Theranostics,
Journal Year:
2023,
Volume and Issue:
13(6), P. 1974 - 2014
Published: Jan. 1, 2023
Chemodynamic
therapy
(CDT)
is
well-known
for
using
the
tumor
microenvironment
to
activate
Fenton
reaction
or
Fenton-like
generate
strong
oxidative
hydroxyl
radicals
tumor-specific
treatment.
It
highly
selective
and
safe,
without
depth
limitation
of
tissue
penetration,
shows
its
potential
as
a
new
green
therapeutic
method
with
great
clinical
application.
However,
catalytic
efficiency
reagents
involved
in
severely
affected
by
inherent
microenvironmental
limitations
tumors
strict
reaction-dependent
conditions.
With
increasing
application
nanotechnology
medical
field,
combined
therapies
based
on
different
types
functional
nanomaterials
have
opened
up
avenues
development
next-generation
CDT-enhanced
system.
This
review
will
comprehensively
exemplify
representative
results
CDT
other
antitumor
such
chemotherapy,
phototherapy,
sonodynamic
therapy,
radiation
magnetic
hyperthermia
immunotherapy,
starvation
gas
gene
oncosis
combination
thereof
improving
from
hundreds
latest
literature,
introduce
strategies
ingenious
design
nanomedicines
regulations
enhance
further
summarize
challenges
future
perspective
CDT-based
multimodal
anticancer
therapy.
Chemical Reviews,
Journal Year:
2019,
Volume and Issue:
119(8), P. 4881 - 4985
Published: April 11, 2019
Reactive
oxygen
species
(ROS)
play
an
essential
role
in
regulating
various
physiological
functions
of
living
organisms.
The
intrinsic
biochemical
properties
ROS,
which
underlie
the
mechanisms
necessary
for
growth,
fitness,
or
aging
organisms,
have
been
driving
researchers
to
take
full
advantage
these
active
chemical
contributing
medical
advances.
Thanks
remarkable
advances
nanotechnology,
great
varieties
nanomaterials
with
unique
ROS-regulating
explored
guide
temporospatial
dynamic
behaviors
ROS
biological
milieu,
contributes
emergence
a
new-generation
therapeutic
methodology,
i.e.,
nanomaterial-guided
vivo
evolution
therapy.
interdependent
relationship
between
and
their
corresponding
chemistry,
biology,
nanotherapy
leads
us
propose
concept
"ROS
science",
is
believed
be
emerging
scientific
discipline
that
studies
mechanisms,
effects,
nanotherapeutic
applications
ROS.
In
this
review,
state-of-art
concerning
recent
progresses
on
ROS-based
nanotherapies
summarized
detail,
emphasis
underlying
material
chemistry
by
are
generated
scavenged
improved
outcomes.
Furthermore,
key
issues
cross-disciplinary
fields
also
discussed,
aiming
unlock
innate
powers
optimized
efficacies.
We
expect
our
demonstration
evolving
field
will
beneficial
further
development
fundamental
researches
clinical
applications.
Chemical Society Reviews,
Journal Year:
2016,
Volume and Issue:
45(5), P. 1457 - 1501
Published: Jan. 1, 2016
New
achievements
in
the
realm
of
nanoscience
and
innovative
techniques
nanomedicine
have
moved
micro/nanoparticles
(MNPs)
to
point
becoming
actually
useful
for
practical
applications
near
future.
Saudi Pharmaceutical Journal,
Journal Year:
2017,
Volume and Issue:
26(1), P. 64 - 70
Published: Oct. 25, 2017
The
development
of
nanoparticle-based
drug
formulations
has
yielded
the
opportunities
to
address
and
treat
challenging
diseases.
Nanoparticles
vary
in
size
but
are
generally
ranging
from
100
500
nm.
Through
manipulation
size,
surface
characteristics
material
used,
nanoparticles
can
be
developed
into
smart
systems,
encasing
therapeutic
imaging
agents
as
well
bearing
stealth
property.
Further,
these
systems
deliver
specific
tissues
provide
controlled
release
therapy.
This
targeted
sustained
delivery
decreases
related
toxicity
increase
patient's
compliance
with
less
frequent
dosing.
Nanotechnology
proven
beneficial
treatment
cancer,
AIDS
many
other
disease,
also
providing
advancement
diagnostic
testing.
Toxics,
Journal Year:
2017,
Volume and Issue:
5(4), P. 29 - 29
Published: Oct. 17, 2017
The
development
of
different
kinds
nanoparticles,
showing
physico-chemical
properties,
has
fostered
their
large
use
in
many
fields,
including
medicine.
As
a
consequence,
inorganic
nanoparticles
(e.g.,
metals
or
semiconductors),
have
raised
issues
about
potential
toxicity.
scientific
community
is
investigating
the
toxicity
mechanisms
these
materials,
vitro
and
vivo,
order
to
provide
accurate
references
concerning
use.
This
review
will
give
readers
thorough
exploration
on
entry
human
body,
such
as
titanium
dioxide
(TiO2NPs),
silicon
(SiO2NPs),
zinc
oxide
(ZnONPs),
silver
(AgNPs),
gold
(AuNPs)
quantum
dots
(QDsNPs).
In
addition,
biodistribution,
current
trends
novelties
vivo
toxicology
studies
be
discussed,
with
particular
focus
immune
response.
ACS Applied Materials & Interfaces,
Journal Year:
2015,
Volume and Issue:
7(37), P. 20568 - 20575
Published: Sept. 14, 2015
The
interaction
at
nanobio
is
a
critical
issue
in
designing
safe
nanomaterials
for
biomedical
applications.
Recent
studies
have
reported
that
it
nanoparticle–protein
corona
rather
than
bare
nanoparticle
determines
the
nanoparticle–cell
interactions,
including
endocytic
pathway
and
biological
responses.
Here,
we
demonstrate
effects
of
protein
on
cellular
uptake
different
sized
gold
nanoparticles
cell
lines.
experimental
results
show
significantly
decreases
internalization
Au
NPs
particle
size-
type-dependent
manner.
Protein
exhibits
much
more
significant
inhibition
large-sized
by
phagocytic
small-sized
nonphagocytic
cell.
endocytosis
experiment
indicates
pathways
might
be
responsible
differential
roles
with
Our
findings
can
provide
useful
information
rational
design
application.
