 104171 - 104171

Published: Sept. 12, 2023

Language: Английский

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Mechanisms of Qingyi Decoction in Severe Acute Pancreatitis-Associated Acute Lung Injury via Gut Microbiota: Targeting the Short-Chain Fatty Acids-Mediated AMPK/NF-κB/NLRP3 Pathway

Microbiology Spectrum, Journal Year: 2023, Volume and Issue: 11(4)

Published: June 20, 2023

The pivotal roles of gut microbiota in severe acute pancreatitis-associated lung injury (SAP-ALI) are increasingly revealed, and recent discoveries the gut-lung axis have provided potential approaches for treating SAP-ALI. Qingyi decoction (QYD), a traditional Chinese medicine (TCM), is commonly used clinical to treat However, underlying mechanisms remain be fully elucidated. Herein, by using caerulein plus lipopolysaccharide (LPS)-induced SAP-ALI mice model antibiotics (Abx) cocktail-induced pseudogermfree model, we tried uncover administration QYD explored its possible mechanisms. Immunohistochemical results showed that severity intestinal barrier functions could affected relative depletion bacteria. composition was partially recovered after treatment with decreased Firmicutes/Bacteroidetes ratio increased abundance short-chain fatty acids (SCFAs)-producing Correspondingly levels SCFAs (especially propionate butyrate) feces, gut, serum, lungs were observed, generally consistent changes microbes. Western-blot analysis RT-qPCR indicated AMPK/NF-κB/NLRP3 signaling pathway activated oral QYD, which found possibly related regulatory effects on intestine lungs. In conclusion, our study provides new insights into through modulating has prospective practical value use future. IMPORTANCE Gut affects function. During SAP, significant increase pathogens (Escherichia, Enterococcus, Enterobacter, Peptostreptococcus, Helicobacter) observed. At same time, pathogenic bacteria SCFAs-producing (Bacteroides, Roseburia, Parabacteroides, Prevotella, Akkermansia). addition, mediated along may play an essential role preventing pathogenesis SAP-ALI, allows reduced systemic inflammation restoration barrier.

Language: Английский

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Ameliorative effect of bound polyphenols in mung bean coat dietary fiber on DSS-induced ulcerative colitis in mice: the intestinal barrier and intestinal flora

Food & Function, Journal Year: 2024, Volume and Issue: 15(8), P. 4154 - 4169

Published: Jan. 1, 2024

Bound polyphenols in mung bean coat dietary fiber alleviate ulcerative colitis mice by protecting intestinal barrier and regulating flora.

Language: Английский

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Resveratrol improves diabetic kidney disease by modulating the gut microbiota-short chain fatty acids axis in db/db mice

International Journal of Food Sciences and Nutrition, Journal Year: 2024, Volume and Issue: 75(3), P. 264 - 276

Published: Jan. 18, 2024

Diabetic kidney disease is associated with the dysbiosis of gut microbiota and its metabolites. db/db mice were fed chow diet or without 0.4% resveratrol for 12 weeks, after which microbiota, faecal short-chain fatty acids (SCFAs), renal fibrosis analysed. Resveratrol ameliorated progression diabetic alleviated tubulointerstitial fibrosis. Further studies showed that was modulated by resveratrol, characterised expansion SCFAs-producing bacteria Faecalibaculum Lactobacillus, increased concentrations SCFAs (especially acetic acid) in faeces. Moreover, transplantation experiments found alteration contributed to prevention disease. Acetate treatment proteinuria, glomerulosclerosis mice. Overall, improved suppressing fibrosis, may be involved, at least part, regulation microbiota-SCFAs axis.

Language: Английский

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Resveratrol attenuates intestinal epithelial barrier dysfunction via Nrf2/HO‐1 pathway in dextran sulfate sodium‐induced Caco‐2 cells

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(2)

Published: Feb. 1, 2024

The intestinal tract serves as an innate barrier, safeguarding the internal milieu from microorganisms and toxins. Various inflammatory diseases have a strong association with barrier dysfunction. primary functional cells within tract, epithelial (IECs) their tight junctions (TJs), are crucial in preserving integrity of this mechanical barrier. Resveratrol (Res), plant-derived phenolic compound, exhibits range health-promoting benefits attributed to its anti-inflammatory properties. This study aims examine Res's efficacy bolstering IECs function.

Language: Английский

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2′-Fucosyllactose Promotes Colonization of Akkermansia muciniphila and Prevents Colitis In Vitro and in Mice

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(9), P. 4765 - 4776

Published: Feb. 23, 2024

Akkermansia muciniphila is a potential candidate for ulcerative colitis prevention. Considering that it utilizes 2′-fucosyllactose (2′FL) growth, 2′FL can be used to enrich the abundance of A. in feces. However, whether crosswalk between and promote intestinal colonization remains unclear. In this study, we explored effect underlying mechanism on vitro vivo as well its alleviating colitis. Our results revealed serve carbon source support growth increase cell-surface hydrophobicity expression genes coding fibronectin-binding autotransporter adhesin adhesion Caco2/HT29 methotrexate (MTX) cells but not galactooligosaccharides (GOS) glucose. Moreover, could host mucin formation MTX GOS Furthermore, significantly gut alleviate mice. Overall, interplay expected provide an advantageous ecological niche so confer further health benefits against

Language: Английский

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Unlocking Gut Health: The Potent Role of Stilbenoids in Intestinal Homeostasis

Animals, Journal Year: 2025, Volume and Issue: 15(3), P. 417 - 417

Published: Feb. 3, 2025

Stilbenoids are a class of naturally occurring phenolic compounds found in various plant species, characterized by stilbene backbone with diverse substituents that confer range biological activities. These exhibit antioxidant, anti-inflammatory, and antimicrobial properties, making them promising candidates for improving intestinal health. The tract plays critical role nutrient digestion, absorption, immune defense, maintaining its integrity is vital animal growth. contribute to gut health enhancing morphology, supporting mucosal responses, regulating microbiota composition, modulating metabolic pathways, mitochondrial This review provides comprehensive analysis key stilbenoids, including resveratrol, pterostilbene, piceatannol, oxyresveratrol, focusing on their effects regulatory mechanisms. By highlighting roles mitigating inflammation promoting function, this basis the practical application stilbenoids husbandry.

Language: Английский

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Limosilactobacillus fermentum HF06‐derived paraprobiotic and postbiotic alleviate intestinal barrier damage and gut microbiota disruption in mice with ulcerative colitis

Journal of the Science of Food and Agriculture, Journal Year: 2023, Volume and Issue: 104(3), P. 1702 - 1712

Published: Oct. 18, 2023

Paraprobiotics and postbiotics have shown potential in the treatment of ulcerative colitis (UC). However, their vivo application is still its infancy mechanisms action are not well understood.

Language: Английский

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