Stimuli responsive nanosonosensitizers for sonodynamic therapy

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 361, P. 547 - 567

Published: Aug. 15, 2023

Language: Английский

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Achieving Clearance of Drug‐Resistant Bacterial Infection and Rapid Cutaneous Wound Regeneration Using an ROS‐Balancing‐Engineered Heterojunction

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(16)

Published: Feb. 1, 2024

Abstract Intractable infected microenvironments caused by drug‐resistant bacteria stalls the normal course of wound healing. Sono‐piezodynamic therapy (SPT) is harnessed to combat pathogenic bacteria, but superabundant reactive oxygen species (ROS) generated during SPT inevitably provoke severe inflammatory response, hindering tissue regeneration. Consequently, an intelligent nanocatalytic membrane composed poly(lactic‐co‐glycolic acid) (PLGA) and black phosphorus /V 2 C MXene bio‐heterojunctions (2D ‐bioHJs) devised. Under ultrasonication, 2D ‐bioHJs effectively eliminate disrupting metabolism electron transport chain (ETC). When ultrasonication ceases, they enable elimination SPT‐generated ROS. The act as a “lever” that achieves balance between ROS generation annihilation, delivering both antibacterial anti‐inflammatory properties engineered membrane. More importantly, in vivo assays corroborate membranes transform stalled chronic environment into regenerative one eradicating bacterial population, dampening NF‐κB pathway promoting angiogenesis. As envisaged, this work demonstrates novel tactic arm with programmed effects remedy refractory wounds from drug‐fast bacteria.

Language: Английский

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Synergistic Interaction between Metal Single‐Atoms and Defective WO_3−x Nanosheets for Enhanced Sonodynamic Cancer Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(23)

Published: Feb. 27, 2024

Abstract Although metal single‐atom (SA)‐based nanomaterials are explored as sonosensitizers for sonodynamic therapy (SDT), they normally exhibit poor activities and need to combine with other therapeutic strategies. Herein, the deposition of SAs on oxygen vacancy (OV)‐rich WO 3− x nanosheets generate a synergistic effect efficient SDT is reported. Crystalline 3 OV‐rich first prepared by simple calcination ·H 2 O under an air N atmosphere, respectively. Pt, Cu, Fe, Co, Ni then deposited obtain SA‐decorated nanocomposites (M‐WO ). Importantly, Cu‐WO sonosensitizer exhibits much higher activity ultrasound (US)‐induced production reactive species than that Cu , which also M‐WO nanosheets. Both experimental theoretical results suggest excellent performance should be attributed between OVs. Therefore, after polyethylene glycol modification, can quickly kill cancer cells in vitro effectively eradicate tumors vivo US irradiation. Transcriptome sequencing analysis further molecular validation ‐mediated SDT‐activated apoptosis TNF signaling pathways potential drivers tumor induction.

Language: Английский

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Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(13), P. 8307 - 8472

Published: June 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Language: Английский

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A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Language: Английский

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Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 21, 2024

Abstract Cancer cells typically display redox imbalance compared with normal due to increased metabolic rate, accumulated mitochondrial dysfunction, elevated cell signaling, and accelerated peroxisomal activities. This may regulate gene expression, alter protein stability, modulate existing cellular programs, resulting in inefficient treatment modalities. Therapeutic strategies targeting intra‐ or extracellular states of cancer at varying state progression trigger programmed death if exceeded a certain threshold, enabling therapeutic selectivity overcoming resistance radiotherapy chemotherapy. Nanotechnology provides new opportunities for modulating their excellent designability high reactivity. Various nanomaterials are widely researched enhance highly reactive substances (free radicals) production, disrupt the endogenous antioxidant defense systems, both. Here, physiological features described challenges illustrated. Then, that classified elaborated upon based on ability target regulations. Finally, future perspectives this field proposed. It is hoped review guidance design nanomaterials‐based approaches involving therapy, especially cancers resistant chemotherapy, etc.

Language: Английский

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Narrow Bandgap Schottky Heterojunction Sonosensitizer with High Electron–Hole Separation Boosted Sonodynamic Therapy in Bladder Cancer

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)

Published: March 29, 2024

Abstract Sonodynamic therapy (SDT) is applied to bladder cancer (BC) given its advantages of high depth tissue penetration and nontoxicity due the unique anatomical location near abdominal surface. However, low electron–hole separation efficiency wide bandgap sonosensitizers limit effectiveness SDT. This study aims develop a TiO 2 ‐Ru‐PEG Schottky heterojunction sonosensitizer with narrow for SDT in BC. Density functional theory (DFT) calculations experiments collectively demonstrate that reduced characteristic crystalline‐amorphous interface formed by deposition ruthenium (Ru) within shell layer . Thanks enhancement oxygen adsorption efficient pairs, promotes generation reactive species (ROS) under ultrasound (US) irradiation, resulting cell cycle arrest apoptosis tumor cells. The vivo results prove boosted subcutaneous orthotopic models while exhibiting good safety. adopts complex optimizing sonosensitizers, contributing progress improvement strategies presenting paradigm BC therapy.

Language: Английский

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Targeted Delivery of Active Sites by Oxygen Vacancy-Engineered Bimetal Silicate Nanozymes for Intratumoral Aggregation-Potentiated Catalytic Therapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(2), P. 1516 - 1530

Published: Jan. 3, 2024

Biodegradable silicate nanoconstructs have aroused tremendous interest in cancer therapeutics due to their variable framework composition and versatile functions. Nevertheless, low intratumoral retention still limits practical application. In this study, oxygen vacancy (OV)-enriched bimetallic nanozymes with Fe–Ca dual active sites via modification of oxidized sodium alginate gallic acid (GA) loading (OFeCaSA-V@GA) were developed for targeted aggregation-potentiated therapy. The band gap silica markedly decreased from 2.76 1.81 eV by codoping Fe3+ Ca2+, enabling its excitation a 650 nm laser generate reactive species. OV that occurred the hydrothermal synthetic stage OFeCaSA-V@GA can anchor metal ions form an atomic phase, offering massive fabrication method single-atom nanozymes. Density functional theory results reveal Ca promote adsorption H2O2, Fe accelerate dissociation thereby realizing synergetic catalytic effect. More importantly, delivery induce morphological transformation at tumor sites, leading high (the highest rate is 36.3%) theranostic components cells. Thus, finding may offer ingenious protocol designing engineering highly efficient long-retention nanodrugs.

Language: Английский

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Endoplasmic Reticulum‐Targeting Iridium(III) Nanosonosensitizer Amplifies Immunogenic Cell Death for Boosted Tumor Sono‐Immunotherapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(26)

Published: Feb. 27, 2024

Abstract Reactive oxygen species (ROS)‐induced endoplasmic reticulum (ER) stress in sonodynamic therapy (SDT) can elicit immunogenic cell death (ICD)‐initiated antitumor immunity for augmented sono‐immunotherapy. However, unsatisfactory activity and mediocre ER induction ability of sonosensitizers essentially restrict SDT efficacy ICD stimulation. Herein, a versatile ER‐targeting Iridium(III) nanosonosensitizer is developed as superior inducer boosted tumor An ingenious cholic acid (CA)‐functionalized sonosensitizer Ir‐CA well‐designed skillfully crosslinked with human serum albumin (HSA) to form HSA@Ir‐CA. With high stability, favorable tumor‐targeting ability, reduction‐responsiveness, HSA@Ir‐CA preferentially accumulates sites enhanced cellular uptake, followed by rapid disassembly responding intracellular reductive environment. The uncaged selectively accumulate precisely disrupt situ produced type I II ROS upon US irradiation high‐efficiency SDT. Moreover, the maximized eminently amplifies evoke robust systemic immunity, inhibiting growths primary/distant tumor, lung metastasis, recurrence. This combined immune checkpoint inhibitor (αPD‐L1) further achieves reinforced therapeutic outcome against immunologically “cold” tumor. study presents an effective paradigm optimize amplify ICD‐initiated responses

Language: Английский

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“Edge in-situ heterogeneous” BiOI based on defect engineering and non-noble metal deposition: Boosting visible-light photocatalytic sterilization

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 491, P. 152071 - 152071

Published: May 8, 2024

Language: Английский

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