Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy

Theranostics, Journal Year: 2022, Volume and Issue: 13(1), P. 295 - 323

Published: Dec. 19, 2022

Cancer remains a severe threat to human health. To date, although various therapeutic methods, including radiotherapy (RT), chemotherapy, chemodynamic therapy (CDT), phototherapy, starvation therapy, and immunotherapy, have entered new stage of rapid progress in cancer theranostics, their limited effect significant side effects need be considered carefully. With the development nanotechnology, marriage nanomaterials methods provides practical possibility improve deficiencies therapy. Notably, metal-organic frameworks (MOFs) composed ions/clusters bridging ligands through coordination bonds been widely applied deal with drawbacks different such as effects, low stability, poor efficacy, owing controllable morphologies, tailorable diameters, diverse compositions, tunable porosities, high specific surface areas, facile functionalization, good biocompatibility. This review summarizes recent advanced developments achievements multifunctional MOF-based nanoplatforms for single RT, CDT, phototherapy (photodynamic photothermal therapy), combination methods. Moreover, prospects challenges used tumor are also discussed.

Language: Английский

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Metal-organic framework nanoshell structures: Preparation and biomedical applications

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 490, P. 215211 - 215211

Published: May 12, 2023

Language: Английский

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Nanohybrid Double Network Hydrogels Based on a Platinum Nanozyme Composite for Antimicrobial and Diabetic Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(14), P. 17612 - 17626

Published: April 3, 2023

Along with hypoxia, severe bacterial infection, and abnormal pH, continuous inflammatory response hinders diabetic wounds from healing. It leads to the accumulation of large amounts reactive oxygen species (ROS) therefore prevents transition phase proliferative phase. In this work, a nanohybrid double network hydrogel injectable, self-healing, tissue adhesion properties based on platinum nanozyme composite (PFOB@PLGA@Pt) was constructed manage wound PFOB@PLGA@Pt exhibited supply capacity enzyme catalytic performance accompanied by pH self-regulation in entire phases first stage, carried perfluorooctyl bromide (PFOB) can ameliorate hypoxia boost glucose oxidase-like catalyzed reaction Pt NPs, leading lowered environment gluconic acid. As result, NADH oxidase-like, peroxidase-like, multiple activities were activated successively, synergistic antibacterial effects through production ROS. After infection had cleared, catalase-like superoxide dismutase-like NPs reshaped redox microenvironment scavenging excess ROS, which transitioned The microenvironmentally adaptive treatment cover all healing, showing significant promoting effect repair infected wounds.

Language: Английский

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A Strategy of Fenton Reaction Cycloacceleration for High‐Performance Ferroptosis Therapy Initiated by Tumor Microenvironment Remodeling

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(18)

Published: March 9, 2023

Abstract The emerging tumor ferroptosis therapy confronts impediments of the microenvironment (TME) with weak intrinsic acidity, inadequate endogenous H 2 O , and a powerful intracellular redox balance system that eliminates toxic reactive oxygen species (ROS). Herein, strategy Fenton reaction cycloacceleration initiated by remodeling TME for magnetic resonance imaging (MRI)‐guided high‐performance tumors is proposed. synthesized nanocomplex exhibits enhanced accumulation at carbonic anhydrase IX (CAIX)‐positive based on CAIX‐mediated active targeting, increased acidification via inhibition CAIX 4‐(2‐aminoethyl) benzene sulfonamide (ABS) (remodeling TME). This accumulated + abundant glutathione in synergistically trigger biodegradation to release loaded cuprous oxide nanodots (CON), β ‐lapachon (LAP), Fe 3+ gallic acid‐ferric ions coordination networks (GF). Fenton‐like reactions are cycloaccelerated catalytic loop Fe‐Cu, LAP‐triggered nicotinamide adenine dinucleotide phosphate quinone oxidoreductase1‐mediated cycle, generating robust ROS plenitudinous lipid peroxides cells. detached GF network has improved relaxivities response TME. Therefore, promising MRI‐guided tumors.

Language: Английский

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An Intelligent Cupreous Nanoplatform with Self-Supplied H₂O₂ and Cu²⁺/Cu⁺ Conversion to Boost Cuproptosis and Chemodynamic Combined Therapy

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(2), P. 815 - 828

Published: Jan. 11, 2024

Cuproptosis is a newly identified copper-dependent cell death and holds great promise for cancer therapy. However, transporting enough copper into cells challenge. Herein, an intelligent cupreous nanoplatform (denoted as CuO2-MSN@TA-Cu2+), consisting of in situ formation CuO2 within mesoporous silica nanoparticles (MSN) then deposition with tannic acid (TA)-Cu2+ complex, designed developed to realize on-demand delivery cuproptosis-based combination CuO2-MSN@TA-Cu2+ exhibits tumor microenvironment-triggered therapeutic activity, wherein the outer TA-Cu2+ complex readily disassembled release Cu2+ liberate internal produce H2O2. The overloaded can not only directly convert endogenous H2O2 self-supplied highly toxic hydroxyl radicals chemodynamic therapy (CDT) via Cu-based Fenton-like reaction but also undergo glutathione-mediated reduction Cu+ species induce potent cellular cuproptosis enhance CDT. experimental results indicate that produces remarkable cytotoxicity against significantly suppresses growth by 93.42% mice-bearing 4T1 breast tumors. This work provides new paradigm boost cuproptosis-related may inspire design advanced nanoplatforms.

Language: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

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Copper‐Based Bio‐Coordination Nanoparticle for Enhanced Pyroptosis‐Cuproptosis Cancer Immunotherapy through Redox Modulation and Glycolysis Inhibition

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Copper-based nanoparticles have garnered significant interest in cancer therapy due to their ability induce oxidative stress and cuproptosis cells. However, antitumor effectiveness is constrained by the dynamic redox balance metabolic shift between phosphorylation glycolysis. Here, a polydopamine-coated copper-α-ketoglutaric acid (α-KG) coordination polymer nanoparticle (CKPP) designed for combined pyroptosis-cuproptosis immunotherapy amplifying reactive oxygen species (ROS) production regulating cellular metabolism. The intracellular imbalance achieved through synergistic effects of α-KG-induced mitochondrial reprogramming, photothermally enhanced superoxide dismutase-like activity polydopamine, glutathione depletion copper ions. multifaceted modulation results substantial increase ROS levels, triggering subsequent pyroptosis Furthermore, α-KG shifts metabolism from glycolysis phosphorylation, thereby enhancing induced combination dyshomeostasis inhibition potent enhancement pyroptosis-cuproptosis-mediated therapy. In murine model colorectal cancer, CKPP exhibited remarkable anticancer effect, achieving tumor rate 96.3% complete eradication two out five cases. Overall, this bio-engineered metal-organic nanocomposite demonstrates potential treating immunotherapy.

Language: Английский

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An analytical review of the therapeutic application of recent trends in MIL-based delivery systems in cancer therapy

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(2)

Published: Jan. 16, 2025

Language: Английский

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Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

Biomaterials Science, Journal Year: 2022, Volume and Issue: 11(4), P. 1182 - 1214

Published: Dec. 20, 2022

A review of the recent progress ROS-upgrading nanosystems in oncotherapy is presented.

Language: Английский

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Copper-olsalazine metal-organic frameworks as a nanocatalyst and epigenetic modulator for efficient inhibition of colorectal cancer growth and metastasis

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 152, P. 495 - 506

Published: Sept. 8, 2022

Language: Английский

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