A Semiconducting Polymer Nano‐prodrug for Hypoxia‐Activated Photodynamic Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(18), P. 5920 - 5924

Published: Feb. 22, 2019

Photodynamic therapy (PDT) holds great promise for cancer therapy; however, its efficacy is often compromised by tumor hypoxia. Herein, we report the synthesis of a semiconducting polymer nanoprodrug (SPNpd) that not only efficiently generates singlet oxygen (1 O2 ) under NIR photoirradiation but also specifically activates chemotherapeutic action in hypoxic microenvironment. SPNpd self-assembled from amphiphilic brush, which comprises light-responsive photodynamic backbone grafted with poly(ethylene glycol) and conjugated chemodrug through hypoxia-cleavable linkers. The well-defined compact nanostructure (30 nm) enables accumulation living mice. Owing to these features, exerts synergistic chemo-therapy, effectively inhibits growth xenograft mouse model. This study represents first hypoxia-activatable phototherapeutic polymeric prodrug system high potential therapy.

Language: Английский

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<p>Cancer-Derived Exosomes: Their Role in Cancer Biology and Biomarker Development</p>

International Journal of Nanomedicine, Journal Year: 2020, Volume and Issue: Volume 15, P. 8019 - 8036

Published: Oct. 1, 2020

Abstract: Exosomes are a subset of tiny extracellular vesicles manufactured by all cells and present in body fluids. They produced actively tumor cells, which released utilized to facilitate growth. Their characteristics enable them assist major cancer hallmarks, leveraged fostering growth spread while implementing ways escape elimination from the host environment. This review updates on latest progress roles cancer-derived exosomes, 30– 100 nm size, deregulating paracrine trafficking microenvironment circulation. Thus, exosomes being exploited diagnostic biomarker development, with its potential clinical applications as therapeutic targets exosome‐based nanoparticle drug delivery strategies for therapy. Ongoing studies were retrieved PubMed ® Scopus database ClinicalTrials.gov registry review, highlighting how entirely different cell lines rely genetic information carried their homotypic heterotypic intercellular communications favor proliferation invasion, establishing pre-metastatic niche welcoming cells’ arrival. We will elaborate tumor-derived proliferation, metastasis hematopoietic (leukemia myeloma), epithelial (breast cancer), mesenchymal (soft tissue sarcoma osteosarcoma) cancers. Cancer-derived exosomal is observed several types liquid or solid tumors, confirming role hallmark enabler. enriched signals arising characteristic DNA, RNA, microRNA, lncRNA, along specific gene expression profiles, protein, lipid composition cargo shed into blood, saliva, urine, ascites, cervicovaginal lavage, studied diagnostic, prognostic, predictive biomarker. reveal research efforts exploiting use nanoparticles improve overall capability clinic. Keywords: tumor-released carcinoma-associated fibroblasts, exosome cargo, exosome-induced chemoresistance, hallmarks cancer, tumor-stromal

Language: Английский

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Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications

Nano-Micro Letters, Journal Year: 2019, Volume and Issue: 11(1)

Published: Nov. 16, 2019

Abstract Cell membrane coating technology is an approach to the biomimetic replication of cell properties, and active area ongoing research readily applicable nanoscale biomedicine. Nanoparticles (NPs) coated with membranes offer opportunity unite natural properties those artificial inner core material. The NPs not only increase their biocompatibility but also achieve effective extended circulation in vivo, allowing for execution targeted functions. Although membrane-coated clear advantages, much work remains before they can be applied clinical practice. In this review, we first provide a comprehensive overview theory technology, followed by summary existing preparation characterization techniques. Next, focus on functions applications various types. addition, collate model drugs used review patent related from past 10 years. Finally, survey future challenges trends pertaining effort development technology.

Language: Английский

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Nanomedicine in cancer therapy

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Aug. 7, 2023

Cancer remains a highly lethal disease in the world. Currently, either conventional cancer therapies or modern immunotherapies are non-tumor-targeted therapeutic approaches that cannot accurately distinguish malignant cells from healthy ones, giving rise to multiple undesired side effects. Recent advances nanotechnology, accompanied by our growing understanding of biology and nano-bio interactions, have led development series nanocarriers, which aim improve efficacy while reducing off-target toxicity encapsulated anticancer agents through tumor tissue-, cell-, organelle-specific targeting. However, vast majority nanocarriers do not possess hierarchical targeting capability, their indices often compromised poor accumulation, inefficient cellular internalization, inaccurate subcellular localization. This Review outlines current prospective strategies design organelle-targeted nanomedicines, highlights latest progress technologies can dynamically integrate these three different stages static maximize outcomes. Finally, we briefly discuss challenges future opportunities for clinical translation nanomedicines.

Language: Английский

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Organic Semiconducting Pro‐nanostimulants for Near‐Infrared Photoactivatable Cancer Immunotherapy

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(36), P. 12680 - 12687

Published: July 6, 2019

Abstract In this study, an organic semiconducting pro‐nanostimulant (OSPS) with a near‐infrared (NIR) photoactivatable immunotherapeutic action for synergetic cancer therapy is presented. OSPS comprises polymer nanoparticle (SPN) core and immunostimulant conjugated through singlet oxygen ( 1 O 2 ) cleavable linkers. Upon NIR laser irradiation, generates both heat to exert combinational phototherapy not only ablate tumors but also produce tumor‐associated antigens. More importantly, irradiation triggers the cleavage of ‐cleavable linkers, triggering remote release immunostimulants from modulate immunosuppressive tumor microenvironment. Thus, released antigens in conjunction activated induce synergistic antitumor immune response after OSPS‐mediated phototherapy, resulting inhibited growth primary/distant lung metastasis mouse xenograft model, which observed sole phototherapy.

Language: Английский

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An Ultrasound Activated Vesicle of Janus Au‐MnO Nanoparticles for Promoted Tumor Penetration and Sono‐Chemodynamic Therapy of Orthotopic Liver Cancer

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 59(4), P. 1682 - 1688

Published: Nov. 11, 2019

Sonodynamic therapy (SDT) has the advantages of high penetration, non-invasiveness, and controllability, it is suitable for deep-seated tumors. However, there still a lack effective sonosensitizers with sensitivity, safety, penetration. Now, ultrasound (US) glutathione (GSH) dual responsive vesicles Janus Au-MnO nanoparticles (JNPs) were coated PEG ROS-sensitive polymer. Upon US irradiation, disassembled into small (NPs) promoted penetration ability. Subsequently, GSH-triggered MnO degradation simultaneously released smaller Au NPs as numerous cavitation nucleation sites Mn2+ chemodynamic (CDT), resulting in enhanced reactive oxygen species (ROS) generation. This also allowed dual-modality photoacoustic imaging second near-infrared (NIR) window T1 -MR due to , inhibited orthotopic liver tumor growth via synergistic SDT/CDT.

Language: Английский

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Photoactivatable Organic Semiconducting Pro-nanoenzymes

Journal of the American Chemical Society, Journal Year: 2019, Volume and Issue: 141(9), P. 4073 - 4079

Published: Feb. 11, 2019

Therapeutic enzymes hold great promise for cancer therapy; however, in vivo remote control of enzymatic activity to improve their therapeutic specificity remains challenging. This study reports the development an organic semiconducting pro-nanoenzyme (OSPE) with a photoactivatable feature metastasis-inhibited therapy. Upon near-infrared (NIR) light irradiation, this not only generates cytotoxic singlet oxygen (1O2) photodynamic therapy (PDT), but also triggers spontaneous cascade reaction induce degradation ribonucleic acid (RNA) specifically tumor microenvironment. More importantly, OSPE-mediated RNA is found downregulate expression metastasis-related proteins, contributing inhibition metastasis after treatment. Such photoactivated and cancer-specific synergistic action OSPE enables complete growth lung mouse xenograft model, which possible counterpart PDT nanoagent. Thus, our proposes phototherapeutic-proenzyme approach toward complete-remission

Language: Английский

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Multifunctional phototheranostic nanomedicine for cancer imaging and treatment

Materials Today Bio, Journal Year: 2019, Volume and Issue: 5, P. 100035 - 100035

Published: Nov. 7, 2019

Cancer, as one of the most life-threatening diseases, shows a high fatality rate around world. When improving therapeutic efficacy conventional cancer treatments, researchers also conduct extensive studies into alternative approaches, which are safe, valid, and economical. Phototherapies, including photodynamic therapy (PDT) photothermal (PTT), tumor-ablative function-reserving oncologic interventions, showing strong potential in clinical treatment. During phototherapies, non-toxic phototherapeutic agents can be activated upon light irradiation to induce cell death without causing much damage normal tissues. Besides, with rapid development nanotechnology past decades, phototheranostic nanomedicine has attracted tremendous interests aiming continuously refine their performance. Herein, we reviewed recent progress for improved therapy. After brief introduction principles related PDT PTT, existing works on developing by mainly focusing categories applications, particularly phototherapy-synergized immunotherapy, comprehensively reviewed. More importantly, conclusion future challenges from our point view delivered last part this article.

Language: Английский

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Cell membrane biomimetic nanoparticles for inflammation and cancer targeting in drug delivery

Biomaterials Science, Journal Year: 2019, Volume and Issue: 8(2), P. 552 - 568

Published: Nov. 11, 2019

Cell membrane coated nanoparticles have been designed for inflammation and cancer therapy. An array of cell membranes from library were extracted leveraged to coat a variety different diseases.

Language: Английский

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Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(9), P. 5505 - 5616

Published: April 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Language: Английский

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