Architecture of Vanadium‐Based MXene Dysregulating Tumor Redox Homeostasis for Amplified Nanozyme Catalytic/Photothermal Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Sept. 21, 2023

Abstract Taking the significance of special microenvironment for tumor cell survival into account, disrupting redox homeostasis is highly prospective improving therapeutic efficacy. Herein, a multifunctional 2D vanadium‐based MXene nanoplatform, V 4 C 3 /atovaquone@bovine albumin (V /ATO@BSA, abbreviated as VAB) has been elaborately constructed ATO‐enhanced nanozyme catalytic/photothermal therapy. The within cells eventually disrupted, showing remarkable anti‐tumor effect. VAB nanoplatform with mixed vanadium valence states can induce cascade catalyzed reactions in microenvironment, generating plenty reactive oxygen species (ROS) effective glutathione consumption to amplify oxidative stress. Meanwhile, stable and strong photothermal effect under near‐infrared irradiation not only causes necrosis cells, but also improves its peroxidase‐like activity. In addition, release ATO effectively alleviate endogenous limit triphosadenine formation inhibit mitochondrial respiration. As result, expression heat shock proteins suppressed overcome thermoresistance production ROS be further promoted due injury. Moreover, presents high photoacoustic imaging performances. brief, provide therapy broadening biomedical applications MXene.

Language: Английский

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Tumor microenvironment‐responsive delivery nanosystems reverse immunosuppression for enhanced CO gas/immunotherapy

Exploration, Journal Year: 2023, Volume and Issue: 3(6)

Published: July 27, 2023

Carbon monoxide (CO) gas therapy demonstrates great potential to induce cancer cell apoptosis and antitumor immune responses, which exhibits tremendous in treatment. However, the therapeutic efficacy of CO is inhibited by immunosuppressive tumor microenvironment (TME). Herein, a facile strategy proposed construct hollow-structured rough nanoplatforms boost immunity simultaneously reverse immunosuppression exploring intrinsic immunomodulatory properties morphological optimization nanomaterials. The TME-responsive delivery nanosystems (M-RMH) are developed encapsulating prodrug within hollow MnO

Language: Английский

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Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(5), P. 2643 - 2692

Published: Jan. 1, 2024

This review discusses the structures and engineering strategies of nanocatalysts, highlighting their underlying mechanisms applications in cancer immunotherapy.

Language: Английский

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A Vacancy‐Engineering Ferroelectric Nanomedicine for Cuproptosis/Apoptosis Co‐Activated Immunotherapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(30)

Published: May 4, 2024

Abstract Low efficacy of immunotherapy due to the poor immunogenicity most tumors and their insufficient infiltration by immune cells highlights importance inducing immunogenic cell death activating system for achieving better treatment outcomes. Herein, ferroelectric Bi 2 CuO 4 nanoparticles with rich copper vacancies (named BCO‐V Cu ) are rationally designed engineered ferroelectricity‐enhanced apoptosis, cuproptosis, subsequently evoked immunotherapy. In this structure, suppressed recombination electron–hole pairs band bending polarization lead high catalytic activity, triggering reactive oxygen species bursts apoptosis. The fragments produced apoptosis serve as antigens activate T cells. Moreover, generated charge catalysis, nanomedicine can act “a smart switch” open membrane, promote nanomaterial endocytosis, shut down + outflow pathway evoke thus a strong response is triggered reduced content adenosine triphosphate. Ribonucleic acid transcription tests reveal pathways related activation. Thus, study firstly demonstrates feasible strategy enhancing using single semiconductor‐induced cuproptosis.

Language: Английский

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Glutathione Induced In situ Synthesis of Cu Single‐Atom Nanozymes with Anaerobic Glycolysis Metabolism Interference for Boosting Cuproptosis

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(18)

Published: Feb. 23, 2024

Abstract Single‐atom nanozyme (SAzyme) has sparked increasing interest for catalytic antitumor treatment due to their more tunable and diverse active sites than natural metalloenzymes in complex physiological conditions. However, it is usually a hard task precisely conduct catalysis at tumor after intravenous injection of those SAzyme with high reactivity. Moreover, the explorations SAzymes anticancer application are still its infancy need be developed. Herein, an situ synthesis strategy Cu was constructed convert adsorbed copper ions into isolated atoms anchored by oxygen (Cu−O 2 /Cu−O 4 ) via GSH‐responsive deformability supports. Our results suggest that activation process could further facilitate dissociation consumption glutathione, thereby leading deposition cytoplasm triggering cuproptosis. peroxidase‐like activity enabled intracellular reactive species production, resulting specifically disturbance metabolism pathway. Meanwhile, exposed glucose transporter (GLUT) inhibitor phloretin (Ph) can block glycose uptake boost cuproptosis efficacy. Overall, this effectively diminished off‐target effects SACs‐induced therapies introduced promising paradigm advancing cuproptosis‐associated therapies.

Language: Английский

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Intermetallics triggering pyroptosis and disulfidptosis in cancer cells promote anti-tumor immunity

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 8, 2024

Pyroptosis, an immunogenic programmed cell death, could efficiently activate tumor immunogenicity and reprogram immunosuppressive microenvironment for boosting cancer immunotherapy. However, the overexpression of SLC7A11 promotes glutathione biosynthesis maintaining redox balance countering pyroptosis. Herein, we develop intermetallics modified with glucose oxidase (GOx) soybean phospholipid (SP) as pyroptosis promoters (Pd

Language: Английский

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Lysosomal Rupture‐Mediated “Broken Window Effect” to Amplify Cuproptosis and Pyroptosis for High‐Efficiency Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)

Published: Feb. 23, 2024

Abstract Autophagy, a lysosome‐involved degradation pathway, as self‐protective cellular process, always weakens the efficiency of tumor therapies. Herein, for first time, biodegradable copper (Cu) ions doped layered double hydroxide (Cu‐LDH) nanoparticles are reported cancer immunotherapy via lysosomal rupture‐mediated “Broken Window Effect”. Only injection Cu‐LDH single therapeutic agent achieves various organelles destruction after rupture, well abnormal aggregation Cu in cells cuproptosis and pyroptosis. More importantly, autophagy inhibition caused by rupture improves overload‐mediated pyroptosis blocking lysosome‐mediated bulk leading to good anti‐tumor immune responses ultimately high‐efficiency growth inhibition. This Effect” provides new paradigm enhanced therapy.

Language: Английский

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NIR-II Light-Driven Genetically Engineered Exosome Nanocatalysts for Efficient Phototherapy against Glioblastoma

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(22), P. 15251 - 15263

Published: May 23, 2024

Glioblastoma (GBM) poses a significant therapeutic challenge due to its invasive nature and limited drug penetration through the blood–brain barrier (BBB). In response, here we present an innovative biomimetic approach involving development of genetically engineered exosome nanocatalysts (Mn@Bi2Se3@RGE-Exos) for efficient GBM therapy via improving BBB enzyme-like catalytic activities. Interestingly, photothermally activatable multiple reactivity is observed in such nanosystem. Upon NIR-II light irradiation, Mn@Bi2Se3@RGE-Exos are capable converting hydrogen peroxide into hydroxyl radicals, oxygen, superoxide providing peroxidase (POD), oxidase (OXD), catalase (CAT)-like nanocatalytic cascade. This consequently leads strong oxidative stresses damage cells. vitro, vivo, proteomic analysis further reveal potential disruption cellular homeostasis, enhancement immunological induction cancer cell ferroptosis, showcasing great promise anticancer efficacy against with favorable biosafety profile. Overall, success this study provides feasible strategy future design clinical stimuli-responsive medicine, especially context challenging brain cancers like GBM.

Language: Английский

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Endogenous Nitric Oxide Releases In Situ for RNS/ROS Synergistic Cancer Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(17)

Published: Jan. 2, 2024

Abstract Gas therapy, represented by nitric oxide (NO), has shown a powerful anti‐tumor effect. However, current NO therapy relies on precursors, which are often released prematurely during in vivo delivery, resulting poor targeting and obvious toxic side effects. Herein, core/shell‐structured nanocatalyst is designed prepared to catalyze the generation of tumor without introduction donor. In this system, C‐Z@CM coating octahedron Cu‐MOF with nano‐ZnO, camouflaging homologous cell membrane. After nanomedicine taken up cells, ZnO reacts situ endogenous S‐nitrosoglutathione (GSNO), highly expressed tumors, continuously stably generate NO. addition, dispersed copper ions acts as catalytic active centers Fenton‐like reaction, catalyzes H 2 O large number hydroxyl radicals ( • OH). Importantly, cascade reactive oxygen species (ROS) leads massive production more lethal nitrogen (RNS), further enhancing therapeutic Catalytic high concentrations tumor, combined ROS RNS, accompanied glutathione (GSH) depletion, achieving effective suppression.

Language: Английский

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Smart responsive Fe/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 6, 2024

Abstract Background The prognosis for hepatocellular carcinoma (HCC) remains suboptimal, characterized by high recurrence and metastasis rates. Although metalloimmunotherapy has shown potential in combating tumor proliferation, metastasis, current apoptosis-based fails to elicit sufficient immune response HCC. Results A smart responsive bimetallic nanovaccine was constructed induce immunogenic cell death (ICD) through pyroptosis enhance the efficacy of cGAS-STING pathway. composed manganese-doped mesoporous silica as a carrier, loaded with sorafenib (SOR) modified MIL-100 (Fe), where Fe 3+ , SOR, Mn 2+ were synchronized released into help microenvironment (TME). Afterward, worked synergistically SOR-induced (via both classical nonclassical signaling pathways), causing outflow abundant factors, which contributes dendritic (DC) maturation, exposure double-stranded DNA (dsDNA). Subsequently, exposed dsDNA jointly activated pathway induced release type I interferons, further led DC maturation. Moreover, -related T1 magnetic resonance imaging (MRI) used visually evaluate functionality nanovaccine. Conclusion utilization metallic nanovaccines pyroptosis-mediated activation provides promising paradigm HCC treatment.

Language: Английский

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