Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 30, 2024
Abstract
Radiation
colitis
is
one
of
the
most
common
complications
in
patients
undergoing
pelvic
radiotherapy
and
there
no
effective
treatment
clinic.
Therefore,
searching
for
agents
radiation
urgently
needed.
Herein,
it
found
that
essential
element
selenium
(Se)
protective
against
through
inhibiting
X‐ray‐induced
apoptosis,
cell
cycle
arrest,
inflammation
with
involvement
balancing
generation
reactive
oxygen
species
after
irradiation.
Mechanistically,
Se,
especially
nanoparticles
(SeNPs),
induced
selenoprotein
expression
then
functioned
to
effectively
restrain
DNA
damage
response,
which
reduced
intestinal
injury.
Additionally,
SeNPs
also
restrained
cyclic
GMP‐AMP
synthas
(cGAS)‐
stimulator
interferon
genes
(STING)‐TBK1‐IRF3
signaling
pathway
cascade,
thereby
blocking
transcription
inflammatory
cytokine
gene,
IL‐6
TNF‐α,
thus
alleviating
inflammation.
Moreover,
inducing
expression,
such
as
GPX4,
vivo
can
regulate
microenvironment
immunity
gut
microbiota
attenuate
radiation‐induced
by
oxidative
stress
maintaining
homeostasis.
Together,
these
results
unravel
a
previously
unidentified
modulation
role
but
suppressing
cGAS‐STING‐TBK1‐IRF3
cascade.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: March 18, 2024
The
global
challenge
posed
by
cancer,
marked
rising
incidence
and
mortality
rates,
underscores
the
urgency
for
innovative
therapeutic
approaches.
PI3K/Akt
signaling
pathway,
frequently
amplified
in
various
cancers,
is
central
regulating
essential
cellular
processes.
Its
dysregulation,
often
stemming
from
genetic
mutations,
significantly
contributes
to
cancer
initiation,
progression,
resistance
therapy.
Concurrently,
ferroptosis,
a
recently
discovered
form
of
regulated
cell
death
characterized
iron-dependent
processes
lipid
reactive
oxygen
species
buildup,
holds
implications
diseases,
including
cancer.
Exploring
interplay
between
dysregulated
pathway
ferroptosis
unveils
potential
insights
into
molecular
mechanisms
driving
or
inhibiting
ferroptotic
cells.
Evidence
suggests
that
may
sensitize
cells
induction,
offering
promising
strategy
overcome
drug
resistance.
This
review
aims
provide
comprehensive
exploration
this
interplay,
shedding
light
on
disrupting
enhance
as
an
alternative
route
inducing
improving
treatment
outcomes.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
172, P. 116207 - 116207
Published: Jan. 31, 2024
Lung
cancer
ranks
among
the
most
prevalent
forms
of
and
remains
a
significant
factor
in
cancer-related
mortality
across
world.
It
poses
challenges
to
healthcare
systems
society
as
whole
due
its
high
incidence,
rates,
late-stage
diagnosis.
Resveratrol
(RV),
natural
compound
found
various
plants,
has
shown
potential
nanomedicine
for
lung
treatment.
RV
varied
effects
on
cells,
including
promoting
apoptosis
by
increasing
pro-apoptotic
proteins
(Bax
Bak)
decreasing
anti-apoptotic
(Bcl-2).
also
hinders
cell
proliferation
influencing
important
signaling
pathways
(MAPK,
mTOR,
PI3K/Akt,
Wnt/β-catenin)
that
govern
progression.
In
addition,
acts
potent
antioxidant,
diminishing
oxidative
stress
safeguarding
cells
against
DNA
damage.
However,
using
alone
treatment
drawbacks,
such
low
bioavailability,
lack
targeting
ability,
susceptibility
degradation.
contrast,
nanoparticle-based
delivery
address
these
limitations
hold
promise
improving
outcomes
cancer;
nanoparticle
formulations
offer
advantages
improved
drug
delivery,
increased
stability,
controlled
release,
targeted
cells.
This
article
will
provide
an
overview
cancer,
explore
therapeutic
agent,
discuss
benefits
highlight
nanoparticles
treatment,
cancer.
By
optimizing
clinical
application,
future
studies
aim
enhance
overall
improve
prognosis
patients.
Clinical and Translational Medicine,
Journal Year:
2024,
Volume and Issue:
14(6)
Published: May 28, 2024
Abstract
Copper,
a
trace
element
and
vital
cofactor,
plays
crucial
role
in
the
maintenance
of
biological
functions.
Recent
evidence
has
established
significant
correlations
between
copper
levels,
cancer
development
metastasis.
The
strong
redox‐active
properties
offer
both
benefits
disadvantages
to
cells.
intestinal
tract,
which
is
primarily
responsible
for
uptake
regulation,
may
suffer
from
an
imbalance
homeostasis.
Colorectal
(CRC)
most
prevalent
primary
tract
aggressive
malignant
disease
with
limited
therapeutic
options.
Current
research
focused
on
relationship
CRC.
Innovative
concepts,
such
as
cuproplasia
cuproptosis,
are
being
explored
understand
copper‐related
cellular
proliferation
death.
Cuproplasia
regulation
cell
that
mediated
by
enzymatic
nonenzymatic
copper‐modulated
activities.
Whereas,
cuproptosis
refers
death
induced
excess
via
promoting
abnormal
oligomerisation
lipoylated
proteins
within
tricarboxylic
acid
cycle,
well
diminishing
levels
iron‐sulphur
cluster
proteins.
A
comprehensive
understanding
mechanisms
offers
new
avenues
CRC
treatment.
In
this
review,
we
summarise
evolving
molecular
mechanisms,
ranging
intracellular
concentrations
discovered,
discuss
pathogenesis,
progression
potential
therapies
Understanding
will
help
provide
theoretical
foundation
innovative
treatment
strategies
management.
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Aug. 16, 2024
Cuproptosis
is
a
newly
identified
form
of
cell
death
induced
by
excessive
copper
(Cu)
accumulation
within
cells.
Mechanistically,
cuproptosis
results
from
Cu-induced
aggregation
dihydrolipoamide
S-acetyltransferase,
correlated
with
the
mitochondrial
tricarboxylic
acid
cycle
and
loss
iron–sulfur
cluster
proteins,
ultimately
resulting
in
proteotoxic
stress
triggering
death.
Recently,
has
garnered
significant
interest
tumor
research
due
to
its
potential
as
crucial
therapeutic
strategy
against
cancer.
In
this
review,
we
summarized
cellular
molecular
mechanisms
relationship
other
types
Additionally,
reviewed
current
drugs
or
strategies
available
induce
cells,
including
Cu
ionophores,
small
compounds,
nanomedicine.
Furthermore,
targeted
metabolism
specific
regulatory
genes
cancer
therapy
enhance
sensitivity
cuproptosis.
Finally,
discussed
feasibility
targeting
overcome
chemotherapy
immunotherapy
resistance
suggested
future
directions.
This
study
that
could
open
new
avenues
for
developing
therapy.
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
