Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(17)

Published: Jan. 31, 2023

Antimicrobial resistance (AMR) is one of the biggest threats to environment and health. AMR rapidly invalidates conventional antibiotics, antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several show AMR-independent effects without detectable new therefore suggested prevent evolution. In contrast, some are found trigger evolution AMR. Given these seemingly conflicting findings, a timely discussion two faces urgently needed. This review systematically compares killing mechanisms structure-activity relationships antibiotics nanomaterials. We then focus on nano-microbe interactions elucidate impacts molecular initiating events Finally, we provide an outlook future propose design principles for prevention

Language: Английский

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Carbon‐Based Nanomaterials for Cancer Therapy via Targeting Tumor Microenvironment

Advanced Healthcare Materials, Journal Year: 2018, Volume and Issue: 7(20)

Published: Aug. 2, 2018

Abstract Cancer remains one of the major health problems all over world and conventional therapeutic approaches have failed to attain an effective cure. Tumor microenvironments (TME) present a unique challenge in tumor therapy due their complex structures multiple components, which also serve as soil for growth, development, invasion, migration. The TME includes immune cells, fibrous collagen structures, tortuous blood vessels, are rendered useless. State‐of‐the‐art nanotechnologies potential cope with threats malignant tumors. With physiochemical properties, carbon nanomaterials (CNMs), including graphene, fullerenes, nanotubes, quantum dots, offer opportunities resolve hurdles, by targeting not only cancer cells but TME. This review summarizes progress about CNM‐based strategies, mainly focuses on both treatment TME‐targeted modulation. In last, challenges TME‐based via CNMs discussed, will be important guiding current basic research clinical translation future.

Language: Английский

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Molybdenum derived from nanomaterials incorporates into molybdenum enzymes and affects their activities in vivo

Nature Nanotechnology, Journal Year: 2021, Volume and Issue: 16(6), P. 708 - 716

Published: Feb. 18, 2021

Language: Английский

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Chemical and Biophysical Signatures of the Protein Corona in Nanomedicine

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(21), P. 9184 - 9205

Published: May 10, 2022

An inconvenient hurdle in the practice of nanomedicine is protein corona, a spontaneous collection biomolecular species by nanoparticles living systems. The corona dynamic composition and may entail improved water suspendability compromised delivery targeting to nanoparticles. How much this nonspecific ensemble determined chemistry nanoparticle core its surface functionalization, how entity dictated biological environments that vary spatiotemporally vivo? do we "live with" exploit without significantly sacrificing efficacy nanomedicines diagnosing curing human diseases? This article discusses chemical biophysical signatures ponders challenges ahead for field nanomedicine.

Language: Английский

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Rapid Degradation and High Renal Clearance of Cu₃BiS₃ Nanodots for Efficient Cancer Diagnosis and Photothermal Therapy in Vivo

ACS Nano, Journal Year: 2016, Volume and Issue: 10(4), P. 4587 - 4598

Published: March 25, 2016

A key challenge for the use of inorganic nanomedicines in clinical applications is their long-term accumulation internal organs, which raises common concern risk adverse effects and inflammatory responses. It thus necessary to rationally design nanomaterials with proper clearance mechanism vivo. Herein, we prepared ultrasmall Cu3BiS3 nanodots (NDs) as a single-phased ternary bimetal sulfide photothermal cancer therapy guided by multispectral optoacoustic tomography (MSOT) X-ray computed (CT) due bismuth's excellent attenuation coefficient. We then monitored investigated absorption, distribution, metabolism, excretion. also used CT imaging demonstrate that NDs can be quickly removed through renal clearance, may related small size, rapid chemical transformation, degradation an acidic lysosomal environment characterized synchrotron radiation-based absorption near-edge structure spectroscopy. These results reveal act simple but powerful "theranostic" nanoplatform MSOT/CT imaging-guided tumor ablation metabolism will improve safety future.

Language: Английский

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A Safe‐by‐Design Strategy towards Safer Nanomaterials in Nanomedicines

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(45)

Published: Jan. 30, 2019

Abstract The marriage of nanotechnology and medicine offers new opportunities to fight against human diseases. Benefiting from their unique optical, thermal, magnetic, or redox properties, a wide range nanomaterials have shown potential in applications such as diagnosis, drug delivery, tissue repair regeneration. Despite the considerable success achieved over past decades, newly emerging nanomedicines still suffer an incomplete understanding safety risks, relationships between physicochemical characteristics profiles. Herein, most important categories with clinical toxicological mechanisms are summarized, then, based on this available information, overview principles developing safe‐by‐design for medical recent progress field is provided. These may serve starting point guide development more effective strategies help identify major knowledge skill gaps.

Language: Английский

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Fabrication of Silver Nanoparticles Against Fungal Pathogens

Frontiers in Nanotechnology, Journal Year: 2021, Volume and Issue: 3

Published: Oct. 8, 2021

The use of silver nanoparticles (AgNPs) against various pathogens is now being well recognized in the agriculture and health sector. Nanoparticles have been shown to exhibit novel properties these properties, on other hand, rely upon size, shape, morphology particles. Moreover, physical characteristics enable them interact with microbes, plants, animals. Smaller-sized particles more toxicity than larger-sized nanoparticles. AgNPs growth inhibition many fungi like Aspergillus fumigates , A. niger flavus Trichophyton rubrum Candida albicans Penicillium species. According current hypothesis, act by producing reactive oxygen species free radicals, which cause protein denaturation, nucleic acid proton pump damage, lipid peroxidation, cell wall damage. Therefore, they alter membrane permeability, causing death. This mini-review summarizes fungal biofilm agricultural

Language: Английский

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Toxicity of manufactured nanomaterials

Particuology, Journal Year: 2021, Volume and Issue: 69, P. 31 - 48

Published: Nov. 30, 2021

Manufactured nanomaterials with unique properties have been extensively applied in various industrial, agricultural or medical fields. However, some of the identified to be closely related nanomaterial toxicity. The "nano-paradox" has aroused concerns over use and development nanotechnology, which makes it difficult for regulatory agencies regulate nanomaterials. key fulfilling proper regulation lies adequate understanding impact on nano-bio interactions. To this end, we start present work a brief introduction interactions at different levels. Based that, how toxicity-associated manufactured (i.e., size, shape, chemical composition, surface properties, biocorona formation, agglomeration and/or aggregation state, biodegradability) their toxicokinetics, cellular uptake, trafficking responses, toxicity mechanisms is deeply explored. Moreover, advanced analytical methods studying are introduced. Furthermore, current legislative frameworks nanomaterial-containing products regions countries presented. Finally, propose several challenges facing nanotoxicology field possible solutions shed light safety evaluation

Language: Английский

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Silver nanoparticle enhanced metal-organic matrix with interface-engineering for efficient photocatalytic hydrogen evolution

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Feb. 1, 2023

Abstract Integrating plasmonic nanoparticles into the photoactive metal-organic matrix is highly desirable due to near field enhancement, complementary light absorption, and accelerated separation of photogenerated charge carriers at junction interface. The construction a well-defined, intimate interface vital for efficient carrier separation, however, it remains challenge in synthesis. Here we synthesize bearing interface, composed Ag with silver node via facile one-step approach. effect on visualized through electron energy loss mapping. Moreover, transfer from verified ultrafast transient absorption spectroscopy in-situ photoelectron spectroscopy. system delivers visible-light photocatalytic H 2 generation, surpassing most reported framework-based systems. This work sheds effective electronic bridging between organic semiconductors.

Language: Английский

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Current Overview of Metal Nanoparticles’ Synthesis, Characterization, and Biomedical Applications, with a Focus on Silver and Gold Nanoparticles

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(10), P. 1410 - 1410

Published: Oct. 4, 2023

Metal nanoparticles (NPs) have garnered considerable attention, due to their unique physicochemical properties, that render them promising candidates for various applications in medicine and industry. This article offers a comprehensive overview of the most recent advancements manufacturing, characterization, biomedical utilization metal NPs, with primary focus on silver gold NPs. Their potential as effective anticancer, anti-inflammatory, antimicrobial agents, drug delivery systems, imaging agents diagnosis treatment variety disorders is reviewed. Moreover, translation therapeutic settings, issue inclusion clinical trials, are assessed light over 30 investigations concentrate administering either or NPs conditions ranging from nosocomial infections different types cancers. paper aims not only examine biocompatibility nanomaterials but also emphasize challenges may limit safe integration into healthcare practices. More than 100 nanomedicines currently market, which justifies ongoing study use medicine. Overall, present review highlight innovative therapeutics field biomedicine, citing some relevant current applications.

Language: Английский

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