Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(50)
Published: Sept. 8, 2021
Abstract
Multiple
enzyme‐driven
biological
catalytic
cascades
occur
in
living
organisms,
guiding
highly
efficient
and
selective
transformations
of
substrates.
Inspired
by
the
merits
these
cascade
systems,
enormous
efforts
have
been
devoted
to
developing
novel
systems
mimic
reactions
over
past
few
years.
Nanozymes,
a
class
enzyme
mimics,
are
nanomaterials
with
enzyme‐like
activity.
The
emergence
development
nanozymes
has
significantly
advanced
biomimetic
nanoreactors.
Currently,
nanoreactors
driven
widely
used
exhibit
many
advantages
such
as
superior
efficiency
high
stability,
resulting
significant
advancements
biosensing
biomedical
applications.
latest
advances
understanding
mechanism
nanozyme‐engineered
their
progressive
applications
for
comprehensively
covered
here.
First,
nanozyme
enzyme/nanozyme‐engineered
categorized
according
properties.
Then,
applications,
including
cancer
therapy,
antibacterial
activity,
antioxidation,
hyperuricemia
therapy
covered.
conclusion
describes
most
important
challenges
opportunities
remaining
this
exciting
area
research.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(7)
Published: Jan. 4, 2021
Chemodynamic
therapy
(CDT)
is
an
emerging
method
that
kills
cancer
cells
by
converting
intracellular
hydrogen
peroxide
(H2
O2
)
into
highly
toxic
hydroxyl
radicals
(•
OH).
To
overcome
the
current
limitations
of
insufficient
endogenous
H2
and
high
concentration
glutathione
(GSH)
in
tumor
cells,
intelligent
nanocatalytic
theranostics
(denoted
as
PGC-DOX)
possesses
both
self-supply
GSH-elimination
properties
for
efficient
presented.
This
nanoplatform
constructed
a
facile
one-step
biomineralization
using
poly(ethylene
glycol)-modified
glucose
oxidase
(GOx)
template
to
form
biodegradable
copper-doped
calcium
phosphate
nanoparticles,
followed
loading
doxorubicin
(DOX).
As
enzyme
catalyst,
GOx
can
effectively
catalyze
generate
,
which
not
only
starves
but
also
supplies
subsequent
Fenton-like
reaction.
Meanwhile,
redox
reaction
between
released
Cu2+
ions
GSH
will
induce
depletion
reduce
Fenton
agent
Cu+
ions,
then
trigger
•
OH
-mediated
reaction,
resulting
enhanced
CDT
efficacy.
The
integration
GOx-mediated
starvation
therapy,
CDT,
DOX-induced
chemotherapy,
endow
PGC-DOX
with
effective
growth
inhibition
minimal
side
effects
vivo.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(4), P. 1981 - 2019
Published: Jan. 25, 2021
Since
the
first
connection
between
Fenton
chemistry
and
biomedicine,
numerous
studies
have
been
presented
in
this
field.
Comprehensive
presentation
of
guidance
from
a
summary
its
representative
applications
cancer
therapy
would
help
us
understand
promote
further
development
This
comprehensive
review
supplies
basic
information
regarding
chemistry,
including
reactions
Fenton-like
reactions.
Subsequently,
current
progress
is
discussed,
with
some
corresponding
examples
presented.
Furthermore,
strategies
for
optimizing
performance
chemodynamic
guided
by
are
highlighted.
Most
importantly,
future
perspectives
on
combination
biomedicine
or
wider
range
catalytic
approaches
We
hope
that
will
attract
positive
attention
materials
science,
fields
tighten
their
connections.
Small,
Journal Year:
2021,
Volume and Issue:
18(6)
Published: Nov. 2, 2021
Abstract
Chemodynamic
therapy
(CDT),
a
novel
cancer
therapeutic
strategy
defined
as
the
treatment
using
Fenton
or
Fenton‐like
reaction
to
produce
•OH
in
tumor
region,
was
first
proposed
by
Bu,
Shi,
and
co‐workers
2016.
Recently,
with
rapid
development
of
nanomaterials,
CDT
has
attracted
tremendous
attention
because
its
unique
advantages:
1)
It
is
tumor‐selective
low
side
effects;
2)
process
does
not
depend
on
external
field
stimulation;
3)
it
can
modulate
hypoxic
immunosuppressive
microenvironment;
4)
cost
low.
In
addition
Fe‐involved
strategies,
reaction‐mediated
strategies
have
also
been
proposed,
which
are
based
many
other
metal
elements
including
copper,
manganese,
cobalt,
titanium,
vanadium,
palladium,
silver,
molybdenum,
ruthenium,
tungsten,
cerium,
zinc.
Moreover,
combined
therapies
like
chemotherapy,
radiotherapy,
phototherapy,
sonodynamic
therapy,
immunotherapy
for
achieving
enhanced
anticancer
effects.
Besides,
there
studies
that
extend
application
antibacterial
field.
This
review
introduces
latest
advancements
nanomaterials‐involved
from
2018
present
proposes
current
limitations
well
future
research
directions
related
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(15), P. 8669 - 8742
Published: Jan. 1, 2021
Inorganic
nanomaterials
that
have
inherently
exceptional
physicochemical
properties
(e.g.,
catalytic,
optical,
thermal,
electrical,
or
magnetic
performance)
can
provide
desirable
functionality
drug
delivery,
diagnostics,
imaging,
therapy)
considerable
potential
for
application
in
the
field
of
biomedicine.
However,
toxicity
be
caused
by
long-term,
non-specific
accumulation
these
inorganic
healthy
tissues,
preventing
their
large-scale
clinical
utilization.
Over
past
several
decades,
emergence
biodegradable
and
clearable
has
offered
to
prevent
such
long-term
toxicity.
In
addition,
a
comprehensive
understanding
design
metabolic
pathways
within
body
is
essential
enabling
expansion
theranostic
applications
various
diseases
advancing
trials.
Thus,
it
critical
importance
develop
biomedical
applications.
This
review
systematically
summarizes
recent
progress
nanomaterials,
particularly
cancer
theranostics
other
disease
therapies.
The
future
prospects
opportunities
this
rapidly
growing
are
also
discussed.
We
believe
timely
will
stimulate
guide
additional
in-depth
studies
area
nanomedicine,
as
rapid
vivo
clearance
degradation
likely
prerequisite
translation
with
unique
functionality.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(48)
Published: Sept. 27, 2021
Chemodynamic
therapy
(CDT)
uses
the
tumor
microenvironment-assisted
intratumoral
Fenton
reaction
for
generating
highly
toxic
hydroxyl
free
radicals
(•OH)
to
achieve
selective
treatment.
However,
limited
efficiency
restricts
therapeutic
efficacy
of
CDT.
Recent
years
have
witnessed
impressive
development
various
strategies
increase
reaction.
The
introduction
these
reinforcement
can
dramatically
improve
treatment
CDT
and
further
promote
enhanced
(ECDT)-based
multimodal
anticancer
treatments.
In
this
review,
authors
systematically
introduce
strategies,
from
their
basic
working
principles,
mechanisms
representative
clinical
applications.
Then,
ECDT-based
is
discussed,
including
how
integrate
emerging
accelerating
therapy,
as
well
synergistic
ECDT
other
methods.
Eventually,
future
direction
challenges
therapies
are
elaborated,
highlighting
key
scientific
problems
unsolved
technical
bottlenecks
facilitate
translation.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Feb. 22, 2022
Nanozyme
is
a
series
of
nanomaterials
with
enzyme-mimetic
activities
that
can
proceed
the
catalytic
reactions
natural
enzymes.
In
field
biomedicine,
nanozymes
are
capturing
tremendous
attention
due
to
their
high
stability
and
low
cost.
Enzyme-mimetic
be
regulated
by
multiple
factors,
such
as
chemical
state
metal
ion,
pH,
hydrogen
peroxide
(H2O2),
glutathione
(GSH)
level,
presenting
great
promise
for
biomedical
applications.
Over
past
decade,
multi-functional
have
been
developed
various
To
promote
understandings
development
novel
multifunctional
nanozymes,
we
herein
provide
comprehensive
review
applications
in
field.
Nanozymes
versatile
enzyme-like
properties
briefly
overviewed,
mechanism
application
discussed
future
research.
Finally,
underlying
challenges
prospects
frontier
this
review.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(13)
Published: March 1, 2021
Abstract
Nanotheranostic
agents
of
gold
nanomaterials
in
the
second
near‐infrared
(NIR‐II)
window
have
attracted
significant
attention
cancer
management,
owing
to
reduced
background
signal
and
deeper
penetration
depth
tissues.
However,
it
is
still
challenging
modulate
localized
surface
plasmon
resonance
(LSPR)
from
first
(NIR‐I)
NIR‐II
region.
Herein,
a
plasmonic
modulation
strategy
nanorods
(GNRs)
through
manganese
dioxide
coating
developed
for
photoacoustic/magnetic
(MR)
duplex‐imaging‐guided
photothermal
chemodynamic
therapy.
GNRs
are
coated
with
silica
(SiO
2
)
then
covered
magnesium
(MnO
obtain
final
product
GNR@SiO
@MnO
(denoted
as
GSM).
The
LSPR
peak
could
be
tuned
by
adjusting
thickness
MnO
layer.
Theoretical
simulations
reveal
that
this
mainly
due
change
refraction
index
around
after
Additionally,
layer
demonstrated
degrade
into
Mn
2+
ions
response
peroxide
acidic
protons
tumor
microenvironment,
which
allows
MR
imaging
This
can
adapted
other
metal
construction
new
class
nanotheranostics.
Nanomaterials,
Journal Year:
2020,
Volume and Issue:
10(4), P. 656 - 656
Published: April 1, 2020
Nanomedicine
is
a
field
of
science
that
uses
nanoscale
materials
for
the
diagnosis
and
treatment
human
disease.
It
has
emerged
as
an
important
aspect
therapeutics,
but
at
same
time,
also
raises
concerns
regarding
safety
nanomaterials
involved.
Recent
applications
functionalized
biodegradable
have
significantly
improved
profile
nanomedicine.
