An Integrated Fluorescent Probe for Ratiometric Detection of Glutathione in the Golgi Apparatus and Activated Organelle-Targeted Therapy DOI

Xiaodi Rong,

Caiyun Liu, Mingzhu Li

et al.

Analytical Chemistry, Journal Year: 2021, Volume and Issue: 93(48), P. 16105 - 16112

Published: Nov. 19, 2021

Cancer is a serious threat to human health, and there an urgent need develop new treatment methods overcome it. Organelle targeting therapy, as highly effective less toxic side effect strategy, has great research significance development prospects. Being essential organelle, the Golgi apparatus plays particularly major role in growth of cancer cells. Acting indispensable expressed antioxidant cells, glutathione (GSH) also contributes greatly during oxidative stress. Therefore, it counts for much track changes GSH concentration monitoring occurrence tumor exploring Golgi-targeted therapy extremely important cancer. In this work, we designed synthesized simple Golgi-targeting fluorescent probe GT-GSH accurately detecting GSH. The reacting with decomposes substances Golgi, thereby killing At same time, ratiometric can detect stress high sensitivity selectivity living such GSH-responsive gives method accurate

Language: Английский

Recent advances in multifunctional fluorescent probes for viscosity and analytes DOI
Xiaopeng Yang, Di Zhang, Yong Ye

et al.

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 453, P. 214336 - 214336

Published: Dec. 4, 2021

Language: Английский

Citations

238

High-performance near-infrared fluorescence probe for fast and specific visualization of harmful sulfite in food, living cells, and zebrafish DOI
Lirong Jiang, Tianhong Chen,

Erwang Song

et al.

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 427, P. 131563 - 131563

Published: Aug. 8, 2021

Language: Английский

Citations

176

Fluorescent Probes for Disease Diagnosis DOI Creative Commons
Xin Wang, Qi Ding, Robin R. Groleau

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(11), P. 7106 - 7164

Published: May 17, 2024

The identification and detection of disease-related biomarkers is essential for early clinical diagnosis, evaluating disease progression, the development therapeutics. Possessing advantages high sensitivity selectivity, fluorescent probes have become effective tools monitoring active molecules at cellular level in vivo. In this review, we describe current designed quantification key bioactive associated with common diseases, such as organ damage, inflammation, cancers, cardiovascular brain disorders. We emphasize strategies behind design capable biomarker diagnosis cover some aspects combined diagnostic/therapeutic based on regulating molecules. This review concludes a discussion challenges outlook probes, highlighting future avenues research that should enable these to achieve accurate biomedical applications.

Language: Английский

Citations

105

A review: Small organic molecule dual/multi-organelle-targeted fluorescent probes DOI
Yongfei Huang, Junping Liang, Zhefeng Fan

et al.

Talanta, Journal Year: 2023, Volume and Issue: 259, P. 124529 - 124529

Published: April 7, 2023

Language: Английский

Citations

58

A Space‐Dependent ‘Enzyme‐Substrate’ Type Probe based on ‘Carboxylesterase‐Amide Group’ for Ultrafast Fluorescent Imaging Orthotopic Hepatocellular Carcinoma DOI Creative Commons
Ying Wen, Jing Ning, Min Zhang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(8)

Published: Jan. 18, 2023

Abstract Fast and selective fluorescence imaging for a biomarker to related‐disease diagnosis remains significant challenge due complex physical environment. Human carboxylesterase (CE) is expected be potential of hepatocellular carcinoma (HCC) improve the accuracy diagnosis. However, existing probes CE has slow response rate low selectivity. Herein, amide group selected as CE‐responsive sites based on “substrate‐hydrolysis enzymatic reaction” approach. From series off–on with leave groups in unit, probe J screened optimal combination rapid high selectivity toward CE. requires only 150 s reach maximum at 676 nm presence free from interference other esterase. Computational docking simulations indicate shortest distance between active site . Cell vivo present that can turn liver cancer cells tumor region precisely. Importantly, allowed specifically image orthotopic rather than metastatic distinguish human primary tissue adjacent ones. This study provides new tool detection promotes advancements accurate HCC

Language: Английский

Citations

45

Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine DOI Creative Commons
Yanhong Duo, Lei Han, Yaoqiang Yang

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(20), P. 11242 - 11347

Published: Oct. 9, 2024

Biopsy, including tissue and liquid biopsy, offers comprehensive real-time physiological pathological information for disease detection, diagnosis, monitoring. Fluorescent probes are frequently selected to obtain adequate on processes in a rapid minimally invasive manner based their advantages biopsy. However, conventional fluorescent have been found show aggregation-caused quenching (ACQ) properties, impeding greater progresses this area. Since the discovery of aggregation-induced emission luminogen (AIEgen) promoted advancements molecular bionanomaterials owing unique high quantum yield (QY) signal-to-noise ratio (SNR),

Language: Английский

Citations

22

Multi-Signal Fluorescent Probe for Simultaneous Differentiation and Imaging of Hg2+, Cys, Hcy, and GSH in Living Cells and Zebrafish DOI
Yang Li, Jing Li, Ting Yu

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137427 - 137427

Published: Jan. 1, 2025

Language: Английский

Citations

4

The chronological evolution of small organic molecular fluorescent probes for thiols DOI Creative Commons
Yongkang Yue, Fangjun Huo, Caixia Yin

et al.

Chemical Science, Journal Year: 2020, Volume and Issue: 12(4), P. 1220 - 1226

Published: Dec. 15, 2020

The chronological evolution of small organic molecular fluorescent probes for thiols: from separation dependency analysis to cellular specific analysis, what's next?

Language: Английский

Citations

110

Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents DOI Creative Commons
Chenxu Yan,

Zhiqian Guo,

Weijie Chi

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: June 23, 2021

Abstract Intramolecular charge transfer (ICT) is a fundamental mechanism that enables the development of numerous fluorophores and probes for bioimaging sensing. However, electron-withdrawing targets (EWTs)-induced fluorescence quenching long-standing unsolved issue in ICT fluorophores, significantly limits widespread applicability. Here we report simple generalizable structural-modification completely overturning intramolecular rotation driving energy, thus fully reversing fluorophores’ mode into light-up mode. Specifically, insertion an indazole unit scaffold can amplify donor-indazole-π-acceptor (fluorescence OFF), whereas efficiently suppressing their EWT-substituted system ON). This molecular strategy generalizable, yielding palette chromophores with umpolung spans visible near-infrared range. expands bio-analytical toolboxes allows exploiting sensing EWTs including N -acetyltransferases nerve agents.

Language: Английский

Citations

86

A dual-targeted organelles SO2 specific probe for bioimaging in related diseases and food analysis DOI
Yongfei Huang,

Yongbin Zhang,

Fangjun Huo

et al.

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 433, P. 133750 - 133750

Published: Nov. 23, 2021

Language: Английский

Citations

77