ACS Biomaterials Science & Engineering,
Journal Year:
2023,
Volume and Issue:
9(9), P. 5205 - 5221
Published: Aug. 14, 2023
Glioblastoma
(GBM)
is
an
aggressive
type
of
cancer
that
has
led
to
the
death
a
large
population.
The
traditional
approach
fails
develop
solution
for
GBM's
suffering
life.
Extensive
research
into
tumor
microenvironments
(TME)
indicates
TME
extracellular
vesicles
(EVs)
play
vital
role
in
development
and
progression.
EVs
are
classified
microvacuoles,
apoptotic
bodies,
exosomes.
Exosomes
most
highlighted
domains
research.
GBM
cell-derived
exosomes
participate
multiple
progression
events
such
as
immune
suppression,
angiogenesis,
premetastatic
niche
formation
(PMN),
ECM
(extracellular
matrix),
EMT
(epithelial-to-mesenchymal
transition),
metastasis,
stem
cell
therapeutic
drug
resistance.
also
carry
signature
glioblastoma-related
status.
exosome-based
examination
part
new
generation
liquid
biopsy.
It
solved
early
diagnostic
limitations
GBM.
Traditional
approaches
do
not
cross
blood–brain
barrier
(BBB).
game
changer
treatment
it
emerging
potential
platform
effective,
efficient,
specific
development.
In
this
review,
we
have
explored
exosome–GBM
interlink,
clinical
impact
on
biomarkers,
therapeutics
GBM,
challenges,
future
directions
Therefore,
GBM-derived
offer
unique
opportunities,
which
currently
under
preclinical
testing.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(17)
Published: Jan. 30, 2023
Abstract
Polymerase
chain
reaction
(PCR)‐based
nucleic
acid
testing
has
played
a
critical
role
in
disease
diagnostics,
pathogen
surveillance,
and
many
more.
However,
this
method
requires
long
turnaround
time,
expensive
equipment,
trained
personnel,
limiting
its
widespread
availability
diagnostic
capacity.
On
the
other
hand,
clustered
regularly
interspaced
short
palindromic
repeats
(CRISPR)
technology
recently
demonstrated
capability
for
detection
with
high
sensitivity
specificity.
CRISPR‐mediated
biosensing
holds
great
promise
revolutionizing
procedures
developing
point‐of‐care
diagnostics.
This
review
focuses
on
recent
developments
both
fundamental
CRISPR
biochemistry
CRISPR‐based
techniques.
Four
ongoing
research
hotspots
molecular
diagnostics‐target
preamplification‐free
detection,
microRNA
(miRNA)
testing,
non‐nucleic‐acid
SARS‐CoV‐2
detection‐are
also
covered.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(14), P. 9784 - 9797
Published: March 12, 2024
Extracellular
vesicles
(EVs)
secreted
by
all
cell
types
are
involved
in
the
cell-to-cell
transfer
of
regulatory
factors
that
influence
and
tissue
phenotypes
normal
diseased
tissues.
EVs
thus
a
rich
source
biomarker
targets
for
assays
analyze
blood
urinary
disease
diagnosis.
Sensitive
detection
derived
from
specific
populations
is
key
major
hurdle
when
analyzing
complex
biological
samples,
but
innovative
approaches
surveyed
this
Perspective
can
streamline
EV
isolation
enhance
sensitivity
procedures
required
clinical
application
EV-based
diagnostics
therapeutics,
including
nanotechnology
microfluidics,
to
achieve
characterizations.
Finally,
also
outlines
opportunities
challenges
remaining
translation
assays.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(9), P. 2236 - 2252
Published: Jan. 1, 2024
Plant-derived
exosomes
(PDEs)
show
promising
potential
to
be
developed
as
a
therapeutic
agent
against
cancer,
owing
their
multiple
advantages
such
low
toxicity,
biocompatibility,
availability,
affordability,
etc.
The Journal of Liquid Biopsy,
Journal Year:
2024,
Volume and Issue:
3, P. 100138 - 100138
Published: Jan. 4, 2024
Extracellular
vesicles
(EVs)
are
the
cell's
secreted
component.
It
is
majorly
classified
into
microvesicles,
apoptotic
bodies,
and
exosomes.
Exosomes
play
a
significant
role
in
cancer
development
progression.
Its
molecular
signature
(DNA,
RNA,
Proteins,
lipids)
has
more
priority
profiling
current
decade.
In
prevention,
most
challenging
part
early
detection.
EVs-based
screening
develops
promising
platform.
Multi-Omics
exosomes
profiling-based
liquid
biopsy
support
detection
efficient
way.
This
approach
provides
detailed
expression
data
(it
may
be
inner
cargos
or
surface
express
molecules).
article
highlited
multi-omic
exosome
theranostics
applications
cancer,
technical
challenges,
improvisation
for
future
improvement.
Journal of Cellular and Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
27(11), P. 1603 - 1607
Published: May 15, 2023
This
short
communication
will
enlighten
the
readers
about
exosome
and
epithelial-mesenchymal
transition
(EMT)
related
to
several
complicated
events.
It
also
highlighted
therapeutic
potential
of
exosomes
against
EMT.
Exosome
toxicology,
heterogeneity,
a
single
profiling
approach
are
covered
in
this
article.
In
future,
could
help
us
get
closer
cancer
vaccine
precision
oncology.
ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(7), P. 2576 - 2590
Published: June 14, 2023
Cancer
is
a
complex
deadly
disease
that
has
caused
global
health
crisis
in
recent
epochs.
Colorectal
cancer
(CRC)
the
third
most
common
malignant
gastrointestinal
disease.
It
led
to
high
mortality
due
early
diagnostic
failure.
Extracellular
vesicles
(EVs)
come
with
promising
solutions
for
CRC.
Exosomes
(a
subpopulation
of
EVs)
play
vital
role
as
signaling
molecules
CRC
tumor
microenvironment.
secreted
from
all
active
cells.
Exosome-based
molecular
transport
(DNA,
RNA,
proteins,
lipids,
etc.)
transforms
recipient
cell's
nature.
In
CRC,
cell-derived
exosomes
(TEXs)
regulate
multiple
events
development
and
progression
such
immunogenic
suppression,
angiogenesis,
epithelial–mesenchymal
transitions
(EMT),
physical
changes
extracellular
matrix
(ECM),
metastasis.
Biofluid-circulated
tumor-derived
are
potential
tool
liquid
biopsy.
colorectal
detection
creates
great
impact
biomarker
research.
The
exosome-associated
theranostics
approach
state-of-the-art
method.
this
review,
we
address
associated
progression,
on
screening
(diagnostic
prognostic
biomarkers),
also
highlight
several
clinical
trials,
well
future
directions
exosome-based
Hopefully,
it
will
encourage
researchers
develop
theranostic
fight
The Journal of Liquid Biopsy,
Journal Year:
2023,
Volume and Issue:
2, P. 100129 - 100129
Published: Nov. 26, 2023
Cancer
is
an
unsolved
health
crisis
worldwide.
Extracellular
vesicles
(EVs)
address
this
problem
in
a
new
way.
In
cancer,
early
detection
highly
challenging,
exosomes
(a
subpopulation
of
EVs,
originating
from
endosomes)
overcome
limitation.
tumor-derived
(TEXs)
play
role
as
signaling
molecules
cancer
development
and
progression.
TEXs
required
more
detailed
investigation
for
specific
biomarkers
research.
Exosome
heterogeneity
(some
the
facts
regulate
it
such
exosome
size,
origin,
inner
molecular
diversity)
made
complication
liquid
biopsy.
Single
profiling
barcoding
support
overcoming
limitation
developing
precision
oncology.
interdisciplinary
approach
screening
specifically.
Clinical and Translational Discovery,
Journal Year:
2023,
Volume and Issue:
3(3)
Published: May 26, 2023
Abstract
Extracellular
vesicles
(EVs)
are
an
innovative
orientation
of
next‐generation
cancer
medicine.
In
EVs,
the
exosome
is
most
exciting
domain
associated
with
research
current
decade.Exosomes
have
both
progression
related
and
healing
capabilities
depending
on
source.
It
develops
a
new
platform
for
personalized
precision
medicine
visionary
project
to
come
reality.
