Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

Frontiers in Microbiology, Journal Year: 2018, Volume and Issue: 9

Published: July 2, 2018

Infectious diseases remain one of the leading causes morbidity and mortality worldwide. The WHO CDC have expressed serious concern regarding continued increase in development multidrug resistance among bacteria. Therefore, antibiotic crisis is most pressing issues global public health. Associated with rise lack new antimicrobials. This has triggered initiatives worldwide to develop novel more effective antimicrobial compounds as well delivery targeting strategies. Bacteria developed many ways by which they become resistant Among those are enzyme inactivation, decreased cell permeability, target protection, overproduction, altered site/enzyme, increased efflux due over-expression pumps, others. Other complex phenotypes, such biofilm formation quorum sensing do not appear a result exposure bacteria antibiotics although, it known that can be induced antibiotics. These phenotypes related tolerance Different strategies, use nanostructured materials, being overcome these other types resistance. Nanostructured materials used convey antimicrobials, assist drugs or ultimately, possess activity themselves. Additionally, nanoparticles (e.g., metallic, organic, carbon nanotubes, etc.) may circumvent drug mechanisms and, associated their potential, inhibit important processes. including combined plant-based antimicrobials toxicity issues, also investigated. Coupling natural-based (or repurposed compounds) bacterial pumps; biofilms; interference sensing; possibly plasmid curing, just some strategies combat However, still presents challenge therapy much research needed order this. In this review, we will summarize current on nanomaterials how applied future fight

Language: Английский

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Second near-infrared photothermal materials for combinational nanotheranostics

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 1111 - 1137

Published: Nov. 27, 2020

This review summarizes the recent development of second near-infrared photothermal combinational nanotheranostics for cancer, infectious diseases and regenerative medicine.

Language: Английский

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Physical Double‐Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self‐Healing, Antioxidant and NIR/pH Stimulus‐Responsiveness for Multidrug‐Resistant Bacterial Infection and Removable Wound Dressing

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(17)

Published: Feb. 28, 2020

Abstract Developing physical double‐network (DN) removable hydrogel adhesives with both high healing efficiency and photothermal antibacterial activities to cope multidrug‐resistant bacterial infection, wound closure, remains an ongoing challenge. An injectable DN self‐healing adhesive under physiological conditions is designed treat bacteria infection full‐thickness skin incision/defect repair. The consists of catechol–Fe 3+ coordination cross‐linked poly(glycerol sebacate)‐ co ‐poly(ethylene glycol)‐ g ‐catechol quadruple hydrogen bonding ureido‐pyrimidinone modified gelatin. It possesses excellent anti‐oxidation, NIR/pH responsiveness, shape adaptation. Additionally, the presents rapid self‐healing, good tissue adhesion, degradability, activity, NIR irradiation and/or acidic solution washing‐assisted removability. In vivo experiments prove that hydrogels have hemostasis trauma killing ratio for methicillin‐resistant staphylococcus aureus (MRSA) achieve better closure incision than medical glue surgical suture. particular, they can significantly promote defect by regulating inflammation, accelerating collagen deposition, promoting granulation formation, vascularization. These on‐demand dissolvable antioxidant are multifunctional dressings treating in MRSA healing.

Language: Английский

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Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(2), P. 428 - 446

Published: Jan. 1, 2019

Bacterial-infections are mostly due to bacteria in their biofilm-mode of growth. Nanotechnology-based antimicrobials possess excellent potential biofilm-infection control, overcoming the biological barriers biofilms.

Language: Английский

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Antibiotic‐Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(18)

Published: Dec. 3, 2019

Bacterial infection is one of the top ten leading causes death globally and worst killer in low-income countries. The overuse antibiotics leads to ever-increasing antibiotic resistance, posing a severe threat human health. Recent advances nanotechnology provide new opportunities address challenges bacterial by killing germs without using antibiotics. Antibiotic-free antibacterial strategies enabled advanced nanomaterials are presented. Nanomaterials classified on basis their mode action: with intrinsic or light-mediated bactericidal properties others that serve as vehicles for delivery natural compounds. Specific attention given mechanisms structure-performance relationship. Practical applications employing these antibiotic-free also introduced. Current this field future perspectives presented stimulate technologies translation fight against infection.

Language: Английский

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Near-Infrared Light-Triggered Nitric-Oxide-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy for Biofilm Elimination

ACS Nano, Journal Year: 2020, Volume and Issue: 14(3), P. 3546 - 3562

Published: Feb. 18, 2020

Photothermal treatment (PTT) involving a combination of therapeutic modalities recently emerged as an efficient alternative for combating biofilm. However, PTT-related local high temperature may destroy the surrounding healthy tissues. Herein, we present all-in-one phototherapeutic nanoplatform consisting l-arginine (l-Arg), indocyanine green (ICG), and mesoporous polydopamine (MPDA), namely, AI-MPDA, to eliminate already-formed The fabrication process included surface modification MPDA with l-Arg further adsorption ICG via π–π stacking. Under near-infrared (NIR) exposure, AI-MPDA not only generated heat but also produced reactive oxygen species, causing cascade catalysis release nitric oxide (NO). NIR irradiation, biofilm elimination was attributed NO-enhanced photodynamic therapy low-temperature PTT (≤45 °C). Notably, NIR-triggered strategy resulted in severe destruction bacterial membranes. displayed good cytocompatibility. NIR-irradiated nanoparticles prevented colonization realized rapid recovery infected wounds. More importantly, platform effective efficiency around 100% abscess formation model. Overall, this provides reliable tool biofilms clinical applications.

Language: Английский

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Staphylococcal Biofilm Development: Structure, Regulation, and Treatment Strategies

Microbiology and Molecular Biology Reviews, Journal Year: 2020, Volume and Issue: 84(3)

Published: Aug. 11, 2020

In many natural and clinical settings, bacteria are associated with some type of biotic or abiotic surface that enables them to form biofilms, a multicellular lifestyle embedded in an extracellular matrix.

Language: Английский

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Supramolecular Antibacterial Materials for Combatting Antibiotic Resistance

Advanced Materials, Journal Year: 2018, Volume and Issue: 31(5)

Published: Dec. 7, 2018

Abstract Antibiotic‐resistant bacteria have emerged as a severe threat to human health. As effective antibacterial therapies, supramolecular materials display unprecedented advantages because of the flexible and tunable nature their noncovalent interactions with biomolecules ability incorporate various active agents in platforms. Herein, are discussed using format that focuses on fundamental elements recent advances including material selection, fabrication methods, structural characterization, activity performance.

Language: Английский

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Zinc-doped Prussian blue enhances photothermal clearance of Staphylococcus aureus and promotes tissue repair in infected wounds

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Oct. 3, 2019

Abstract The application of photothermal therapy to treat bacterial infections remains a challenge, as the high temperatures required for elimination can damage healthy tissues. Here, we develop an exogenous antibacterial agent consisting zinc-doped Prussian blue (ZnPB) that kills methicillin-resistant Staphylococcus aureus in vitro and rat model cutaneous wound infection. Local heat triggered by effect accelerates release penetration ions into bacteria, resulting alteration intracellular metabolic pathways killing without systemic toxicity. ZnPB treatment leads upregulation genes involved tissue remodeling, promotes collagen deposition enhances repair. efficient conversion allows use relatively few doses low laser flux, making platform potential alternative current antibiotic therapies against infections.

Language: Английский

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Nanomaterials with a photothermal effect for antibacterial activities: an overview

Nanoscale, Journal Year: 2019, Volume and Issue: 11(18), P. 8680 - 8691

Published: Jan. 1, 2019

Nanomaterials and nanotechnologies have been expected to provide innovative platforms for addressing antibacterial challenges, with potential even deal bacterial infections involving drug-resistance. The current review summarizes recent progress over the last 3 years in field of nanomaterials a photothermal conversion effect. We classify these into four functional categories: carbon-based nanoconjugates graphene derivatives or carbon nanotubes, noble metal mainly from gold silver, metallic compound nanocomposites such as copper sulfide molybdenum sulfide, polymeric well other nanostructures. Different categories can be assembled each enhance effects activities. describes their fabrication processes, unique properties, modes, healthcare applications.

Language: Английский

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