An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 28, 2025

Abstract Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in microenvironment of wound infection to promote healing. In this study, a multifunctional hydrogel delivery (HA@TA-Okra) was constructed through integration hyaluronic acid methacrylate (HAMA) matrix with tannic (TA) and okra extract. The composition structural characteristics HA@TA-Okra its unique advantages treatment diverse wounds were systematically evaluated. TA, due chemical structure, is able anchor within HAMA network interactions cross-linking, conferring exceptional mechanical strength stability hydrogel. Both TA extract possess antioxidant properties, when they two acts synergistically scavenge free radicals, enhance action, diminishing risk infection. vitro experiments revealed has superior such as rapid gel response, remarkable swelling regulation, potent ability. Furthermore, significantly outperformed conventional dressings terms hemostatic performance rat hemorrhage model. We further evaluated repair role vivo by establishing an animal model full-thickness skin defects infected total defects. results confirmed positive effects fighting bacterial infection, reducing inflammation promoting summary, exhibits comprehensive properties antibacterial, which potential application field tissue medicine. Graphical

Language: Английский

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Gelatin-based adaptive injectable nanocomposite hydrogel for closure of irregular wounds and immunoregulation in diabetic wound healing

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144313 - 144313

Published: May 1, 2025

Language: Английский

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Dual decoration of quinoa protein isolate by different dietary polyphenols with covalent and noncovalent approaches: Structure characterization, conformational changes and functional properties

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 156, P. 110376 - 110376

Published: July 1, 2024

Language: Английский

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Microenvironment-Responsive Antibacterial, Anti-Inflammatory, and Antioxidant Pickering Emulsion Stabilized by Curcumin-Loaded Tea Polyphenol Particles for Accelerating Infected Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(34), P. 44467 - 44484

Published: Aug. 14, 2024

Multiphase Pickering emulsions, including two or more active agents, are of great importance to effectively manage complicated wounds. However, current strategies based on emulsions still unsatisfying since they involve only stabilization by inactive particles and encapsulation the hydrophobic drugs in oil phase. Herein, thyme essential (TEO) was encapsulated shell functional tea polyphenol (TP)-curcumin (Cur) nanoparticles (TC NPs) exemplarily develop a novel emulsion (TEO/TC PE). Hydrophobic Cur loaded with hydrophilic TP obtain TC NPs, under homogenization, these NPs adsorbed surface TEO droplets form stable core-shell structure. Owing such an oil-in-water (O/W) structure, sequential release first from pH-responsive disintegrated then leaked yielded synergetic functions TEO/TC PE, leading enhanced antibacterial, biofilm elimination, antioxidant, anti-inflammatory activities. This injectable PE applied treat infected full-thickness skin defects, satisfactory wound healing effects were achieved rapid angiogenesis, collagen deposition, regeneration. The present constituted entirely plant-sourced products is biosafe expected spearhead future development dressings.

Language: Английский

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Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Diabetes significantly impairs the body's wound‐healing capabilities, leading to chronic, infection‐prone wounds. These wounds are characterized by hyperglycemia, inflammation, hypoxia, variable pH levels, increased matrix metalloproteinase activity, oxidative stress, and bacterial colonization. complex conditions complicate effective wound management, prompting development of advanced diabetic care strategies that exploit specific characteristics such as acidic pH, high glucose stress trigger controlled drug release, thereby enhancing therapeutic effects dressings. Among solutions, hydrogels emerge promising due their stimuli‐responsive nature, making them highly for managing these The latest advancements in mono/multi‐stimuli‐responsive smart showcase superiority potential healthcare materials, highlighted relevant case studies. However, traditional dressings fall short meeting nuanced needs wounds, adjustable adhesion, easy removal, real‐time status monitoring, dynamic release adjustment according wound's conditions. Responsive represent a significant leap forward proficient sensing responding environment, offering more targeted approach treatment. This review highlights recent dressing, delivery, emphasizing role improving healing. It addresses ongoing challenges future directions, aiming guide clinical adoption.

Language: Английский

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Amorphous curcumin-based hydrogels to reduce the incidence of post-surgical intrauterine adhesions

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract The incidence of intrauterine adhesions (IUA) has increased with the rising utilization surgery. postoperative physical barrier methods commonly used, such as balloons and other fillers, have limited effectiveness may even cause further damage to remaining endometrial tissue. Herein, we developed an injectable thermosensitive hydrogel using Pluronic F127/F68 pharmaceutical excipients curcumin a natural active molecule. effectively addresses solubility low bioavailability issues associated curcumin. In vitro, drug release assays revealed that amorphous promotes dissolution sustained vitro experiments reveal high biocompatibility its ability enhance vascular formation while inhibiting expression fibrotic factor TGF-β1. To assess preventing IUAs, in vivo were conducted IUA rats compared class III medical device, new-crosslinked hyaluronic acid (NCHA) gel. According study, is more effective than NCHA group improving regeneration endometrium, increasing blood supply endometrium reducing abnormal deposition fibrin, thus effectively. This study provides promising strategy for treating IUA.

Language: Английский

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Review: Advances in multifunctional hydrogels based on carbohydrate polymer and protein in the treatment of diabetic wounds

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142693 - 142693

Published: March 1, 2025

Language: Английский

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Astragalus polysaccharide/carboxymethyl chitosan/sodium alginate based electroconductive hydrogels for diabetic wound healing and muscle function assessment

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 350, P. 123058 - 123058

Published: Nov. 26, 2024

Language: Английский

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Recent Advances in Smart Self‐Assembled Bioinspired Hydrogels: A Bridging Weapon for Emerging Health Care Applications from Bench to Bedside

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: 45(17)

Published: May 28, 2024

Stimuli-responsive low molecular weight hydrogel interventions for Biomedical challenges are a rapidly evolving paradigm in the bottom-up approach recently. Peptide-based self-assembled nano biomaterials present safer alternatives to their non-degradable counterparts as demanded today's most urged clinical needs.Although plethora of work has already been accomplished, programming hydrogelators with appropriate functionalities requires better understanding impact macromolecular structure peptides and subsequently, nanostructures remain unidentified. Henceforth this review focuses on two aspects: Firstly, underlying guidelines building biomimetic strategies tailor scaffolds leading hydrogelation along role non-covalent interactions that key components various self-assembly processes. In second section, it is aimed bring together recent achievements designer assembly concerning self-aggregation behaviour applications mainly biomedical arena like drug delivery carrier design, antimicrobial, anti-inflammatory well wound healing materials. Furthermore, anticipated article will provide conceptual demonstration different approaches taken towards construction these task-specific hydrogels. Finally, collective effort among material scientists required pave path entrance intelligent materials into medicine from bench bedside.

Language: Английский

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Advances and Challenges in Immune-Modulatory Biomaterials for Wound Healing Applications

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 990 - 990

Published: July 26, 2024

Wound healing progresses through three distinct stages: inflammation, proliferation, and remodeling. Immune regulation is a central component throughout, crucial for orchestrating inflammatory responses, facilitating tissue repair, restraining scar formation. Elements such as mitochondria, reactive oxygen species (ROS), macrophages, autophagy, ferroptosis, cytokines collaboratively shape immune in this process. Skin wound dressings, recognized their ability to augment biomaterials’ immunomodulatory characteristics via antimicrobial, antioxidative, pro- or anti-inflammatory, tissue-regenerative capacities, have garnered heightened attention. Notwithstanding, lack of comprehensive research addressing how these dressings attain properties the mechanisms thereof persists. Hence, paper pioneers systematic review biomaterials, emphasizing underlying immunological mechanisms. It begins by highlighting importance peculiarities obstacles faced skin injury recovery. This segment explores impact metabolism, infections, systemic illnesses, local immobilization on response during healing. Subsequently, examines spectrum biomaterials utilized therapy, including hydrogels, aerogels, electrospun nanofiber membranes, collagen scaffolds, microneedles, sponges, 3D-printed constructs. elaborates approaches employed materials, focusing mitochondrial ROS modulation, autophagic processes, macrophage influence Acknowledging challenge antibiotic resistance, also summarizes promising plant-based alternatives biomaterial integration, curcumin. In its concluding sections, charts recent advancements prospects that accelerate modulation. includes exploring transplantation morphology optimization, metal ion incorporation, electrostimulation-enabled control, benefits composite materials immune-regulatory dressings. The ultimate objective establish theoretical foundation guide future investigations realm related science disciplines.

Language: Английский

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