In-situ Nanozyme Catalytic Amplification Coupled with a Universal Antibody Orientation Strategy based Electrochemical Immunosensor for AD-Related Biomarker

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 266, P. 116738 - 116738

Published: Sept. 3, 2024

Language: Английский

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Unleashing the Potential of Single-Atom Nanozymes: Catalysts for the Future

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(8), P. 3840 - 3847

Published: July 31, 2024

Single-atom nanozymes (SANs) have become a breakthrough in atomically precise catalysis, which relies on the catalytic active site formed by single-atom itself. From this angle, SANs and their advantages compared to natural enzymes as well spaces for application are emphasized. The outstanding control over activities; is with bulk materials enzymes. structure of has very promising potential next generation biosensing biomedical devices environmental remediation. Although capabilities high, difficulties still arise. specificity, scalability, biosafety, catalysis mechanisms raise additional issues that require further research. We build up vision perspectives better implementation SANs, designed diagnostic purposes, improving industrial technologies, creating new sustainable technologies food processing industry. AI machine learning systems may clarify structure–performance relationship improved material process selectivity. future promising, addressing these challenges leveraging advancements artificial intelligence science, powerful tools future.

Language: Английский

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Optical and Catalytic Properties of Nanozymes for Colorimetric Biosensors: Advantages, Limitations, and Perspectives

Advanced Optical Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Abstract Detection of colorimetric signals is commonly used in various analytical methods and for testing non‐laboratory resource‐limited settings. The performance assays largely based on nanoparticles their unique optical properties. Multifunctional combining enzyme‐like catalytic properties—known as nanozymes—hold great promise applications signal‐generating labels. However, the extensive focus properties leaves overlooked. In this article, use nanozymes reviewed relying inherent nanozymes, detection a catalytically‐formed product, changes caused by product. impact extinction coefficient reaction products, well kinetic parameters sensitivity limit assays, are quantitatively evaluated. Finally, existing limitations prospects biosensors summarized.

Language: Английский

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Recent advances on biomedical applications of zirconium-based Nanozymes: A review

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159464 - 159464

Published: Jan. 1, 2025

Language: Английский

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Integrated Microneedles and Hydrogel Biosensor Platform: Toward a Diagnostic Device for Collection and Dual-Mode Sensing of Monkeypox Virus A29 Protein

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

The outbreak of the monkeypox epidemic underscores importance developing a rapid and sensitive virus detection technique. Microneedles (MNs) offer minimally invasive sampling capabilities, providing solution for development integrated extraction diagnostic portable devices. Here, we report an MNs hydrogel biosensor (IMHB) platform, composed electronic device, MN patch, patch. IMHB allowed specific (MPXV) directly from lesional skin in both electrochemical colorimetric modes. A bifunctional signal probe 3,3′,5,5′-tetramethylbenzidine (TMB) was loaded measurable signals dual-mode sensing. Additionally, control area designed this platform to collect blank samples normal skin, enabling ratio analysis quality functions. This ratiometric sensing strategy exhibited wide range 10–1000 ng/mL MPXV A29 protein, with limits 0.1632 0.3017 assay, respectively. developed provides novel way on-site determination MPXV, demonstrating potential quick intervention early stages infectious diseases.

Language: Английский

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Nanozymes meet hydrogels: Fabrication, progressive applications, and perspectives

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 338, P. 103404 - 103404

Published: Jan. 23, 2025

Language: Английский

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Zinc Single-Atom Nanozyme As Carbonic Anhydrase Mimic for CO₂ Capture and Conversion

ACS Materials Au, Journal Year: 2025, Volume and Issue: 5(2), P. 377 - 384

Published: Jan. 31, 2025

Single-atom nanozymes (SANs) are a class of with metal centers that mimic the structure metalloenzymes. Herein, we report synthesis Zn–N–C SAN, which mimics action natural carbonic anhydrase enzyme. The two-step annealing technique led to content more than 18 wt %. Since act as active sites, this high loading resulted in superior catalytic activity. Zn-SAN showed CO2 uptake 2.3 mmol/g and final conversion bicarbonate 91%. was converted via biomimetic process by allowing its adsorption catalyst, followed addition catalyst HEPES buffer (pH = 8) start into HCO3–. Afterward, CaCl2 added form white CaCO3 precipitate, then filtered, dried, weighed. Active carbon MCM-41 were used controls under same reaction conditions. According findings, sequestration capacity 42 mg CaCO3/mg Zn-SAN. Some amino acids (AAs) binding affinity for Zn able suppress enzymatic activity blocking centers. This strategy detection His, Cys, Glu, Asp limits 0.011, 0.031, 0.029, 0.062 μM, respectively, hence utilized quantifying these AAs commercial dietary supplements.

Language: Английский

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Silicon dioxide-protection boosting the peroxidase-like activity of Fe single-atom catalyst for combining chemo-photothermal therapy

Nano Research, Journal Year: 2024, Volume and Issue: 17(6), P. 4924 - 4933

Published: Feb. 9, 2024

Language: Английский

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Heterojunction‐Mediated Co‐Adjustment of Band Structure and Valence State for Achieving Selective Regulation of Semiconductor Nanozymes

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: April 12, 2024

Improving reaction selectivity is the next target for nanozymes to mimic natural enzymes. Currently, majority of strategies in this field are exclusively applicable metal-organic-based or organic-based nanozymes, while limited regulating metal oxide-based semiconductor nanozymes. Herein, taking Co

Language: Английский

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A Cardiac‐Targeting and Anchoring Bimetallic Cluster Nanozyme Alleviates Chemotherapy‐Induced Cardiac Ferroptosis and PANoptosis

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Doxorubicin (DOX), a potent antineoplastic agent, is commonly associated with cardiotoxicity, necessitating the development of strategies to reduce its adverse effects on cardiac function. Previous research has demonstrated strong correlation between DOX‐induced cardiotoxicity and activation oxidative stress pathways. This work introduces novel antioxidant therapeutic approach, utilizing libraries tannic acid N‐acetyl‐L‐cysteine‐protected bimetallic cluster nanozymes. Through extensive screening for antioxidative enzyme‐like activity, an optimal nanozyme (AuRu) identified that possess remarkable characteristics, mimicking catalase‐like enzymes. Theoretical calculations reveal surface interactions prepared nanozymes simulate hydrogen peroxide decomposition process, showing these readily undergo OH⁻ adsorption O₂ desorption. To enhance targeting, atrial natriuretic peptide conjugated AuRu nanozyme. These cardiac‐targeted nanozymes, their anchoring capability, effectively cardiomyocyte ferroptosis PANoptosis without compromising tumor treatment efficacy. Thus, approach demonstrates significant reductions in chemotherapy‐induced cell death improvements function, accompanied by exceptional vivo biocompatibility stability. study presents promising avenue preventing offering potential clinical benefits cancer patients.

Language: Английский

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