Ru(II)-modified TiO2 nanoparticles for hypoxia-adaptive photo-immunotherapy of oral squamous cell carcinoma DOI Creative Commons
Jiaying Zhou, Wenjin Wang, Chenyu Zhang

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 289, P. 121757 - 121757

Published: Aug. 24, 2022

The alternations in the hypoxic and immune microenvironment are closely related to therapeutic effect prognosis of oral squamous cell carcinoma (OSCC). Herein, a new nanocomposite, TiO2@[email protected] is constructed from ruthenium-based photosensitizer (Ru) modified-TiO2 nanoparticles (NPs) loaded with siRNA hypoxia-inducible factor-1α (HIF-1α). Under visible light irradiation, can elicit both Type I II photodynamic effects, which causes lysosomal damage, HIF-1α gene silencing, OSCC elimination efficiently. As consequence hypoxia relief pyroptosis induction, reshapes by downregulation key immunosuppressive factors, upregulation cytokines, activation CD4+ CD8+ T lymphocytes. Furthermore, patient-derived xenograft (PDX) rat experimental carcinogenesis models prove that protected]-mediated therapy significantly inhibits tumor growth progression, markedly enhances cancer immunity. In all, this study presents an effective hypoxia-adaptive photo-immunotherapeutic nanosystem great potential for prevention treatment.

Language: Английский

Oxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy DOI Creative Commons
Yufu Tang, Yuanyuan Li, Bowen Li

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 21, 2024

Abstract Photodynamic therapy (PDT) is a promising cancer treatment but has limitations due to its dependence on oxygen and high-power-density photoexcitation. Here, we report polymer-based organic photosensitizers (PSs) through rational PS skeleton design precise side-chain engineering generate •O 2 − •OH under oxygen-free conditions using ultralow-power 808 nm photoexcitation for tumor-specific photodynamic ablation. The designed skeletons can electron-hole pairs sensitize H O into with photoexcitation, achieving NIR-photoexcited oxygen-independent production. Further, compared commonly used alkyl side chains, glycol oligomer as the chain mitigates recombination offers more molecules around generated from hydrophobic skeletons, which yield 4-fold stronger production, thus allowing an high PDT effect. Finally, feasibility of developing activatable PSs in female mice further demonstrated irradiation 15 mW cm −2 . study not only provides insights mechanism also general guideline develop NIR PDT.

Language: Английский

Citations

69
A Cascade Strategy Boosting Hydroxyl Radical Generation with Aggregation-Induced Emission Photosensitizers-Albumin Complex for Photodynamic Therapy DOI
Yulu Li, Di Zhang, Yuewen Yu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(17), P. 16993 - 17003

Published: Aug. 22, 2023

Effective photodynamic therapy (PDT) requires photosensitizers (PSs) to massively generate type I reactive oxygen species (ROS) in a less oxygen-dependent manner the hypoxia tumor microenvironment. Herein, we present cascade strategy boost ROS, especially hydroxyl radical (OH·-), generation with an aggregation-induced emission (AIE) photosensitizer-albumin complex for hypoxia-tolerant PDT. The cationic AIE PS TPAQ-Py-PF6 (TPA = triphenylamine, Q anthraquinone, Py pyridine) contains three important moieties cooperatively enhance free generation: AIE-active TPA unit ensures effective triplet exciton aggregate, anthraquinone moiety possesses redox cycling ability promote electron transfer, while methylpyridinium cation further increases intramolecular charge transfer and separation processes. Inserting into hydrophobic domain of bovine serum albumin nanoparticles (BSA NPs) could greatly immobilize its molecular geometry increase generation, electron-rich microenvironment BSA ultimately leads OH·- generation. Both experimental theoretical results confirm effectiveness our cationization immobilization enhancing In vitro vivo experiments validate excellent antitumor PDT performance NPs, superior conventional polymeric encapsulation approach. Such multidimensional specially boosting shall hold great potential related applications.

Language: Английский

Citations

64
Recent advances in type I organic photosensitizers for efficient photodynamic therapy for overcoming tumor hypoxia DOI
Bingli Lu, Lingyun Wang, Hao Tang

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(21), P. 4600 - 4618

Published: Jan. 1, 2023

Photodynamic therapy (PDT) with an oxygen-dependent character is a noninvasive therapeutic method for cancer treatment.

Language: Английский

Citations

63
Recent Advances and Clinical Potential of Near Infrared Photothermal Conversion Materials for Photothermal Hepatocellular Carcinoma Therapy DOI
Ruiliang Ge,

Pei-ning Yan,

Yang Liu

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(29)

Published: June 9, 2023

Abstract Growing concern about photothermal tumor therapy (PTT) as a promising alternative to conventional liver cancer treatment, which is treatment strategy that utilizes near‐infrared (NIR) light‐induced agents (PTAs) yield effects localize thermal damage for tumors. Herein, given the gap between experimental research and clinical application, this review seeks timely summarize highlight recent progress of PTAs used in vivo vitro last five‐year. The implications various on multifunctional conversion capability, structure‐performance correlations PTT, together with evaluation their potential application are systematically dissected further dig out what buried mechanism is. Besides, higher requirements put forward discrepancies crucial issues faced by different PTT related medical technical obstacles being conquered, lays solid theoretical foundation field oncology whole, especially cancer. Finally, it expected can present valuable guidance design efficient, photostability, biosafety‐aware anticancer while stepping into fast traffic lane from bench bedside foreseeable future.

Language: Английский

Citations

61
Recent advances and prospects in organic molecule-based phototheranostic agents for enhanced cancer phototherapy DOI
Yuanyuan Zhao, Heejeong Kim, Nguyễn Văn Nghĩa

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215560 - 215560

Published: Nov. 27, 2023

Language: Английский

Citations

60
A Metal‐Free Mesoporous Carbon Dots/Silica Hybrid Type I Photosensitizer with Enzyme‐Activity for Synergistic Treatment of Hypoxic Tumor DOI
Boshi Tian, Shaohua Liu, Chenghao Yu

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(25)

Published: March 10, 2023

Abstract As a less O 2 ‐dependent photodynamic therapy (PDT), type I PDT is an effective approach to overcome the hypoxia‐induced low efficiency against solid tumors. However, commonly used metal‐involved agents suffer from long‐term biosafety concern. Herein, metal‐free photosensitizer, N ‐doped carbon dots/mesoporous silica nanoparticles (NCDs/MSN, ≈40 nm) nanohybrid with peroxidase (POD)‐like activity for synergistic and enzyme‐activity treatment, developed on gram scale via facile one‐pot strategy through mixing source precursor assistance of template. Benefiting narrow bandgap (1.92 eV) good charge separation capacity NCDs/MSN, upon 640 nm light irradiation, excited electrons in conduction band can effectively generate •− by reduction dissolved one‐electron transfer process even under hypoxic conditions, inducing apoptosis tumor cells. Moreover, photoinduced partially transform into more toxic • OH two‐electron reduction. POD‐like NCDs/MSN catalyze endogenous H microenvironment, further synergistically ablating 4T1 Therefore, mass production way synthesize novel photosensitizer enzyme‐mimic treatment tumors provided, which exhibits promising clinical translation prospects.

Language: Английский

Citations

57
Innovative strategies for photodynamic therapy against hypoxic tumor DOI Creative Commons
Xiaotong Li, Lei Chen,

Miaoting Huang

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(1), P. 100775 - 100775

Published: Jan. 1, 2023

Photodynamic therapy (PDT) is applied as a robust therapeutic option for tumor, which exhibits some advantages of unique selectivity and irreversible damage to tumor cells. Among which, photosensitizer (PS), appropriate laser irradiation oxygen (O2) are three essential components PDT, but the hypoxic microenvironment (TME) restricts O2 supply in tissues. Even worse, metastasis drug resistance frequently happen under condition, further deteriorate antitumor effect PDT. To enhance PDT efficiency, critical attention has been received by relieving hypoxia, innovative strategies on this topic continue emerge. Traditionally, supplement strategy considered direct effective relieve TME, whereas it confronted with great challenges continuous supply. Recently, O2-independent provides brand new can avoid influence TME. In addition, synergize other strategies, such chemotherapy, immunotherapy, photothermal (PTT) starvation therapy, remedy inadequate hypoxia conditions. paper, we summarized latest progresses development improve efficacy against were classified into O2-dependent synergistic therapy. Furthermore, deficiencies various also discussed envisage prospects future study.

Language: Английский

Citations

56
Supramolecular systems for bioapplications: recent research progress in China DOI
Yue‐Yang Liu, Xiao-Yong Yu, Yu‐Chen Pan

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 1397 - 1441

Published: March 22, 2024

Language: Английский

Citations

31
Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy DOI Creative Commons
Hai Xu, Dahee Kim, Yuanyuan Zhao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: March 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Language: Английский

Citations

27
A Renal Clearable Nano‐Assembly with Förster Resonance Energy Transfer Amplified Superoxide Radical and Heat Generation to Overcome Hypoxia Resistance in Phototherapeutics DOI Creative Commons
Yuanyuan Zhao, Xiaojun Zhang, Yihui Xu

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(44)

Published: June 28, 2024

Abstract Given that type I photosensitizers (PSs) possess a good hypoxic tolerance, developing an innovative tactic to construct PSs is crucially important, but remains challenge. Herein, we present smart molecular design strategy based on the Förster resonance energy transfer (FRET) mechanism develop photodynamic therapy (PDT) agent with encouraging amplification effect for accurate tumor therapy. Of note, benefiting from FRET effect, obtained nanostructured PDT (NanoPcSZ) boosted light‐harvesting ability not only amplifies superoxide radical (O 2 •‐ ) production also promotes heat generation upon near‐infrared light irradiation. These features facilitate NanoPcSZ realize excellent phototherapeutic response under both normal and environments. As result, in vitro vivo experiments achieved remarkable improvement therapeutic efficacy via combined of photothermal action photoreaction. Notably, can be eliminated organs (including liver, lung, spleen, kidney) apart site excreted through urine within 24 h its systemic administration. In this way, potential biotoxicity drug accumulation avoided biosafety further enhanced.

Language: Английский

Citations

25