NIR-II light in clinical oncology: opportunities and challenges

Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: 21(6), P. 449 - 467

Published: May 1, 2024

Language: Английский

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Near-infrared II fluorescence imaging

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: April 4, 2024

Language: Английский

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Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy

Redox Biology, Journal Year: 2023, Volume and Issue: 67, P. 102906 - 102906

Published: Oct. 4, 2023

Microvascular endothelial damage caused by intestinal ischemia‒reperfusion (II/R) is a primary catalyst for microcirculation dysfunction and enterogenous infection. Previous studies have mainly focused on how neutrophil extracellular traps (NETs) ferroptosis cause epithelial injury, little attention has been given to NETs, from circulatory neutrophils, affect cells during II/R. This study aimed unravel the mechanisms through which NETs microvascular dysfunction. We first detected heightened local NET infiltration around microvasculature, accompanied increased cell ferroptosis, resulting in both human animal II/R models. However, administration of inhibitor ferrostatin-1 or inhibition via neutrophil-specific peptidylarginine deiminase 4 (Pad4) deficiency led positive outcomes, with reduced function recovery. Moreover, RNA-seq analysis revealed significant enrichment mitophagy- ferroptosis-related signaling pathways HUVECs incubated NETs. Mechanistically, elevated formation induced Fundc1 phosphorylation at Tyr18 cells, mitophagy inhibition, mitochondrial quality control imbalance, excessive ROS generation lipid peroxidation, Nevertheless, using activator urolithin A AAV-Fundc1 transfection could reverse this process ameliorate damage. demonstrate that NETosis result microcirculatory conclude suppressed can mitigate improving Fundc1-dependent mitophagy. Targeting be promising approach treating II/R-induced

Language: Английский

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Recent advances in fluorescence imaging-guided photothermal therapy and photodynamic therapy for cancer: From near-infrared-I to near-infrared-II

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 425 - 445

Published: Sept. 8, 2023

Language: Английский

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Tuning Shortwave‐Infrared J‐aggregates of Aromatic Ring‐Fused Aza‐BODIPYs by Peripheral Substituents for Combined Photothermal and Photodynamic Therapies at Ultralow Laser Power

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(11)

Published: Jan. 16, 2024

Abstract Achieving photothermal therapy (PTT) at ultralow laser power density is crucial for minimizing photo‐damage and allowing higher maximum permissible skin exposure. However, this requires agents to possess not just superior conversion efficiency (PCE), but also exceptional near‐infrared (NIR) absorptivity. J ‐aggregates, exhibit a significant redshift narrower absorption peak with extinction coefficient. Nevertheless, achieving predictable ‐aggregates through molecular design remains challenge. In study, we successfully induced desirable J‐ aggregation (λ abs max : 968 nm, ϵ: 2.96×10 5 M −1 cm , λ em 972 Φ FL 6.2 %) by tuning electrostatic interactions between π‐conjugated planes manipulating surface potential of aromatic ring‐fused aza‐BODIPY dyes. Notably, controlling the preparation method encapsulating dyes into F‐127 polymer, were able selectively generate H ‐/ respectively. Furthermore, exhibited two controllable morphologies: nanospheres nanowires. Importantly, shortwave‐infrared ‐aggregated nanoparticles impressive PCE 72.9 % effectively destroyed cancer cells mice‐tumors an 0.27 W −2 (915 nm). This phototherapeutic nano‐platform, which generates behavior, can controllably form / H‐ aggregates selectable aggregate morphology, valuable paradigm developing tumor‐treatment density.

Language: Английский

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Ferroptosis boosted oral cancer photodynamic therapy by carrier-free Sorafenib-Ce6 self-assembly nanoparticles

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 798 - 811

Published: Jan. 25, 2024

Language: Английский

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“Three birds with one stone” nanoplatform: Efficient near‐infrared‐triggered type‑I AIE photosensitizer for mitochondria‐targeted photodynamic therapy against hypoxic tumors

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: March 24, 2024

Abstract Currently three major problems seriously limit the practical application of cancer photodynamic therapy (PDT): (i) hypoxic tumor microenvironment (TME); (ii) low generation efficiency toxic reactive oxygen species (ROS) in aggregates and (iii) shallow tissue penetration depth excitation light. Very limited approaches are available for addressing all above with a single design. Herein, rational “three birds one stone” molecular nanoengineering strategy is demonstrated: nanoplatform U‐Ir@PAA‐ABS based on covalent combination lanthanide‐doped upconversion nanoparticles (UCNPs) an AIE‐active dinuclear Ir(III) complex provides concentration‐dependent type‐I photochemical process upon 980 nm irradiation by Föster resonance energy transfer (FRET). targets mitochondria has excellent phototoxicity even severe hypoxia environments irradiation, inducing dual‐mode cell death mechanism apoptosis ferroptosis. Taken together, vitro vivo results demonstrate successful improving efficacy PDT against tumors.

Language: Английский

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Mitochondria-targeted fluorophore: State of the art and future trends

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 508, P. 215772 - 215772

Published: March 13, 2024

Language: Английский

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Lipid droplet‐targeted NIR AIE photosensitizer evoking concurrent ferroptosis and apoptosis

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Feb. 1, 2024

Abstract Lipid droplets (LDs), which are the hubs of lipid metabolism, play a critical role in maintaining cellular energy homeostasis. The construction advanced photosensitizers (PSs) capable manipulating LD‐mediated cell fate regulation is highly desirable though rarely reported. In this study, near‐infrared emissive PS (DPCMP) with LDs specificity was synthesized and successfully applied to induce ferroptosis apoptosis. DPCMP exhibited typical aggregation‐induced emission characteristics owing its twisted molecular conformation. Excellent biocompatibility suitable lipophilicity allowed specifically stain living cells. Under white light illumination, displayed potent reactive oxygen species (ROS) generation capacity through both type I II photochemistry. massive accumulation lethal ROS generated by DPCMP‐mediated photosensitization initiated peroxidation, impaired redox homeostasis, led endoplasmic reticulum oxidative stress, ultimately inhibiting proliferation via concurrent apoptosis cancer cells multicellular tumor spheroids.

Language: Английский

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pH/GSH dual responsive nanosystem for nitric oxide generation enhanced type I photodynamic therapy

Bioactive Materials, Journal Year: 2024, Volume and Issue: 34, P. 414 - 421

Published: Jan. 10, 2024

Tumor hypoxia diminishes the effectiveness of traditional type II photodynamic therapy (PDT) due to oxygen consumption. Type I PDT, which can operate independently oxygen, is a viable option for treating hypoxic tumors. In this study, we have designed and synthesized JSK@PEG-IR820 NPs that are responsive tumor microenvironment (TME) enhance PDT through glutathione (GSH) depletion. Our approach aims expand sources therapeutic benefits by promoting generation superoxide radicals (O

Language: Английский

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