Journal of Hematology & Oncology,
Journal Year:
2021,
Volume and Issue:
14(1)
Published: Oct. 7, 2021
Abstract
In
this
era
of
precision
medicine,
with
the
help
biomarkers,
immunotherapy
has
significantly
improved
prognosis
many
patients
malignant
tumor.
Deficient
mismatch
repair
(dMMR)/microsatellite
instability
(MSI)
status
is
used
as
a
biomarker
in
clinical
practice
to
predict
favorable
response
and
prognosis.
MSI
an
important
characteristic
which
facilitates
mutation
improves
likelihood
immunotherapy.
However,
dMMR/MSI
still
respond
poorly
immunotherapies,
partly
results
from
intratumor
heterogeneity
propelled
by
dMMR/MSI.
review,
we
discuss
how
mutations
tumor
cells
generates
heterogeneity,
especially
through
type
II
interferon
(IFN-γ)
signaling
tumor-infiltrating
lymphocytes
(TILs).
We
mechanism
perspective
dMMR/MSI,
molecular
pathways
TILs,
hinders
therapeutic
effect
Finally,
summarize
present
techniques
strategies
look
at
whole
design
personalized
regimes
achieve
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(33)
Published: March 7, 2023
Abstract
Immunotherapy
has
made
remarkable
strides
in
cancer
therapy
over
the
past
decade.
However,
such
emerging
still
suffers
from
low
response
rates
and
immune‐related
adverse
events.
Various
strategies
have
been
developed
to
overcome
these
serious
challenges.
Therein,
sonodynamic
(SDT),
as
a
non‐invasive
treatment,
received
ever‐increasing
attention
especially
treatment
of
deep‐seated
tumors.
Significantly,
SDT
can
effectively
induce
immunogenic
cell
death
trigger
systemic
anti‐tumor
immune
response,
termed
immunotherapy.
The
rapid
development
nanotechnology
revolutionized
effects
with
robust
induction.
As
result,
more
innovative
nanosonosensitizers
synergistic
modalities
are
established
superior
efficacy
safe
profile.
In
this
review,
recent
advances
immunotherapy
summarized
particular
emphasis
on
how
be
explored
harness
for
amplifying
response.
Moreover,
current
challenges
field
prospects
its
clinical
translation
also
presented.
It
is
anticipated
that
review
provide
rational
guidance
facilitate
nanomaterials‐assisted
immunotherapy,
helping
pave
way
next‐generation
eventually
achieve
durable
patients.
Bone Research,
Journal Year:
2023,
Volume and Issue:
11(1)
Published: Feb. 27, 2023
Osteosarcoma,
with
poor
survival
after
metastasis,
is
considered
the
most
common
primary
bone
cancer
in
adolescents.
Notwithstanding
efforts
of
researchers,
its
five-year
rate
has
only
shown
limited
improvement,
suggesting
that
existing
therapeutic
strategies
are
insufficient
to
meet
clinical
needs.
Notably,
immunotherapy
certain
advantages
over
traditional
tumor
treatments
inhibiting
metastasis.
Therefore,
managing
immune
microenvironment
osteosarcoma
can
provide
novel
and
valuable
insight
into
multifaceted
mechanisms
underlying
heterogeneity
progression
disease.
Additionally,
given
advances
nanomedicine,
there
exist
many
advanced
nanoplatforms
for
enhanced
satisfactory
physiochemical
characteristics.
Here,
we
review
classification,
characteristics,
functions
key
components
osteosarcoma.
This
also
emphasizes
application,
progress,
prospects
discusses
several
nanomedicine-based
options
enhance
efficiency
treatment.
Furthermore,
examine
disadvantages
standard
present
future
perspectives
immunotherapy.
Coordination Chemistry Reviews,
Journal Year:
2023,
Volume and Issue:
484, P. 215098 - 215098
Published: March 14, 2023
Non-invasive
tumor
therapy
via
in
situ
ROS
generation
is
emerging
as
an
appealing
treatment
modality
with
the
potential
for
deep-seated
tumors
without
side
effects
on
healthy
tissue.
Chemodynamic
(CDT)
based
Fenton/Fenton-like
reactions
a
non-invasive
cancer
treatment,
which
converts
hydrogen
peroxide
(H2O2)
found
locally
into
lethal
hydroxyl
radicals
(OH)
through
exploitation
of
transition
metal
ions
catalysts
acidic
microenvironment
(TME)
suitable
effective
oncotherapy.
Metal-organic
frameworks
(MOFs)
exhibit
great
promise
CDT
account
their
unique
properties.
Among
them,
stimuli-responsive
nature
and
porosity
MOFs
make
them
ideal
TME-targeted
cargo
delivery.
In
addition,
ability
to
select
appropriate
organic
ligands
makes
it
possible
prepare
intrinsic
antitumor
activity.
This
review
primarily
summarizes
latest
progress
application
microenvironment-oriented
CDT,
including
or
chemodynamic
Furthermore,
remaining
challenges
suggestions
future
applications
are
also
presented.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: May 14, 2022
Immunotherapeutic
interventions
represent
a
promising
approach
to
treating
cancer,
with
strategies
such
as
immune
checkpoint
blockade
(ICB),
immunogenic
sonodynamic
therapy
(SDT),
and
adjuvant
T
cell
delivery
having
exhibited
clinical
promise.
In
this
report,
we
describe
the
use
of
cancer
membrane-coated
triphenylphosphonium
(TPP)
decorated
nano-metal-organic
framework
(nMOF)
constructs
[Zr-TCPP(TPP)/R837@M]
that
were
used
generate
homologous,
mitochondria-targeted
platforms
high
rate
sonosensitizer
loading.
This
construct
was
utilized
simultaneously
promote
tumor
antigen
presentation
via
enhancing
SDT
while
synergistically
promoting
dendritic
(DC)
maturation
through
Toll-like
receptor
agonist
R837.
vitro,
these
functionalized
nMOFs
readily
internalized
by
homologous
cells
in
which
they
efficiently
targeted
mitochondria,
DC
activation
induction
death
(ICD)
following
ultrasound
exposure.
Moreover,
nanoplatform
able
achieve
vivo
synergy
anti-CTLA-4
ICB
reverse
immunosuppression
microenvironment
(TME),
thus
achieving
more
robust
antitumor
efficacy
capable
suppressing
metastatic
disease
progression
facilitating
development
durable
memory
responses.
Together,
results
highlight
enhanced
activity
overcoming
an
immunosuppressive
TME,
thereby
immunity.
Cancer and Metastasis Reviews,
Journal Year:
2023,
Volume and Issue:
42(3), P. 601 - 627
Published: Feb. 24, 2023
Every
sixth
person
in
the
world
dies
due
to
cancer,
making
it
second
leading
severe
cause
of
death
after
cardiovascular
diseases.
According
WHO,
cancer
claimed
nearly
10
million
deaths
2020.
The
most
common
types
cancers
reported
have
been
breast
(lung,
colon
and
rectum,
prostate
cases),
skin
(non-melanoma)
stomach.
In
addition
surgery,
widely
used
traditional
anti-cancer
treatment
are
radio-
chemotherapy.
However,
these
do
not
distinguish
between
normal
malignant
cells.
Additional
methods
evolved
over
time
for
early
detection
targeted
therapy
cancer.
each
method
has
its
limitations
associated
costs
quite
high
with
adverse
effects
on
quality
life
patients.
Use
individual
atoms
or
a
cluster
(nanoparticles)
can
paradigm
shift
by
virtue
providing
point
sight
sensing
diagnosis
Nanoparticles
(1-100
nm
size)
1000
times
smaller
size
than
human
cell
endowed
safer
relocation
capability
attack
mechanically
chemically
at
precise
location
which
is
one
avenue
that
be
destroy
cells
precisely.
This
review
summarises
extant
understanding
work
done
this
area
pave
way
physicians
accelerate
use
hybrid
mode
treatments
leveraging
various
nanoparticles.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(23), P. 23889 - 23902
Published: Nov. 25, 2023
Development
of
a
nanoscale
drug
delivery
system
that
can
simultaneously
exert
efficient
tumor
therapeutic
efficacy
while
creating
the
desired
antitumor
immune
responses
is
still
challenging.
Herein,
we
report
use
manganese
dioxide
(MnO2)-entrapping
dendrimer
nanocarrier
to
codeliver
glucose
oxidase
(GOx)
and
cyclic
GMP-AMP
(cGAMP),
an
agonist
stimulator
interferon
genes
(STING)
for
improved
chemodynamic/starvation/immune
therapy.
Methoxy
poly(ethylene
glycol)
(mPEG)-
phenylboronic
acid
(PBA)-modified
generation
5
(G5)
poly(amidoamine)
dendrimers
were
first
synthesized
then
entrapped
with
MnO2
nanoparticles
(NPs)
generate
hybrid
MnO2@G5-mPEG–PBA
(MGPP)
NPs.
The
created
MGPP
NPs
core
size
2.8
nm
display
glutathione
depletion
ability,
favorable
Mn2+
release
profile
under
microenvironment
mimetic
condition
enable
Fenton-like
reaction
T1-weighted
magnetic
resonance
(MR)
imaging.
We
show
MGPP-mediated
GOx
facilitates
enhanced
chemodynamic/starvation
therapy
cancer
cells
in
vitro,
further
codelivery
cGAMP
effectively
trigger
immunogenic
cell
death
(ICD)
strongly
promote
maturation
dendritic
cells.
In
bilateral
mouse
colorectal
model,
nanosystem
elicits
potent
performance
strong
abscopal
effect,
greatly
improving
overall
survival
rate.
Importantly,
dendrimer-mediated
not
only
allows
coordination
respective
chemodynamic/starvation-triggered
ICD
augmented
STING
activation
boost
systemic
responses,
but
also
enables
MR
imaging,
potentially
serving
as
promising
nanoplatform
responses.