Bactericidal and Cytotoxic Properties of Silver Nanoparticles

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(2), P. 449 - 449

Published: Jan. 21, 2019

Silver nanoparticles (AgNPs) can be synthesized from a variety of techniques including physical, chemical and biological routes. They have been widely used as nanomaterials for manufacturing cosmetic healthcare products, antimicrobial textiles, wound dressings, antitumor drug carriers, etc. due to their excellent properties. Accordingly, AgNPs gained access into our daily life, the inevitable human exposure these has raised concerns about potential hazards environment, health, safety in recent years. From vitro cell cultivation tests, reported toxic several lines bronchial epithelial cells, umbilical vein endothelial red blood peripheral mononuclear immortal keratinocytes, liver induce dose-, size- time-dependent cytotoxicity, particularly those with sizes ≤10 nm. Furthermore, cross brain barrier mice through circulation system on basis vivo animal tests. tend accumulate organs such liver, spleen, kidney following intravenous, intraperitoneal, intratracheal routes administration. In this respect, are considered double-edged sword that eliminate microorganisms but cytotoxicity mammalian cells. This article provides state-of-the-art review synthesis AgNPs, applications textile fabrics, food packaging films, dressings. Particular attention is paid bactericidal activity cytotoxic effect

Language: Английский

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Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(7), P. 2375 - 2375

Published: March 30, 2020

Engineered nanomaterials (ENMs) have gained huge importance in technological advancements over the past few years. Among various ENMs, silver nanoparticles (AgNPs) become one of most explored nanotechnology-derived nanostructures and been intensively investigated for their unique physicochemical properties. The widespread commercial biomedical application nanosilver include its use as a catalyst an optical receptor cosmetics, electronics textile engineering, bactericidal agent, wound dressings, surgical instruments, disinfectants. This, turn, has increased potential interactions AgNPs with terrestrial aquatic environments, well exposure toxicity to human health. In present review, after giving overview we discuss current advances on physiochemical properties specific emphasis biodistribution both vitro vivo following routes exposure. Most studies demonstrated size-, dose- coating-dependent cellular uptake AgNPs. Following NPs exposure, reported Ag accumulation local distant organs. Though there increase number this area, more investigations are required understand mechanisms modes

Language: Английский

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Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

Frontiers in Microbiology, Journal Year: 2018, Volume and Issue: 9

Published: July 2, 2018

Infectious diseases remain one of the leading causes morbidity and mortality worldwide. The WHO CDC have expressed serious concern regarding continued increase in development multidrug resistance among bacteria. Therefore, antibiotic crisis is most pressing issues global public health. Associated with rise lack new antimicrobials. This has triggered initiatives worldwide to develop novel more effective antimicrobial compounds as well delivery targeting strategies. Bacteria developed many ways by which they become resistant Among those are enzyme inactivation, decreased cell permeability, target protection, overproduction, altered site/enzyme, increased efflux due over-expression pumps, others. Other complex phenotypes, such biofilm formation quorum sensing do not appear a result exposure bacteria antibiotics although, it known that can be induced antibiotics. These phenotypes related tolerance Different strategies, use nanostructured materials, being overcome these other types resistance. Nanostructured materials used convey antimicrobials, assist drugs or ultimately, possess activity themselves. Additionally, nanoparticles (e.g., metallic, organic, carbon nanotubes, etc.) may circumvent drug mechanisms and, associated their potential, inhibit important processes. including combined plant-based antimicrobials toxicity issues, also investigated. Coupling natural-based (or repurposed compounds) bacterial pumps; biofilms; interference sensing; possibly plasmid curing, just some strategies combat However, still presents challenge therapy much research needed order this. In this review, we will summarize current on nanomaterials how applied future fight

Language: Английский

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Multifunctional biomolecule nanostructures for cancer therapy

Nature Reviews Materials, Journal Year: 2021, Volume and Issue: 6(9), P. 766 - 783

Published: May 19, 2021

Language: Английский

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Green approaches in synthesising nanomaterials for environmental nanobioremediation: Technological advancements, applications, benefits and challenges

Environmental Research, Journal Year: 2021, Volume and Issue: 204, P. 111967 - 111967

Published: Aug. 25, 2021

Language: Английский

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Nanoparticles' interactions with vasculature in diseases

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(21), P. 5381 - 5407

Published: Jan. 1, 2019

The ever-growing use of inorganic nanoparticles (NPs) in biomedicine provides an exciting approach to develop novel imaging and drug delivery systems, owing the ease with which these NPs can be functionalized cater various applications. In cancer therapeutics, nanomedicine generally relies on enhanced permeability retention (EPR) effect observed tumour vasculature deliver anti-cancer drugs across endothelium. However, such a phenomenon is dependent microenvironment not consistently all types, thereby limiting transport site. On other hand, there rise utilizing intentionally induce endothelial leakiness, creating window opportunity control While this active targeting creates similar compared EPR arising from tissues, its applications extend beyond therapeutics into vascular-related diseases. review, we summarize current findings assess limitations context systems. offers possible route for passage, further explore alternative uses create controllable leakiness within short exposures, coined as nanomaterial-induced (NanoEL). Furthermore, discuss main mechanistic features NanoEL that make it unique conventionally established homeostatic pathologic conditions, well examine potential applicability diseases, particularly cancer. Therefore, new paradigm changes way are currently being used biomedical

Language: Английский

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Nanomaterials in the environment, human exposure pathway, and health effects: A review

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 759, P. 143470 - 143470

Published: Nov. 17, 2020

Language: Английский

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Repeated-oral dose toxicity of polyethylene microplastics and the possible implications on reproduction and development of the next generation

Toxicology Letters, Journal Year: 2020, Volume and Issue: 324, P. 75 - 85

Published: Jan. 16, 2020

Language: Английский

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The Chemistry of Organic Contrast Agents in the NIR‐II Window

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(14)

Published: Dec. 7, 2021

Abstract Optical imaging, especially fluorescence and photoacoustic is a non‐invasive imaging approach with high spatial temporal resolution sensitivity, compared to positron emission tomography (PET) or magnetic resonance (MRI). Due the merits of using second near‐infrared (NIR‐II) window, like deeper penetration depth, signal‐to‐noise ratio, resolution, low tissue damage, researchers have devoted great effort developing contrast agents NIR‐II absorption emission. In this Review, we summarize recently developed organic luminescent materials, ranging from small molecules conjugated polymers. Then, systematically introduce engineering strategies describe performance classified by skeleton cores. Finally, elucidate challenges prospects these dyes for potential clinical applications. We expect our summary can inspire expand spectrum diverse bioapplications.

Language: Английский

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Impact of Nanoparticles on Brain Health: An Up to Date Overview

Journal of Clinical Medicine, Journal Year: 2018, Volume and Issue: 7(12), P. 490 - 490

Published: Nov. 27, 2018

Nanoparticles are zero-dimensional nanomaterials and, based on their nature, they can be categorized into organic, inorganic, and composites nanoparticles. Due to unique physical chemical properties, nanoparticles extensively used in a variety of fields, including medicine, pharmaceutics, food industry. Although have the potential improve diagnosis treatment brain diseases, it is fundamentally important develop standardized toxicological studies, which prevent induction neurotoxic effects. The focus this review emphasize both beneficial negative effects health.

Language: Английский

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