MXenes Antibacterial Properties and Applications: A Review and Perspective

Small, Journal Year: 2023, Volume and Issue: 19(14)

Published: Jan. 5, 2023

The mutations of bacteria due to the excessive use antibiotics, and generation antibiotic-resistant have made development new antibacterial compounds a necessity. MXenes emerged as biocompatible transition metal carbide structures with extensive biomedical applications. This is related MXenes' unique combination properties, including multifarious elemental compositions, 2D-layered structure, large surface area, abundant terminations, excellent photothermal photoelectronic properties. focus this review application MXenes, which has attracted attention researchers since 2016. A quick overview synthesis strategies provided then summarizes effect various factors (including structural optical charges, flake size, dispersibility) on biocidal activity MXenes. main mechanisms for deactivating by are discussed in detail rupturing bacterial membrane sharp edges nanoflakes, generating reactive oxygen species (ROS), bacteria. Hybridization other organic inorganic materials can result improved activities different applications such wound dressings water purification. Finally, challenges perspectives MXene nanomaterials agents presented.

Language: Английский

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Combined photothermal and sonodynamic therapy using a 2D black phosphorus nanosheets loaded coating for efficient bacterial inhibition and bone-implant integration

Biomaterials, Journal Year: 2023, Volume and Issue: 297, P. 122122 - 122122

Published: April 11, 2023

Language: Английский

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MXenes-based nanomaterials for biosensing and biomedicine

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 479, P. 215002 - 215002

Published: Jan. 10, 2023

Language: Английский

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Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet‐Based Sonosensitizers Via Crystalline‐to‐Amorphous Phase Transformation

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(17)

Published: Feb. 13, 2023

Abstract Sonodynamic therapy (SDT) has been a promising therapeutic modality for cancer because of its superior advantages compared with other strategies. However, the current sonosensitizers used SDT normally exhibit low activity ultrasound (US)‐induced reactive oxygen species (ROS) generation. Herein, crystalline‐to‐amorphous phase transformation is reported as simple but powerful strategy to engineer ultrathin 2D CoW‐LDH and NiW‐LDH nanosheets highly efficient SDT. The from polycrystalline amorphous ones achieved through acid etching treatment. Importantly, one, (a‐CoW‐LDH) possess higher ROS generation under US irradiation, which ≈17 times commercial TiO 2 sonosensitizer. results suggest that enhanced performance a‐CoW‐LDH US‐induced may be attributed transformation‐induced defect electronic structure changes. After polyethylene glycol modification, can serve high‐efficiency sonosensitizer achieve cell death in vitro tumor eradication vivo irradiation.

Language: Английский

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Stimuli responsive nanosonosensitizers for sonodynamic therapy

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 361, P. 547 - 567

Published: Aug. 15, 2023

Language: Английский

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Covalent Organic Framework Nanobowls as Activatable Nanosensitizers for Tumor‐Specific and Ferroptosis‐Augmented Sonodynamic Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(6)

Published: Jan. 3, 2023

Abstract Covalent organic frameworks (COFs) have attracted increasing attention for biomedical applications. COFs‐based nanosensitizers with uniform nanoscale morphology and tumor‐specific curative effects are in high demand; however, their synthesis is yet challenging. In this study, distinct COF nanobowls synthesized a controlled manner engineered as activatable sonodynamic activity. High crystallinity ensures an ordered porous structure of the efficient loading small‐molecule sonosensitizer rose bengal (RB). To circumvent non‐specific damage to normal tissues, sonosensitization effect specifically inhibited by situ growth manganese oxide (MnO x ) on RB‐loaded COFs. Upon reaction tumor‐overexpressed glutathione (GSH), “gatekeeper” MnO rapidly decomposed recover reactive oxygen species (ROS) generation capability under ultrasound irradiation. Increased intracellular ROS stress GSH consumption concomitantly induce ferroptosis improve efficacy. Additionally, unconventional bowl‐shaped renders enhanced tumor accumulation retention. The combination therapy achieves efficacy killing cancer cells inhibiting growth. This study paves way development morphologies biomedicine, offering paradigm realize ferroptosis‐augmented therapy.

Language: Английский

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Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions

Theranostics, Journal Year: 2023, Volume and Issue: 13(6), P. 1974 - 2014

Published: Jan. 1, 2023

Chemodynamic therapy (CDT) is well-known for using the tumor microenvironment to activate Fenton reaction or Fenton-like generate strong oxidative hydroxyl radicals tumor-specific treatment. It highly selective and safe, without depth limitation of tissue penetration, shows its potential as a new green therapeutic method with great clinical application. However, catalytic efficiency reagents involved in severely affected by inherent microenvironmental limitations tumors strict reaction-dependent conditions. With increasing application nanotechnology medical field, combined therapies based on different types functional nanomaterials have opened up avenues development next-generation CDT-enhanced system. This review will comprehensively exemplify representative results CDT other antitumor such chemotherapy, phototherapy, sonodynamic therapy, radiation magnetic hyperthermia immunotherapy, starvation gas gene oncosis combination thereof improving from hundreds latest literature, introduce strategies ingenious design nanomedicines regulations enhance further summarize challenges future perspective CDT-based multimodal anticancer therapy.

Language: Английский

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Single Atom‐Doped Nanosonosensitizers for Mutually Optimized Sono/Chemo‐Nanodynamic Therapy of Triple Negative Breast Cancer

Advanced Science, Journal Year: 2023, Volume and Issue: 10(6)

Published: Jan. 16, 2023

Sonodynamic therapy (SDT) represents a promising therapeutic modality for treating breast cancer, which relies on the generation of abundant reactive oxygen species (ROS) to induce oxidative stress damage. However, mutant cancers, especially triple-negative cancer (TNBC), have evolved acquire specific antioxidant defense functions, significantly limiting killing efficiency SDT. Herein, authors engineered distinct single copper atom-doped titanium dioxide (Cu/TiO2 ) nanosonosensitizer with highly catalytic and sonosensitive activities synergistic chemodynamic sonodynamic treatment TNBC. The single-atom Cu is anchored most stable Ti vacancies hollow TiO2 sonosensitizers, not only substantially improved activity Cu-mediated Fenton-like reaction, but also considerably augmented by facilitating separation electrons (e- holes (h+ ). Both in vitro vivo studies demonstrate that nanosonosensitizers effectively achieved inhibitory effect TNBC, providing paradigm non-invasive safe tumor elimination through mutual process sono/chemo-nanodynamic based multifunctional nanosonosensitizers.

Language: Английский

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H₂S‐Activated Ion‐Interference Therapy: A Novel Tumor Targeted Therapy Based on Copper‐Overload‐Mediated Cuproptosis and Pyroptosis

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(38)

Published: June 6, 2023

Abstract Copper overload is a novel way to achieve copper‐ion‐interference therapy by disrupting copper homeostasis and treating diseases through multiple cell death pathways. However, it difficult reach since excess intracellular ions will be pumped out. Herein, achieved both raising cellular uptake reducing the efflux of using hydrogen sulfide (H 2 S)‐responsive hydroxyphosphate nanoparticles (Cu (PO 4 )(OH) NPs). After immersion in an H S‐enriched colon cancer microenvironment, Cu NPs can transform into with reduced size for higher entering, resulting improved Fenton activity as well ion dissociation. Reactive oxygen species generated reaction not only activate inflammasomes Caspase‐1 proteins, cause cleavage gasdermin D induce pyroptosis, but also affect mitochondrial function down‐regulate exporter ATP7A further reduce excretion. The combination endocytosis lower exportation leads maximized overload. Together efficient release, tricarboxylic acid cycle disrupted iron‐sulfur cluster proteins are downregulated, ultimately triggering cuproptosis. As pyroptosis cuproptosis ways death, this study provides realize effective tumor‐targeted based on S‐activated simple NPs.

Language: Английский

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Efficient Therapy of Inflammatory Bowel Disease (IBD) with Highly Specific and Durable Targeted Ta₂C Modified with Chondroitin Sulfate (TACS)

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(36)

Published: May 24, 2023

Non-invasive localization of lesions and specific targeted therapy are still the main challenges for inflammatory bowel disease (IBD). Ta, as a medical metal element, has been widely used in treatment different diseases because its excellent physicochemical properties but is far from being explored IBD. Here, Ta2 C modified with chondroitin sulfate (CS) (TACS) evaluated highly nanomedicine Specifically, TACS dual targeting CS functions due to IBD lesion-specific positive charges high expression CD44 receptors. Thanks acid stability, sensitive CT imaging function, strong reactive oxygen species (ROS) elimination ability, oral can accurately locate delineate through non-invasive imaging, specifically treat effectively levels ROS central factor progression As expected, much better therapeutic effects than clinical contrast agent first-line drug 5-aminosalicylic acid, respectively. The mechanism mainly involves protection mitochondria, oxidative stress, inhibiting macrophage M1 polarization, intestinal barrier, restoration flora balance. Collectively, this work provides unprecedented opportunities nanomedicines

Language: Английский

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