Macromolecular Bioscience,
Journal Year:
2024,
Volume and Issue:
24(6)
Published: March 28, 2024
Abstract
Spinal
cord
injury,
traumatic
brain
and
neurosurgery
procedures
usually
lead
to
neural
tissue
damage.
Self‐assembled
peptide
(SAP)
hydrogels,
a
type
of
innovative
hierarchical
nanofiber‐forming
sequences
serving
as
hydrogelators,
have
emerged
promising
solution
for
repairing
defects
promoting
regeneration.
SAPs
possess
numerous
features,
such
adaptable
morphologies,
biocompatibility,
injectability,
tunable
mechanical
stability,
mimicking
the
native
extracellular
matrix.
This
review
explores
capacity
cell
regeneration
examines
critical
aspects
in
neuroregeneration,
including
their
biochemical
composition,
topology,
behavior,
conductivity,
degradability.
Additionally,
it
delves
into
latest
strategies
involving
central
or
peripheral
engineering.
Finally,
prospects
SAP
hydrogel
design
development
realm
neuroregeneration
are
discussed.
MRS Bulletin,
Journal Year:
2023,
Volume and Issue:
48(5), P. 495 - 505
Published: May 1, 2023
Abstract
Hydrogels
are
a
class
of
soft
materials,
which
display
unique
biomimetic
properties
to
biological
tissues.
Their
mechanical
properties,
high
water
content,
and
porosity
resemble
that
extracellular
matrix
so
cell
growth
proliferation
can
be
reliably
supported.
In
vitro
studies
report
mechanosensitive
cells
found
in
the
central
nervous
system,
such
as
astrocytes
glia,
reduced
activation,
thus
promoting
lower
foreign
body
reaction,
when
cultured
on
hydrogel
substrates
<1-kPa
modulus.
This
observation
provides
an
opportunity
explore
whether
hydrogels
should
integrated
or
form
implantable
neural
interfaces
offer
long-term
biointegrated
neurotechnologies.
article
highlights
recent
progress
materials
associated
technologies
for
design
bioelectronics.
Essential
structural,
mechanical,
electronical
composite
briefly
reviewed.
Manufacturing
methods
suitable
these
multiscale
multifunctional
presented.
The
final
section
presents
hydrogel-based
bioelectronics
brain
outlines
current
challenges
future
opportunities.
Graphical
abstract
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 7305 - 7333
Published: Dec. 1, 2023
Abstract:
Spinal
cord
injury
(SCI)
treatment
represents
a
major
challenge
in
clinical
practice.
In
recent
years,
the
rapid
development
of
neural
tissue
engineering
technology
has
provided
new
therapeutic
approach
for
spinal
repair.
Implanting
functionalized
electroconductive
hydrogels
(ECH)
area
been
shown
to
promote
axonal
regeneration
and
facilitate
generation
neuronal
circuits
by
reshaping
microenvironment
SCI.
ECH
not
only
intercellular
electrical
signaling
but,
when
combined
with
stimulation,
enable
transmission
signals
electroactive
activate
bioelectric
pathways,
thereby
promoting
Therefore,
implantation
into
damaged
tissues
can
effectively
restore
physiological
functions
related
conduction.
This
article
focuses
on
dynamic
pathophysiological
changes
SCI
discusses
mechanisms
stimulation/signal
process
By
examining
activity
during
nerve
repair,
we
provide
insights
behind
stimulation
We
classify
conductive
biomaterials,
offer
an
overview
current
applications
research
progress
repair
regeneration,
aiming
reference
future
explorations
developments
strategies.
Keywords:
engineering,
signal,
Frontiers in Cell and Developmental Biology,
Journal Year:
2022,
Volume and Issue:
10
Published: July 5, 2022
Stem
cell-based
therapeutics
have
gained
tremendous
attention
in
recent
years
due
to
their
wide
range
of
applications
various
degenerative
diseases,
injuries,
and
other
health-related
conditions.
Therapeutically
effective
bone
marrow
stem
cells,
cord
blood-
or
adipose
tissue-derived
mesenchymal
cells
(MSCs),
embryonic
(ESCs),
more
recently,
induced
pluripotent
(iPSCs)
been
widely
reported
many
preclinical
clinical
studies
with
some
promising
results.
However,
these
cell-only
transplantation
strategies
are
hindered
by
the
harsh
microenvironment,
limited
cell
viability,
poor
retention
transplanted
at
sites
injury.
In
fact,
a
number
that
less
than
5%
retained
site
injury
on
first
day
after
transplantation,
suggesting
extremely
low
(<1%)
viability
cells.
this
context,
3D
porous
fibrous
national
polymers
(collagen,
fibrin,
hyaluronic
acid,
chitosan)-based
scaffold
appropriate
mechanical
features
biocompatibility
can
be
used
overcome
limitations
supporting
adhesion,
survival,
proliferation,
differentiation
as
well
providing
elegant
3-dimensional
(3D)
tissue
microenvironment.
Therefore,
engineering
using
natural
synthetic
biomimetics
provides
novel
therapeutic
opportunities
for
diseases
Here,
we
summarized
involving
types
tissue-engineering
different
diseases.
We
also
reviewed
use
scaffolds
optimization
strategies.
