Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(7)
Published: Nov. 22, 2022
Overcoming
apoptosis
resistance
to
achieve
efficient
breast
cancer
treatment
remains
a
challenge.
The
precise
induction
of
another
form
programmed
cell
death,
pyroptosis,
is
an
excellent
alternative
for
treating
cancer.
Ultrasound
(US)-enhanced
enzyme
dynamic
(enzyodynamic)
therapy
developed
by
employing
LaFeO3
(LFO)
perovskite
nanocrystals
as
substrate
increase
the
rate
deleterious
reactive
oxygen
species
(ROS)
generation
intensive
pyroptosis.
LFO
possess
quadruple
enzyme-mimicking
activities,
including
oxidase-,
peroxidase-,
glutathione
and
catalase-mimicking
which
undertake
dominant
therapeutic
task
through
cascade
catalytic
reactions,
reversal
hypoxic
microenvironment,
depletion
endogenous
glutathione,
continuous
output
ROS.
US
exogenous
stimulation
increases
transition
intermediate
complex
Fe
(II)
favors
incremental
ROS
production,
burst-induced
pyroptosis
process
accomplished
ROS-TXNIP-NLRP3-GSDMD
pathway.
Both
in
vitro
vivo
antineoplastic
outcomes
affirm
ascendancy
nanozyme-induced
This
work
highlights
critical
role
coupled
with
nanocatalytic
reactors
pyroptosis-dominant
circumvention
feature.
Journal of Hematology & Oncology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: Dec. 8, 2022
Abstract
Many
types
of
human
cells
self-destruct
to
maintain
biological
homeostasis
and
defend
the
body
against
pathogenic
substances.
This
process,
called
regulated
cell
death
(RCD),
is
important
for
various
activities,
including
clearance
aberrant
cells.
Thus,
RCD
pathways
represented
by
apoptosis
have
increased
in
importance
as
a
target
development
cancer
medications
recent
years.
However,
because
tumor
show
avoidance
apoptosis,
which
causes
treatment
resistance
recurrence,
numerous
studies
been
devoted
alternative
mortality
processes,
namely
necroptosis,
pyroptosis,
ferroptosis,
cuproptosis;
these
modalities
extensively
studied
shown
be
crucial
therapy
effectiveness.
Furthermore,
evidence
suggests
that
undergoing
may
alter
immunogenicity
microenvironment
(TME)
some
extent,
rendering
it
more
suitable
inhibiting
progression
metastasis.
In
addition,
other
components
TME
undergo
abovementioned
forms
induce
immune
attacks
on
cells,
resulting
enhanced
antitumor
responses.
Hence,
this
review
discusses
molecular
processes
features
cuproptosis
effects
novel
proliferation
Importantly,
introduces
complex
affect
biology.
It
also
summarizes
potential
agents
nanoparticles
or
inhibit
their
therapeutic
based
from
vivo
vitro
reports
clinical
trials
inducers
evaluated
treatments
patients.
Lastly,
we
summarized
impact
modulating
drug
advantages
adding
modulators
over
conventional
treatments.
Small,
Journal Year:
2021,
Volume and Issue:
18(6)
Published: Nov. 2, 2021
Abstract
Chemodynamic
therapy
(CDT),
a
novel
cancer
therapeutic
strategy
defined
as
the
treatment
using
Fenton
or
Fenton‐like
reaction
to
produce
•OH
in
tumor
region,
was
first
proposed
by
Bu,
Shi,
and
co‐workers
2016.
Recently,
with
rapid
development
of
nanomaterials,
CDT
has
attracted
tremendous
attention
because
its
unique
advantages:
1)
It
is
tumor‐selective
low
side
effects;
2)
process
does
not
depend
on
external
field
stimulation;
3)
it
can
modulate
hypoxic
immunosuppressive
microenvironment;
4)
cost
low.
In
addition
Fe‐involved
strategies,
reaction‐mediated
strategies
have
also
been
proposed,
which
are
based
many
other
metal
elements
including
copper,
manganese,
cobalt,
titanium,
vanadium,
palladium,
silver,
molybdenum,
ruthenium,
tungsten,
cerium,
zinc.
Moreover,
combined
therapies
like
chemotherapy,
radiotherapy,
phototherapy,
sonodynamic
therapy,
immunotherapy
for
achieving
enhanced
anticancer
effects.
Besides,
there
studies
that
extend
application
antibacterial
field.
This
review
introduces
latest
advancements
nanomaterials‐involved
from
2018
present
proposes
current
limitations
well
future
research
directions
related
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(48)
Published: Sept. 27, 2021
Chemodynamic
therapy
(CDT)
uses
the
tumor
microenvironment-assisted
intratumoral
Fenton
reaction
for
generating
highly
toxic
hydroxyl
free
radicals
(•OH)
to
achieve
selective
treatment.
However,
limited
efficiency
restricts
therapeutic
efficacy
of
CDT.
Recent
years
have
witnessed
impressive
development
various
strategies
increase
reaction.
The
introduction
these
reinforcement
can
dramatically
improve
treatment
CDT
and
further
promote
enhanced
(ECDT)-based
multimodal
anticancer
treatments.
In
this
review,
authors
systematically
introduce
strategies,
from
their
basic
working
principles,
mechanisms
representative
clinical
applications.
Then,
ECDT-based
is
discussed,
including
how
integrate
emerging
accelerating
therapy,
as
well
synergistic
ECDT
other
methods.
Eventually,
future
direction
challenges
therapies
are
elaborated,
highlighting
key
scientific
problems
unsolved
technical
bottlenecks
facilitate
translation.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(5), P. 8039 - 8068
Published: May 11, 2021
Cancer
cells
frequently
exhibit
resistance
to
various
molecular
and
nanoscale
drugs,
which
inevitably
affects
the
drugs'
therapeutic
outcomes.
Overexpression
of
glutathione
(GSH)
has
been
observed
in
many
cancer
cells,
solid
evidence
corroborated
resulting
tumor
a
variety
anticancer
therapies,
suggesting
that
this
biochemical
characteristic
can
be
developed
as
potential
target
for
treatments.
The
single
treatment
GSH-depleting
agents
potentiate
responses
different
cell
death
stimuli;
therefore,
an
adjunctive
strategy,
GSH
depletion
is
usually
combined
with
mainstream
therapies
enhancing
Propelled
by
rapid
development
nanotechnology,
readily
constructed
into
nanomedicines,
have
shown
steep
rise
over
past
decade.
Here,
we
review
common
nanomedicines
widely
applied
synergistic
treatments
recent
years.
Some
current
challenges
future
perspectives
depletion-based
are
also
presented.
With
understanding
structure–property
relationship
action
mechanisms
these
biomaterials,
hope
nanotechnology
will
further
realize
more
effective
disease
even
achieve
successful
clinical
translations.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Feb. 22, 2022
Nanozyme
is
a
series
of
nanomaterials
with
enzyme-mimetic
activities
that
can
proceed
the
catalytic
reactions
natural
enzymes.
In
field
biomedicine,
nanozymes
are
capturing
tremendous
attention
due
to
their
high
stability
and
low
cost.
Enzyme-mimetic
be
regulated
by
multiple
factors,
such
as
chemical
state
metal
ion,
pH,
hydrogen
peroxide
(H2O2),
glutathione
(GSH)
level,
presenting
great
promise
for
biomedical
applications.
Over
past
decade,
multi-functional
have
been
developed
various
To
promote
understandings
development
novel
multifunctional
nanozymes,
we
herein
provide
comprehensive
review
applications
in
field.
Nanozymes
versatile
enzyme-like
properties
briefly
overviewed,
mechanism
application
discussed
future
research.
Finally,
underlying
challenges
prospects
frontier
this
review.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(43)
Published: Sept. 2, 2022
Abstract
Cuproptosis,
a
newly
identified
form
of
regulated
cell
death
that
is
copper‐dependent,
offers
great
opportunities
for
exploring
the
use
copper‐based
nanomaterials
inducing
cuproptosis
cancer
treatment.
Here,
glucose
oxidase
(GOx)‐engineered
nonporous
copper(I)
1,2,4‐triazolate
([Cu(tz)])
coordination
polymer
(CP)
nanoplatform,
denoted
as
GOx@[Cu(tz)],
starvation‐augmented
and
photodynamic
synergistic
therapy
developed.
Importantly,
catalytic
activity
GOx
shielded
in
scaffold
but
can
be
“turned
on”
efficient
depletion
only
upon
glutathione
(GSH)
stimulation
cells,
thereby
proceeding
starvation
therapy.
The
GSH
sensitizes
cells
to
GOx@[Cu(tz)]‐mediated
cuproptosis,
producing
aggregation
lipoylated
mitochondrial
proteins,
target
copper‐induced
toxicity.
increased
intracellular
hydrogen
peroxide
(H
2
O
)
levels,
due
oxidation
glucose,
activates
type
I
(PDT)
efficacy
GOx@[Cu(tz)].
vivo
experimental
results
indicate
GOx@[Cu(tz)]
produces
negligible
systemic
toxicity
inhibits
tumor
growth
by
92.4%
athymic
mice
bearing
5637
bladder
tumors.
This
thought
first
report
cupreous
nanomaterial
capable
cuproptosis‐based
cancer,
which
should
invigorate
studies
pursuing
rational
design
efficacious
strategies
based
on
cuproptosis.
Journal of Hematology & Oncology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: Sept. 12, 2022
Poor
targeting
of
therapeutics
leading
to
severe
adverse
effects
on
normal
tissues
is
considered
one
the
obstacles
in
cancer
therapy.
To
help
overcome
this,
nanoscale
drug
delivery
systems
have
provided
an
alternative
avenue
for
improving
therapeutic
potential
various
agents
and
bioactive
molecules
through
enhanced
permeability
retention
(EPR)
effect.
Nanosystems
with
cancer-targeted
ligands
can
achieve
effective
tumor
cells
utilizing
cell
surface-specific
receptors,
vasculature
antigens
high
accuracy
affinity.
Additionally,
stimuli-responsive
nanoplatforms
also
been
as
a
promising
strategy
against
tumors,
these
maintain
their
stealth
feature
under
conditions,
but
upon
homing
cancerous
lesions
or
microenvironment,
are
responsive
release
cargoes.
In
this
review,
we
comprehensively
summarize
field
active
number
studies
context
emerging
nanoplatform
development,
discuss
how
knowledge
contribute
further
improvements
clinical
practice.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
34(4)
Published: Oct. 26, 2021
At
present,
some
progress
has
been
made
in
the
field
of
cancer
theranostics
based
on
nanocatalysts
(NCs),
but
achieving
precise
response
to
specific
tumor
microenvironment
(TME)
remains
a
major
challenge.
Herein,
TME-responsive
upconversion
nanoparticles
(UCNPs)-based
smart
UCNPs@Cu-Cys-GOx
(UCCG)
nanosystem
is
engineered,
which
combines
natural
enzymes
and
nanozymes
so
as
amplify
reactive
oxygen
species
(ROS)
generation
situ
for
starvation/chemodynamic/immunotherapy.
One
biggest
merits
this
material
that
it
can
be
preserved
inert
(off)
normal
tissues,
only
TME
specifically
activated
(on)
through
series
enzymatic
cascades
boost
ROS
production
via
strategy
open
source
(H2
O2
self-supplying
ability)
reduce
expenditure
(glutathione
(GSH)
consuming
ability).
More
importantly,
enhanced
oxidative
stress
by
UCCG
NCs
reverses
immunosuppressive
TME,
facilitates
antitumor
immune
responses.
Meanwhile,
starvation/chemodynamic
synergistic
therapy
triggered
combined
with
PD-L1
antibody
effectively
inhibits
growth
primary
tumors
metastasis.
In
addition,
UCNPs
present
luminescence
enhancement,
exploited
visualize
reinforced
real
time.
Collectively,
work
provides
an
original
method
devising
exploitation
UCNPs-based
catalytic
immunotherapy.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(2), P. 2535 - 2545
Published: Jan. 26, 2022
An
urgent
need
in
chemodynamic
therapy
(CDT)
is
to
achieve
high
Fenton
catalytic
efficiency
at
small
doses
of
CDT
agents.
However,
simple
general
promotion
the
reaction
increases
risk
damaging
normal
cells
along
with
cancer
cells.
Therefore,
a
tailored
strategy
selectively
enhance
reactivity
tumors,
for
example,
by
taking
advantage
characteristics
tumor
microenvironment
(TME),
demand.
Herein,
heterogeneous
system
based
on
copper–iron
peroxide
nanoparticles
(CFp
NPs)
designed
TME-mediated
synergistic
therapy.
CFp
NPs
degrade
under
mildly
acidic
conditions
TME,
self-supply
H2O2,
and
released
Cu
Fe
ions,
their
larger
portions
lower
oxidation
states,
cooperatively
facilitate
hydroxyl
radical
production
through
highly
efficient
loop
an
excellent
therapeutic
efficacy.
This
distinct
from
previous
systems
that
synergism
closely
coupled
Cu+-assisted
conversion
Fe3+
Fe2+
rather
than
independent
actions.
As
result,
almost
complete
ablation
tumors
minimal
treatment
dose
demonstrated
without
aid
any
other
modality.
Furthermore,
generate
O2
during
catalysis
exhibit
TME-responsive
T1
magnetic
resonance
imaging
contrast
enhancement,
which
are
useful
alleviating
hypoxia
vivo
monitoring
respectively.
Exploration,
Journal Year:
2022,
Volume and Issue:
2(2)
Published: March 7, 2022
Chemodynamic
therapy
(CDT)
has
emerged
to
be
a
frontrunner
amongst
reactive
oxygen
species-based
cancer
treatment
modalities.
CDT
utilizes
endogenous
H