Photo-Enhanced Chemotherapy Performance in Bladder Cancer Treatment via Albumin Coated AIE Aggregates DOI
Keke Ding, Lirong Wang,

Jiamiao Zhu

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 7535 - 7546

Published: April 12, 2022

The implementation of cisplatin-based neoadjuvant chemotherapy (NAC) plays a key role in conjunction with surgical resection preventing bladder cancer progression and recurrence. However, the significant dose-dependent toxic side effects NAC are still major challenge. To solve this problem, we developed photoenhanced (PECC) strategy based on AIEgen ((E)-3-(2-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)-1,1-dimethyl-1H-3λ4-benzo[e]indol-3-yl)propane-1-sulfonate), which is abbreviated as BITT. Multifunctional BITT@BSA–DSP nanoparticles (NPs) were employed an albumin-based nanocarrier decorated cisplatin(IV) prodrug loaded to produce strong near-infrared fluorescence imaging (NIR FLI), they exhibited good photoenhancement performance via photodynamic therapy (PDT) photothermal (PTT). In vitro results demonstrated that NPs could be efficiently taken up by cells reduced release Pt (II) under reductase, ensuring effect. Furthermore, both vivo evaluation verified integration NIR FL imaging-guided PECC promoted sensitivity cisplatin negligible effects. This work provides promising enhance multiple cancers drugs even achieve effective treatments for drug-resistant cancers.

Language: Английский

Cuproptosis: Harnessing Transition Metal for Cancer Therapy DOI
Wuyin Wang, Wentao Mo, Zishan Hang

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(20), P. 19581 - 19599

Published: Oct. 11, 2023

Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They act constituents of metalloenzymes involved cellular metabolism, function signaling molecules to regulate the proliferation metastasis tumors, are integral components metal-based anticancer drugs. Notably, recent research reveals that excessive copper can also modulate occurrence programmed cell death (PCD), known cuprotosis, cancer cells. This modulation occurs through disruption tumor metabolism induction proteotoxic stress. discovery uncovers a mode interaction between transition metals proteins, emphasizing intricate link homeostasis metabolism. Moreover, they provide innovative therapeutic strategies for precise diagnosis treatment malignant tumors. At crossroads chemistry oncology, we undertake comprehensive review elucidating molecular mechanisms underpinning cuproptosis. Additionally, summarize current nanotherapeutic approaches target cuproptosis an overview available laboratory clinical methods monitoring this process. In context emerging concepts, challenges, opportunities, emphasize significant potential nanotechnology advancement field.

Language: Английский

Citations

82
Glutathione Depletion‐Induced Activation of Dimersomes for Potentiating the Ferroptosis and Immunotherapy of “Cold” Tumor DOI
Zhanwei Zhou, Huan Liang, Ruoxi Yang

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(22)

Published: March 3, 2022

The abundant glutathione (GSH) in "cold" tumors weakens ferroptosis therapy and the immune response. Inspired by lipids, we fabricated cinnamaldehyde dimers (CDC) into lipid-like materials to form dimersomes capable of depleting GSH delivering therapeutics potentiate immunotherapy breast cancer. exhibited superior storage stability for over one year. After reaching tumor, they quickly underwent breakage cytosol owing conjugation hydrophilic on CDC Michael addition, which not only triggered drug release fluorescence switch "ON", but also led depletion intracellular GSH. Ferroptosis was significantly enhanced after combination with sorafenib (SRF) elicited a robust response vivo promoting maturation dendritic cells priming CD8+ T cells. As result, CDC@SRF cured cancer all mice four doses administration.

Language: Английский

Citations

80
Photo-enhanced upcycling H2O2 into hydroxyl radicals by IR780-embedded Fe3O4@MIL-100 for intense nanocatalytic tumor therapy DOI

Ju‐E Cun,

Yang Pan, Zhuangzhuang Zhang

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 287, P. 121687 - 121687

Published: July 19, 2022

Language: Английский

Citations

80
Glutathione‐Bioimprinted Nanoparticles Targeting of N6‐methyladenosine FTO Demethylase as a Strategy against Leukemic Stem Cells DOI
Kunxia Cao, Yangyang Du,

Xin Bao

et al.

Small, Journal Year: 2022, Volume and Issue: 18(13)

Published: Feb. 4, 2022

Abstract The N6‐methyladenosine (m 6 A) demethylase FTO plays an oncogenic role in acute myeloid leukemia (AML). Despite the promising recent progress for developing some small‐molecule inhibitors, clinical potential remains limited due to mild biological function, toxic side effects and low sensitivity and/or specificity leukemic stem cells (LSCs). Herein, inhibitor‐loaded GSH‐bioimprinted nanocomposites (GNPIPP12MA) are developed that achieves targeting of FTO/m A pathway synergized GSH depletion enhancing anti‐leukemogenesis. GNPIPP12MA can selectively target blasts, especially LSCs, induce ferroptosis by disrupting intracellular redox status. In addition, increases global m RNA modification decreases transcript levels LSCs. augments efficacy PD‐L1 blockade increasing infiltration cytotoxic T enhanced anti‐leukemia immunity. This study offers insights a nanoplatform methylation as synergistic treatment strategy against cancer may translate applications.

Language: Английский

Citations

71
GSH‐Activated Porphyrin Sonosensitizer Prodrug for Fluorescence Imaging‐Guided Cancer Sonodynamic Therapy DOI

Caiting Deng,

Meichen Zheng,

Shupeng Han

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(32)

Published: May 5, 2023

Sonodynamic therapy (SDT), which uses ultrasound to trigger a sonosensitizer generate reactive oxygen species (ROS), is promising form of cancer with outstanding tissue penetration depth. However, the may inevitably spread surrounding healthy beyond tumor, resulting in undesired side effects under an stimulus. Herein, as glutathione (GSH) overexpressed tumor microenvironment, GSH-activatable prodrug was designed by attaching quencher tetraphydroxy porphyrin for therapy. The exhibited poor fluorescence and low ROS generation capacity irradiation but it can be activated GSH simultaneously switch on emission site. Compared non-quenched sonosensitizer, significantly higher tumor/healthy organ ratios, due specific activation tumor. Finally, efficient growth inhibition irradiation, further demonstrating its promise GSH-activated highly effective treatment.

Language: Английский

Citations

55
Mesoporous silica/organosilica nanoparticles for cancer immunotherapy DOI Creative Commons
Shevanuja Theivendran, Sergei Lazarev, Chengzhong Yu

et al.

Exploration, Journal Year: 2023, Volume and Issue: 3(3)

Published: May 9, 2023

Cancer is one of the fatal diseases in history humankind. In this regard, cancer immunotherapeutic strategies have revolutionized traditional mode treatment. Silica based nano-platforms been extensively applied nanomedicine including immunotherapy. Mesoporous silica nanoparticles (MSN) and mesoporous organosilica (MON) are attractive candidates due to ease controlling structural parameters as needed for targeted applications. Especially, MON provide an additional advantage composition modulating biological functions actively synergize with other strategies. review, applications MSN, MON, metal-doped MSN/MON field immunotherapy tumor microenvironment regulation comprehensively summarized by highlighting compositional attributes silica-based nanoplatforms.

Language: Английский

Citations

49
Recent Development of Copper‐Based Nanozymes for Biomedical Applications DOI
Xin Yu, Yawen Wang, Jian Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 24, 2023

Copper (Cu), an indispensable trace element within the human body, serving as intrinsic constituent of numerous natural enzymes, carrying out vital biological functions. Furthermore, nanomaterials exhibiting enzyme-mimicking properties, commonly known nanozymes, possess distinct advantages over their enzyme counterparts, including cost-effectiveness, enhanced stability, and adjustable performance. These advantageous attributes have captivated attention researchers, inspiring them to devise various Cu-based nanomaterials, such copper oxide, Cu metal-organic framework, CuS, explore potential in enzymatic catalysis. This comprehensive review encapsulates most recent advancements illuminating applications realm biochemistry. Initially, it is delved into emulation typical types achieved by nanomaterials. Subsequently, latest breakthroughs concerning nanozymes biochemical sensing, bacterial inhibition, cancer therapy, neurodegenerative diseases treatment discussed. Within this segment, also explored modulation nanozyme activity. Finally, a visionary outlook for future development presented.

Language: Английский

Citations

42
The application of nanoparticles-based ferroptosis, pyroptosis and autophagy in cancer immunotherapy DOI Creative Commons

Wen Deng,

Haojie Shang,

Yonghua Tong

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 7, 2024

Abstract Immune checkpoint blockers (ICBs) have been applied for cancer therapy and achieved great success in the field of immunotherapy. Nevertheless, broad application ICBs is limited by low response rate. To address this issue, increasing studies found that induction immunogenic cell death (ICD) tumor cells becoming an emerging therapeutic strategy treatment, not only straightly killing but also enhancing dying immunogenicity activating antitumor immunity. ICD a generic term representing different modes containing ferroptosis, pyroptosis, autophagy apoptosis. Traditional chemotherapeutic agents usually inhibit growth based on apoptotic ICD, most are resistant to Thus, non-apoptotic considered be more efficient approach therapy. In addition, due ineffective localization inducers, various types nanomaterials being developed achieve targeted delivery improved immunotherapeutic efficiency. review, we briefly outline molecular mechanisms pyroptosis autophagy, as well their reciprocal interactions with immunity, then summarize current progress ICD-induced nanoparticles strategies illustrate applications Graphical

Language: Английский

Citations

23
Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy DOI Creative Commons
Nilmadhab Roy, Priyankar Paira

ACS Omega, Journal Year: 2024, Volume and Issue: 9(19), P. 20670 - 20701

Published: April 16, 2024

The cellular defense system against exogenous substances makes therapeutics inefficient as intracellular glutathione (GSH) exhibits an astounding antioxidant activity in scavenging reactive oxygen species (ROS) or nitrogen (RNS) other free radicals produced by the therapeutics. In cancer cell microenvironment, GSH level becomes exceptionally high to fight oxidative stress created production of ROS/RNS any radicals, which are byproducts redox reactions respiration processes. Thus, order maintain homeostasis for survival cells and their rapid proliferation, starts escalate. this circumstance, administration anticancer is vain, elevated reduces potential reduction they produce. Therefore, augment therapeutic agents condition, must be depleted hook crook. Hence, Review aims compile precisely role cells, importance its depletion therapy examples a few selected metal complexes able trigger death depleting level.

Language: Английский

Citations

16
Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy DOI

Wei Xu,

Guoqiang Guan, Renye Yue

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

Citations

4