In vivo NIR-II fluorescence imaging for biology and medicine

Nature Photonics, Journal Year: 2024, Volume and Issue: 18(6), P. 535 - 547

Published: March 4, 2024

Language: Английский

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Near infrared fluorescent probes for detecting and imaging active small molecules

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 482, P. 215080 - 215080

Published: Feb. 21, 2023

Language: Английский

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Mitochondria-targeted BODIPY dyes for small molecule recognition, bio-imaging and photodynamic therapy

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(8), P. 3976 - 4019

Published: Jan. 1, 2024

This review focuses on the design strategy, spectroscopic characteristics, and functionalization of mitochondrion-targeted BODIPY dyes, providing an overview these dyes for bioimaging photodynamic therapy.

Language: Английский

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Doubly Strapped Zwitterionic NIR‐I and NIR‐II Heptamethine Cyanine Dyes for Bioconjugation and Fluorescence Imaging

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(28)

Published: May 11, 2023

Heptamethine cyanine dyes enable deep tissue fluorescence imaging in the near infrared (NIR) window. Small molecule conjugates of benchmark dye ZW800-1 have been tested humans. However, long-term protocols using are limited by their instability, primarily because chemically labile C4'-O-aryl linker is susceptible to cleavage biological nucleophiles. Here, we report a modular synthetic method that produces novel doubly strapped zwitterionic heptamethine dyes, including structural analogue ZW800-1, with greatly enhanced stability. NIR-I and NIR-II versions these can be conjugated proteins, monoclonal antibodies, without causing undesired fluorophore degradation or stacking on protein surface. The fluorescent antibody show excellent tumor-targeting specificity xenograft mouse tumor model. stability provided molecular design will new classes vivo NIR experiments possible translation

Language: Английский

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Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 505, P. 215677 - 215677

Published: Jan. 31, 2024

Language: Английский

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Recent advances in NIR-II fluorescence/photoacoustic dual-modality imaging probes

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 514, P. 215907 - 215907

Published: May 12, 2024

Language: Английский

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Development of Polymethine Dyes for NIR‐II Fluorescence Imaging and Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)

Published: March 5, 2024

Fluorescence imaging in the second near-infrared window (NIR-II) is burgeoning because of its higher fidelity monitoring physiological and pathological processes than clinical visible/the fluorescence imaging. Notably, heavily dependent on agents. So far, indocyanine green, one polymethine dyes, with good biocompatibility renal clearance only dye approved by Food Drug Administration, but it shows relatively low NIR-II brightness. Importantly, tremendous efforts are devoted to synthesizing dyes for preclinically clinically. They have shown feasibility customization structure properties fulfill various needs therapy. Herein, a timely update special focus molecular design strategies fluorescent, photoacoustic, multimodal imaging, offered. Furthermore, progress sensing biomarkers even reporting drug release illustrated. Moreover, imaging-guided therapies summarized regarding chemo-, photothermal, photodynamic, approaches. In addition, artificial intelligence pointed out potential expedite development. This comprehensive review will inspire interest among wide audience offer handbook people an dyes.

Language: Английский

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Rational Design of NIR‐II Ratiometric Fluorescence Probes for Accurate Bioimaging and Biosensing In Vivo

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: March 12, 2024

Abstract Intravital fluorescence imaging in the second near‐infrared window (NIR‐II, 900–1700 nm) has emerged as a promising method for non‐invasive diagnostics complex biological systems due to its advantages of less background interference, high tissue penetration depth, contrast, and sensitivity. However, traditional NIR‐II imaging, which is characterized by “always on” or “turn mode, lacks ability quantitative detection, leading low reproducibility reliability during bio‐detection. In ratiometric can realize reliable analysis detection vivo providing reference signals correction, generating new opportunities prospects bioimaging biosensing. this review, current design strategies sensing mechanisms probes biosensing applications are systematically summarized. Further, challenges, future perspectives designing also discussed. It hoped that review provide effective guidance promote adoption vivo.

Language: Английский

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Near-Infrared Fluorescence Probe with a New Recognition Moiety for the Specific Detection of Cysteine to Study the Corresponding Physiological Processes in Cells, Zebrafish, and Arabidopsis thaliana

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(15), P. 6030 - 6036

Published: April 3, 2024

Cysteine (Cys), as one of the biological thiols, is related to many physiological and pathological processes in humans plants. Therefore, it necessary develop a sensitive selective method for detection imaging Cys organisms. In this work, novel near-infrared (NIR) fluorescent probe, Probe-Cys, was designed by connecting furancarbonyl, new recognition moiety, with Fluorophore–OH via decomposition IR-806. The use furan moiety anticipated produce more effective fluorescence quenching because electron-donating ability O atom. Probe-Cys has outstanding properties, such group, an emission wavelength infrared region at 710 nm, linear range (0–100 μM), low limit 0.035 μM, good water solubility, excellent sensitivity, selectivity without interference Hcy, GSH, HS–. More importantly, could achieve endogenous reacting stimulant 1,4-dimercaptothreitol (DTT) inhibitor N-ethylmaleimide (NEM) HepG2 cells zebrafish. Ultimately, successfully applied obtain images Arabidopsis thaliana, revealing that content meristematic zone higher than elongation zone, which first time NIR probe used A. thaliana. superior properties exhibit its great potential biosystems explore associated Cys.

Language: Английский

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Advances in Organic Small Molecule-Based Fluorescent Probes for Precision Detection of Liver Diseases: A Perspective on Emerging Trends and Challenges

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Liver disease poses a significant challenge to global health, and its early diagnosis is crucial for improving treatment outcomes patient prognosis. Since fluctuation of key biomarkers during the onset progression liver diseases can directly reflect health normal/abnormal function, biomarker-based assays are vital tools detection disease. In this context, small molecule fluorescent probes have undeniably emerged as indispensable analysis, with an ever-growing number molecule-based being developed over recent years, sole aim monitoring relevant This perspective will focus on development application primarily last 10 years diagnosing range disease-related processes. It outline foundational design strategies developing promising probes, their optical response biomarkers, how they been demonstrated in proof-of-concept imaging applications. Current challenges new developments field be discussed, providing insights highlighting opportunities field.

Language: Английский

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