Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer DOI Creative Commons
Yun Yang, Qingya Liu, Meng Wang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: June 11, 2024

Abstract Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens, including prolonged circulation in the bloodstream, specific cell recognition targeting capabilities, potential for immunotherapy. Herein, we introduce a biomimetic nanodrug platform termed MPB-3BP@CM NPs. Comprising microporous Prussian blue (MPB NPs) serving as both photothermal sensitizer carrier 3-bromopyruvate (3BP), these are cloaked genetically programmable displaying variants of signal regulatory protein α (SIRPα) with enhanced affinity to CD47. As result, NPs inherit characteristics original membrane, exhibiting an extended time bloodstream effectively CD47 on cytomembrane colorectal cancer (CRC) cells. Notably, blocking enhances phagocytosis CRC cells by macrophages. Additionally, 3BP, inhibitor hexokinase II (HK 2 ), suppresses glycolysis, leading reduction adenosine triphosphate (ATP) levels lactate production. Besides, it promotes polarization tumor-associated macrophages (TAMs) towards anti-tumor M1 phenotype. Furthermore, integration MPB NPs-mediated therapy (PTT) therapeutic efficacy against tumors. These make attractive future development innovative approaches CRC. Concurrently, introduces universal approach engineering disease-tailored membranes tumor therapy.

Language: Английский

Conquering the Hypoxia Limitation for Photodynamic Therapy DOI

Yilin Wan,

Lian‐Hua Fu, Chunying Li

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(48)

Published: Sept. 27, 2021

Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, due the hypoxic nature characteristic of many solid tumors, PDT is frequently limited therapeutic effect. Moreover, consumption O2 during may further aggravate tumor condition, which promotes proliferation, metastasis, invasion resulting poor prognosis treatment. Therefore, numerous efforts have been made increase content with goal enhancing efficacy. Herein, these strategies developed past decade are comprehensively reviewed alleviate hypoxia, including 1) delivering exogenous directly, 2) generating situ, 3) reducing cellular by inhibiting respiration, 4) regulating TME, (e.g., normalizing vasculature or disrupting extracellular matrix), 5) hypoxia-inducible factor 1 (HIF-1) signaling pathway relieve hypoxia. Additionally, -independent Type-I also discussed as an alternative strategy. By reviewing progress, it hoped that this review will provide innovative perspectives new nanomaterials designed combat hypoxia avoid associated limitation PDT.

Language: Английский

Citations

469

Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies DOI
Jianlei Xie, Yingwei Wang, Wonseok Choi

et al.

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(16), P. 9152 - 9201

Published: Jan. 1, 2021

Photodynamic therapy (PDT) has been extensively investigated for decades tumor treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and immune activation ability.

Language: Английский

Citations

386

Aggregation-Induced Emission (AIE), Life and Health DOI Creative Commons
Haoran Wang, Qiyao Li, Parvej Alam

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405

Published: July 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Language: Английский

Citations

202

Nanotechnology for Boosting Cancer Immunotherapy and Remodeling Tumor Microenvironment: The Horizons in Cancer Treatment DOI
Shan Gao, Xiaoye Yang,

Jiangkang Xu

et al.

ACS Nano, Journal Year: 2021, Volume and Issue: 15(8), P. 12567 - 12603

Published: Aug. 2, 2021

Immunotherapy that harnesses the human immune system to fight cancer has received widespread attention and become a mainstream strategy for treatment. Cancer immunotherapy not only eliminates primary tumors but also treats metastasis recurrence, representing major advantage over traditional treatments. Recently with development of nanotechnology, there exists much work applying nanomaterials on basis their excellent physiochemical properties, such as efficient tissue-specific delivery function, huge specific surface area, controllable chemistry. Consequently, nanotechnology holds significant potential in improving efficacy immunotherapy. Nanotechnology-based mainly manifests its inhibitory effect via two different approaches: one is produce an effective anti-tumor response during tumorigenesis, other enhance tumor defense ability by modulating suppression mechanism microenvironment. With success immunotherapy, understanding interaction between smart nanomedicine provided vigorous vitality This review highlights application, progress, prospect process immunoediting discusses several engineering methods improve efficiency

Language: Английский

Citations

177

Recent advances on endogenous/exogenous stimuli-triggered nanoplatforms for enhanced chemodynamic therapy DOI
Qianqian Sun, Zhao Wang, Bin Liu

et al.

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 451, P. 214267 - 214267

Published: Nov. 6, 2021

Language: Английский

Citations

142

Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy DOI
Zhaoyou Chu, Juan Yang, Zheng Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 481, P. 215049 - 215049

Published: Feb. 9, 2023

Language: Английский

Citations

136

Recent advances in porphyrin-based MOFs for cancer therapy and diagnosis therapy DOI
Zhao Wang, Qianqian Sun, Bin Liu

et al.

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 439, P. 213945 - 213945

Published: April 24, 2021

Language: Английский

Citations

129

Tailoring Supramolecular Prodrug Nanoassemblies for Reactive Nitrogen Species-Potentiated Chemotherapy of Liver Cancer DOI
Yongyan Deng, Yupeng Wang, Fan Jia

et al.

ACS Nano, Journal Year: 2021, Volume and Issue: 15(5), P. 8663 - 8675

Published: April 30, 2021

The development of a controllable reactive nitrogen species (RNS) generation system for cancer treatment has remained elusive. Herein, supramolecular prodrug nanoassemblies (SPNA) strategy that co-delivers nitric oxide (NO) donor and superoxide anion (O2•–) inducing chemotherapeutic agent was reported RNS-potentiated chemotherapy. mole ratio platinum(IV) NO could be precisely tailored in SPNAPt/NO. Platinum(II) would released intracellularly to produce highly toxic RNS, peroxynitrite (ONOO–). levels glutathione reductase (GR) xeroderma pigmentosum group A (XPA) were down-regulated by ONOO–, thus synergistically decreasing detoxification blocking DNA damage repair Pt-based efficacy SPNAPt/NO validated on subcutaneous hepatoma xenograft models an orthotopic cisplatin-resistant model. This co-delivery O2•– agents RNS-mediated therapy provides insightful direction treatment.

Language: Английский

Citations

126

Ternary Alloy PtWMn as a Mn Nanoreservoir for High‐Field MRI Monitoring and Highly Selective Ferroptosis Therapy DOI
Guoqiang Guan, Cheng Zhang, Huiyi Liu

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(31)

Published: April 23, 2022

Ferroptosis exhibits potential to damage drug-resistant cancer cells. However, it is still restricted with the "off-target" toxicity from undesirable leakage of metal ions ferroptosis agents, and lack reliable imaging for monitoring process in living systems. Herein, we develop a novel ternary alloy PtWMn nanocube as Mn reservoir, further design microenvironment-triggered nanoplatform that can accurately release within tumor increase reactive oxygen species (ROS) generation, produce O2 consume excess glutathione synergistically enhancing nonferrous ferroptosis. Moreover, this exerts responsive signal high-field magnetic resonance (MRI), which enables real-time report initiation through changes T1-/T2-MRI. Thus, our provides strategy store, deliver precisely MRI-guided high-specificity therapy.

Language: Английский

Citations

82

Free radical as a double-edged sword in disease: Deriving strategic opportunities for nanotherapeutics DOI

Lin Zhu,

Meiying Luo, Yinfeng Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 475, P. 214875 - 214875

Published: Oct. 14, 2022

Language: Английский

Citations

74