NIR-II light in clinical oncology: opportunities and challenges

Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: 21(6), P. 449 - 467

Published: May 1, 2024

Language: Английский

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Near-infrared II fluorescence imaging

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: April 4, 2024

Language: Английский

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Small molecular cyanine dyes for phototheranostics

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 516, P. 215986 - 215986

Published: June 2, 2024

Language: Английский

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High-brightness transition metal-sensitized lanthanide near-infrared luminescent nanoparticles

Nature Photonics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Language: Английский

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Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

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An Emerging Toolkit of Ho³⁺ Sensitized Lanthanide Nanocrystals with NIR-II Excitation and Emission for in Vivo Bioimaging

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Optical imaging in the second near-infrared window (NIR-II, 1000-1700 nm) holds great promise for biomedical detection due to reduced tissue scattering and autofluorescence. However, rational design of NIR-II probes with superior excitation wavelengths balance effects water absorption remains a challenge. To address this issue, here we developed series Ho

Language: Английский

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Aggregation-Induced Emission Luminogens Realizing High-Contrast Bioimaging

ACS Nano, Journal Year: 2025, Volume and Issue: 19(1), P. 281 - 306

Published: Jan. 2, 2025

A revolutionary transformation in biomedical imaging is unfolding with the advent of aggregation-induced emission luminogens (AIEgens). These cutting-edge molecules not only overcome limitations traditional fluorescent probes but also improve boundaries high-contrast imaging. Unlike conventional fluorophores suffering from aggregation-caused quenching, AIEgens exhibit enhanced luminescence when aggregated, enabling superior performance. This review delves into molecular mechanisms (AIE), demonstrating how strategic design unlocks exceptional and contrast, which crucial for distinguishing healthy diseased tissues. highlights key applications AIEgens, such as time-resolved imaging, second near-infrared window (NIR-II), advancement sensitivity to physical biochemical cue-responsive The development AIE technology promises transform healthcare early disease detection targeted therapies, potentially reshaping personalized medicine. paradigm shift biophotonics offers efficient tools decode complexities biological systems at level, bringing us closer a future where invisible becomes visible incurable treatable.

Language: Английский

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Integration of Motion and Stillness: A Paradigm Shift in Constructing Nearly Planar NIR-II AIEgen with Ultrahigh Molar Absorptivity and Photothermal Effect for Multimodal Phototheranostics

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The two contradictory entities in nature often follow the principle of unity opposites, leading to optimal overall performance. Particularly, aggregation-induced emission luminogens (AIEgens) with donor–acceptor (D–A) structures exhibit tunable optical properties and versatile functionalities, offering significant potential revolutionize cancer treatment. However, trapped by low molar absorptivity (ε) owing distorted configurations, ceilings their photon-harvesting capability corresponding phototheranostic performance still fall short. Therefore, a research paradigm from twisted configuration near-planar structure featuring high ε is urgently needed for AIEgens development. Herein, introducing strategy "motion stillness" into highly planar A–D–A skeleton, we successfully developed near-infrared (NIR)-II AIEgen Y5-2BO-2BTF, which boasts an impressive 1.06 × 105 M–1 cm–1 photothermal conversion efficiency (PCE) 77.8%. modification steric hindrance on benzene ring acceptor unit aggregation-caused quenching counterpart Y5-2BO, meta-CF3-substituted naphthyl, leads reversely staggered packing various intermolecular noncovalent conformational locks Y5-2BO-2BTF ("stillness"). Furthermore, −CF3 moiety acted as flexible motion ultralow energy barrier, significantly facilitating process loose aggregates ("motion"). Accordingly, nanoparticles enabled tumor eradication pulmonary metastasis inhibition through NIR-II fluorescence-photoacoustic-photothermal imaging-navigated type I photodynamic-photothermal therapy. This work provides first evidence that conformation stacking arrangement could serve novel molecular design direction AIEgens, shedding new light constructing superior agents bioimaging

Language: Английский

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A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

The shortwave infrared (SWIR) region is an ideal spectral window for next-generation bioimaging to harness improved penetration and reduced phototoxicity. SWIR activity may also be accessed via supramolecular dye aggregation. Unfortunately, development of aggregation remains challenging. We propose a crystal-aided aggregate synthesis (CAASH) approach introduce layer rationality the J-aggregate successful water-soluble JV-aggregate with bisbenzannulated silicon rhodamine scaffold (ESi5). resulting SWIR-aggregates exhibit excellent stabilities toward organic solvents, pH, sonication, photobleaching, thiols, endogenous oxidative species. Notably, aggregates have high structure-dependent melting temperature ca. 330-335 K. In fact, heating/annealing process can exploited reduce disorder. are biocompatible broad potential in vivo fluorescence photoacoustic imaging more. While has applications, stable absorbers/emitters challenging access. Here, authors report J-aggregates bioimaging.

Language: Английский

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Plasmon-enhanced NIR-II photoluminescence of rare-earth oxide nanoprobes for high-sensitivity optical temperature sensing

Optics Letters, Journal Year: 2024, Volume and Issue: 49(22), P. 6489 - 6489

Published: Oct. 23, 2024

With ongoing advancements in photothermal therapy, achieving efficient tumor cell eradication while minimizing damage to healthy tissues necessitates a highly effective and non-invasive real-time temperature monitoring technique for human tissues. Herein, we report near-infrared (NIR)-II optical sensing nanoprobe featuring rare-earth-doped gadolinium oxide nanocrystals (RENCs) attached the dumbbell mesoporous silica-coated gold nanorods (AuNRs). The composite presents an intense absorption NIR region, NIR-II photoluminescence (PL) increases by 97.2 102-fold compared pure RENCs upon 980 nm irradiation. localized electric field generated through surface plasmon resonance effects of AuNRs demonstrated dumbbell-shaped distribution that aligns with structure nanoprobes, maximizing PL enhancement RENCs. Moreover, emissions are changed rising temperature, exceptional relative sensitivity 7.25% K

Language: Английский

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