Nano Research, Journal Year: 2022, Volume and Issue: 16(1), P. 715 - 734
Published: Sept. 16, 2022
Language: Английский
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 17, 2025
We report the assembly of poly(ethylene glycol) nanoparticles (PEG NPs) and optimize their surface chemistry to minimize formation protein coronas immunogenicity for improved biodistribution. PEG NPs cross-linked with disulfide bonds are synthesized utilizing zeolitic imidazolate framework-8 as templates, which subsequently modified molecules different end groups (carboxyl, methoxy, or amino) vary chemistry. Among modifications, amino residual carboxyl form a pair zwitterionic structures on NPs, adsorption proteins (e.g., immunoglobulin, complement proteins) maximize blood circulation time. The influence preexisting antibodies in mice pharmacokinetics is negligible, demonstrates resistance anti-PEG inhibition accelerated clearance phenomenon. This research highlights importance PEGylated design delivery systems reveals translational potential cancer therapy.
Language: Английский
Citations
2
Hybrid Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100406 - 100406
Published: Feb. 1, 2025
Language: Английский
Citations
2
Progress in Materials Science, Journal Year: 2022, Volume and Issue: 130, P. 101000 - 101000
Published: July 15, 2022
Language: Английский
Citations
68
Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 145, P. 146 - 158
Published: April 2, 2022
Language: Английский
Citations
44
Small, Journal Year: 2023, Volume and Issue: 19(11)
Published: Jan. 1, 2023
Abstract The combination of photodynamic therapy (PDT) and chemotherapy (chemo‐photodynamic therapy) for enhancing cancer therapeutic efficiency has attracted tremendous attention in the recent years. However, limitations, such as low local concentration, non‐suitable treatment light source, uncontrollable release agents, result reduced combined efficacy. This study considered adenosine triphosphate (ATP), which is highly upregulated tumor cells, a biomarker developed ingenious ATP‐activated nanoparticles (CDNPs) that are directly self‐assembled from near‐infrared photosensitizer (Cy‐I) amphiphilic Cd(II) complex (DPA‐Cd). After selective entry into positively charged CDNPs would escape lysosomes be disintegrated by high ATP concentration cytoplasm. released Cy‐I capable producing single oxygen ( 1 O 2 ) PDT with 808 nm irradiation DPA‐Cd can concurrently function chemotherapy. Irradiation lead to ablation tumor‐bearing mice after intravenous injection CDNPs. carrier‐free nanoparticle offers new platform chemo‐photodynamic therapy.
Language: Английский
Citations
32
Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100572 - 100572
Published: Feb. 1, 2023
The extracellular matrix (ECM), an integral component of all organs, is inherently tissue adhesive and plays a pivotal role in regeneration remodeling. However, man-made three-dimensional (3D) biomaterials that are designed to mimic ECMs do not intrinsically adhere moisture-rich environments often lack open macroporous architecture required for facilitating cellularization integration with the host post-implantation. Furthermore, most these constructs usually entail invasive surgeries potentially risk infection. To address challenges, we recently engineered biomimetic cryogel scaffolds syringe injectable while exhibiting unique physical properties, including strong bioadhesive properties tissues organs. These catechol-containing cryogels were prepared from naturally-derived polymers such as gelatin hyaluronic acid functionalized mussel-inspired dopamine (DOPA) impart properties. We found using glutathione antioxidant incorporating DOPA into via PEG spacer arm led highest adhesion improved overall, whereas DOPA-free weakly adhesive. As shown by qualitative quantitative tests, DOPA-containing able strongly several animal organs heart, small intestine, lung, kidney, skin. unoxidized (i.e., browning-free) showed negligible cytotoxicity toward murine fibroblasts prevented
Language: Английский
Citations
27
ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 2815 - 2827
Published: Jan. 16, 2024
Improving the performance of nanocarriers remains a major challenge in clinical translation nanomedicine. Efforts to optimize nanoparticle formulations typically rely on tuning surface density and thickness stealthy polymer coatings, such as poly(ethylene glycol) (PEG). Here, we show that modulating topography PEGylated nanoparticles using bottlebrush block copolymers (BBCPs) significantly enhances circulation tumor accumulation, providing an alternative strategy improve coatings. Specifically, with rough achieve high cell uptake vivo due superior extravasation distribution compared conventional smooth-surfaced based linear copolymers. Furthermore, profoundly impacts interaction serum proteins, resulting adsorption fundamentally different proteins onto rough-surfaced formed from BBCPs. We envision controlling will enable design improved various biomedical applications.
Language: Английский
Citations
13
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(19), P. 25236 - 25245
Published: May 3, 2024
Constructing antifouling surfaces is a crucial technique for optimizing the performance of devices such as water treatment membranes and medical in practical environments. These are achieved by modification with hydrophilic polymers. Notably, zwitterionic (ZI) polymers have attracted considerable interest because their ability to form robust hydration layer inhibit adsorption foulants. However, importance molecular weight density ZI polymer on property partially understood, surface design still retains an empirical flavor. Herein, we individually assessed influence protein through machine learning. The results corroborated that more strongly influenced than weight. Furthermore, distribution predicted against enabled us determine conditions enhanced (or weaken) antifouling. relevance this prediction method was also demonstrated estimating over wide range ionic strengths. Overall, machine-learning-based approach expected contribute tool optimized functionalization materials, extending beyond applications brushes.
Language: Английский
Citations
10
Progress in Polymer Science, Journal Year: 2024, Volume and Issue: 156, P. 101870 - 101870
Published: Aug. 10, 2024
Language: Английский
Citations
10
Science Advances, Journal Year: 2024, Volume and Issue: 10(4)
Published: Jan. 24, 2024
The constant interplay and information exchange between cells the microenvironment are essential to their survival ability execute biological functions. To date, a few leading technologies such as traction force microscopy, optical/magnetic tweezers, molecular tension–based fluorescence microscopy broadly used in measuring cellular forces. However, considerable limitations, regarding sensitivity ambiguities data interpretation, hindering our thorough understanding of mechanobiology. Here, we propose an innovative approach, namely, quantum-enhanced diamond tension (QDMTM), precisely quantify integrin-based cell adhesive Specifically, construct force-sensing platform by conjugating magnetic nanotags labeled, force-responsive polymer surface membrane containing nitrogen-vacancy centers. Notably, forces will be converted into detectable variations QDMTM. After careful validation, achieved quantitative mapping correlating measurement with established theoretical model. We anticipate method can routinely studies like cell-cell or cell-material interactions mechanotransduction.
Language: Английский
Citations
9