Intratumor heterogeneity: the hidden barrier to immunotherapy against MSI tumors from the perspective of IFN-γ signaling and tumor-infiltrating lymphocytes DOI Creative Commons

Wantao Wu,

Yihan Liu, Shan Zeng

et al.

Journal of Hematology & Oncology, Journal Year: 2021, Volume and Issue: 14(1)

Published: Oct. 7, 2021

Abstract In this era of precision medicine, with the help biomarkers, immunotherapy has significantly improved prognosis many patients malignant tumor. Deficient mismatch repair (dMMR)/microsatellite instability (MSI) status is used as a biomarker in clinical practice to predict favorable response and prognosis. MSI an important characteristic which facilitates mutation improves likelihood immunotherapy. However, dMMR/MSI still respond poorly immunotherapies, partly results from intratumor heterogeneity propelled by dMMR/MSI. review, we discuss how mutations tumor cells generates heterogeneity, especially through type II interferon (IFN-γ) signaling tumor-infiltrating lymphocytes (TILs). We mechanism perspective dMMR/MSI, molecular pathways TILs, hinders therapeutic effect Finally, summarize present techniques strategies look at whole design personalized regimes achieve

Language: Английский

Carbon-based nanozymes: Design, catalytic mechanism, and bioapplication DOI
Yun Sun, Bolong Xu, Xueting Pan

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 475, P. 214896 - 214896

Published: Oct. 27, 2022

Language: Английский

Citations

155
Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy DOI
Shuang Liang, Jianjun Yao, Dan Liu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: March 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Language: Английский

Citations

142
A Noble AuPtAg‐GOx Nanozyme for Synergistic Tumor Immunotherapy Induced by Starvation Therapy‐Augmented Mild Photothermal Therapy DOI Creative Commons
Man Wang, Mengyu Chang, Pan Zheng

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(31)

Published: Sept. 25, 2022

Abstract Notwithstanding immune checkpoint blocking (ICB) therapy has made eminent clinical breakthroughs, overcoming immunologically “cold” tumors remains challenging. Here, a cascade potentiated nanomodulator AuPtAg‐GOx is engineered for boosting responsiveness. Upon 1064 nm laser irradiation, AuPtAg‐mediated mild photothermal (PTT) activates cytotoxic T lymphocytes and reverses the immunogenic tumor microenvironment. Further, to amplify thermal sensitivity of cells, glucose oxidase (GOx) introduced suppress production heat shock proteins, thereby promoting therapy. Complementarily, AuPtAg nanozymes with catalase‐like activity can ameliorate hypoxia, significantly improving GOx activity. As result, combination self‐augmented ability PD‐L1 antibody further escalate antitumor efficacy. The AuPtAg‐GOx‐based synergistic starvation therapy, PTT, immunotherapy enhancement strategy be favorable tool effectively kill cancer cells.

Language: Английский

Citations

116
Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment DOI Creative Commons
Hailong Tian,

Jiangjun Cao,

Bowen Li

et al.

Bone Research, Journal Year: 2023, Volume and Issue: 11(1)

Published: Feb. 27, 2023

Osteosarcoma, with poor survival after metastasis, is considered the most common primary bone cancer in adolescents. Notwithstanding efforts of researchers, its five-year rate has only shown limited improvement, suggesting that existing therapeutic strategies are insufficient to meet clinical needs. Notably, immunotherapy certain advantages over traditional tumor treatments inhibiting metastasis. Therefore, managing immune microenvironment osteosarcoma can provide novel and valuable insight into multifaceted mechanisms underlying heterogeneity progression disease. Additionally, given advances nanomedicine, there exist many advanced nanoplatforms for enhanced satisfactory physiochemical characteristics. Here, we review classification, characteristics, functions key components osteosarcoma. This also emphasizes application, progress, prospects discusses several nanomedicine-based options enhance efficiency treatment. Furthermore, examine disadvantages standard present future perspectives immunotherapy.

Language: Английский

Citations

112
Tumor microenvironment-oriented MOFs for chemodynamic therapy DOI Creative Commons

Xiaojiao Di,

Zhichao Pei, Yuxin Pei

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 484, P. 215098 - 215098

Published: March 14, 2023

Non-invasive tumor therapy via in situ ROS generation is emerging as an appealing treatment modality with the potential for deep-seated tumors without side effects on healthy tissue. Chemodynamic (CDT) based Fenton/Fenton-like reactions a non-invasive cancer treatment, which converts hydrogen peroxide (H2O2) found locally into lethal hydroxyl radicals (OH) through exploitation of transition metal ions catalysts acidic microenvironment (TME) suitable effective oncotherapy. Metal-organic frameworks (MOFs) exhibit great promise CDT account their unique properties. Among them, stimuli-responsive nature and porosity MOFs make them ideal TME-targeted cargo delivery. In addition, ability to select appropriate organic ligands makes it possible prepare intrinsic antitumor activity. This review primarily summarizes latest progress application microenvironment-oriented CDT, including or chemodynamic Furthermore, remaining challenges suggestions future applications are also presented.

Language: Английский

Citations

83
Enhancement of antitumor immunotherapy using mitochondria-targeted cancer cell membrane-biomimetic MOF-mediated sonodynamic therapy and checkpoint blockade immunotherapy DOI Creative Commons
Jiali Luo, Handong Wang, Zhan Shi

et al.

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: May 14, 2022

Immunotherapeutic interventions represent a promising approach to treating cancer, with strategies such as immune checkpoint blockade (ICB), immunogenic sonodynamic therapy (SDT), and adjuvant T cell delivery having exhibited clinical promise. In this report, we describe the use of cancer membrane-coated triphenylphosphonium (TPP) decorated nano-metal-organic framework (nMOF) constructs [Zr-TCPP(TPP)/R837@M] that were used generate homologous, mitochondria-targeted platforms high rate sonosensitizer loading. This construct was utilized simultaneously promote tumor antigen presentation via enhancing SDT while synergistically promoting dendritic (DC) maturation through Toll-like receptor agonist R837. vitro, these functionalized nMOFs readily internalized by homologous cells in which they efficiently targeted mitochondria, DC activation induction death (ICD) following ultrasound exposure. Moreover, nanoplatform able achieve vivo synergy anti-CTLA-4 ICB reverse immunosuppression microenvironment (TME), thus achieving more robust antitumor efficacy capable suppressing metastatic disease progression facilitating development durable memory responses. Together, results highlight enhanced activity overcoming an immunosuppressive TME, thereby immunity.

Language: Английский

Citations

76
Gold nanoparticles in microelectronics advancements and biomedical applications DOI

Mohamed Mohamady Ghobashy,

Sh. A Alkhursani,

Haifa A. Alqahtani

et al.

Materials Science and Engineering B, Journal Year: 2024, Volume and Issue: 301, P. 117191 - 117191

Published: Jan. 13, 2024

Language: Английский

Citations

64
Nanoparticle-mediated cancer cell therapy: basic science to clinical applications DOI Creative Commons
Jaya Verma, Caaisha Warsame, Rajkumar Kottayasamy Seenivasagam

et al.

Cancer and Metastasis Reviews, Journal Year: 2023, Volume and Issue: 42(3), P. 601 - 627

Published: Feb. 24, 2023

Every sixth person in the world dies due to cancer, making it second leading severe cause of death after cardiovascular diseases. According WHO, cancer claimed nearly 10 million deaths 2020. The most common types cancers reported have been breast (lung, colon and rectum, prostate cases), skin (non-melanoma) stomach. In addition surgery, widely used traditional anti-cancer treatment are radio- chemotherapy. However, these do not distinguish between normal malignant cells. Additional methods evolved over time for early detection targeted therapy cancer. each method has its limitations associated costs quite high with adverse effects on quality life patients. Use individual atoms or a cluster (nanoparticles) can paradigm shift by virtue providing point sight sensing diagnosis Nanoparticles (1-100 nm size) 1000 times smaller size than human cell endowed safer relocation capability attack mechanically chemically at precise location which is one avenue that be destroy cells precisely. This review summarises extant understanding work done this area pave way physicians accelerate use hybrid mode treatments leveraging various nanoparticles.

Language: Английский

Citations

59
Unleashing the power of porphyrin photosensitizers: Illuminating breakthroughs in photodynamic therapy DOI
Alibasha Akbar, Syamantak Khan, Tanmay Chatterjee

et al.

Journal of Photochemistry and Photobiology B Biology, Journal Year: 2023, Volume and Issue: 248, P. 112796 - 112796

Published: Oct. 4, 2023

Language: Английский

Citations

47
Manganese Dioxide-Entrapping Dendrimers Co-Deliver Protein and Nucleotide for Magnetic Resonance Imaging-Guided Chemodynamic/Starvation/Immune Therapy of Tumors DOI
Yue Gao,

Zhijun Ouyang,

Siyan Shen

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(23), P. 23889 - 23902

Published: Nov. 25, 2023

Development of a nanoscale drug delivery system that can simultaneously exert efficient tumor therapeutic efficacy while creating the desired antitumor immune responses is still challenging. Herein, we report use manganese dioxide (MnO2)-entrapping dendrimer nanocarrier to codeliver glucose oxidase (GOx) and cyclic GMP-AMP (cGAMP), an agonist stimulator interferon genes (STING) for improved chemodynamic/starvation/immune therapy. Methoxy poly(ethylene glycol) (mPEG)- phenylboronic acid (PBA)-modified generation 5 (G5) poly(amidoamine) dendrimers were first synthesized then entrapped with MnO2 nanoparticles (NPs) generate hybrid MnO2@G5-mPEG–PBA (MGPP) NPs. The created MGPP NPs core size 2.8 nm display glutathione depletion ability, favorable Mn2+ release profile under microenvironment mimetic condition enable Fenton-like reaction T1-weighted magnetic resonance (MR) imaging. We show MGPP-mediated GOx facilitates enhanced chemodynamic/starvation therapy cancer cells in vitro, further codelivery cGAMP effectively trigger immunogenic cell death (ICD) strongly promote maturation dendritic cells. In bilateral mouse colorectal model, nanosystem elicits potent performance strong abscopal effect, greatly improving overall survival rate. Importantly, dendrimer-mediated not only allows coordination respective chemodynamic/starvation-triggered ICD augmented STING activation boost systemic responses, but also enables MR imaging, potentially serving as promising nanoplatform responses.

Language: Английский

Citations

45