Scientific Reports,
Journal Year:
2020,
Volume and Issue:
10(1)
Published: Dec. 17, 2020
Abstract
In
humans,
sleep
regulation
is
tightly
linked
to
social
times
that
assign
local
time
events,
such
as
school,
work,
or
meals.
The
impact
of
these
times,
collectively—social
pressure,
on
has
been
studied
epidemiologically
via
quantification
the
discrepancy
between
workdays
and
those
work-free
days.
This
known
jetlag
(SJL).
COVID-19-mandated
restrictions
(SR)
constituted
a
global
intervention
by
affecting
worldwide.
We
launched
Global
Chrono
Corona
Survey
(GCCS)
queried
sleep–wake
before
during
SR
(
preSR
inSR
).
11,431
adults
from
40
countries
responded
April
4
May
6,
2020.
final
sample
consisted
7517
respondents
(68.2%
females),
who
had
32.7
±
9.1
(mean
sd)
days
under
SR.
led
robust
changes:
mid-sleep
free
was
delayed
50
22
min,
respectively;
duration
increased
26
min
but
shortened
9
days;
SJL
decreased
~
30
min.
On
,
in
most
people
approached
their
Changes
correlated
with
-use
alarm
clocks
were
larger
young
adults.
data
indicate
massive
deficit
pre-pandemic
provide
insights
actual
need
different
age-groups
suggest
tolerable
about
20
Relaxed
pressure
promotes
more
sleep,
smaller
reduced
use
clocks.
Biology,
Journal Year:
2019,
Volume and Issue:
8(3), P. 54 - 54
Published: July 12, 2019
The
Munich
ChronoType
Questionnaire
(MCTQ)
has
now
been
available
for
more
than
15
years
and
its
original
publication
cited
1240
times
(Google
Scholar,
May
2019).
Additionally,
online
version,
which
was
until
July
2017,
produced
almost
300,000
entries
from
all
over
the
world
(MCTQ
database).
MCTQ
gone
through
several
versions,
translated
into
13
languages,
validated
against
other
objective
measures
of
daily
timing
in
independent
studies.
Besides
being
used
as
a
method
to
correlate
circadian
features
human
biology
with
factors—ranging
health
issues
geographical
factors—the
gave
rise
quantification
old
wisdoms,
like
“teenagers
are
late”,
new
concepts,
social
jetlag.
Some
MCTQ’s
simplicity
some
view
it
critically.
Therefore,
is
time
present
self-critical
on
MCTQ,
address
misunderstandings,
give
definitions
MCTQ-derived
chronotype
concept
The Journal of Clinical Endocrinology & Metabolism,
Journal Year:
2015,
Volume and Issue:
100(12), P. 4612 - 4620
Published: Nov. 18, 2015
Shift
work,
which
imposes
a
habitual
disruption
in
the
circadian
system,
has
been
linked
to
increased
incidence
of
cardiometabolic
diseases,
and
acute
misalignment
alters
various
metabolic
processes.
However,
it
remains
unclear
whether
day-to-day
dysregulation
contributes
these
risks
beyond
poor
sleep
other
behavioral
characteristics.
Journal of Clinical Investigation,
Journal Year:
2018,
Volume and Issue:
128(6), P. 2157 - 2167
Published: May 31, 2018
All
species
organize
behaviors
to
optimally
match
daily
changes
in
the
environment,
leading
pronounced
activity/rest
cycles
that
track
light/dark
cycle.
Endogenous,
approximately
24-hour
circadian
rhythms
brain,
autonomic
nervous
system,
heart,
and
vasculature
prepare
cardiovascular
system
for
optimal
function
during
these
anticipated
behavioral
cycles.
Cardiovascular
rhythms,
however,
may
be
a
double-edged
sword.
The
normal
amplified
responses
morning
aid
transition
from
sleep
activity,
but
such
exaggerated
are
potentially
perilous
individuals
susceptible
adverse
events.
Indeed,
occurrence
of
stroke,
myocardial
infarction,
sudden
cardiac
death
all
have
patterns,
striking
most
frequently
morning.
Furthermore,
chronic
disruptions
clock,
as
with
night-shift
work,
contribute
increased
risk.
Here
we
highlight
importance
disease,
identify
opportunities
optimizing
timing
medications
disease.
Nutrients,
Journal Year:
2018,
Volume and Issue:
10(6), P. 761 - 761
Published: June 13, 2018
High
fat
diet-induced
changes
in
gut
microbiota
have
been
linked
to
intestinal
permeability
and
metabolic
endotoxemia,
which
is
related
disorders.
However,
the
influence
of
a
high-glucose
(HGD)
or
high-fructose
(HFrD)
diet
on
largely
unknown.
We
performed
HGD-
HFrD-fed
C57BL/6J
mice
by
16S
rRNA
analysis.
Gut
microbiota-derived
endotoxin-induced
disorders
were
evaluated
glucose
insulin
tolerance
test,
permeability,
Western
blot
histological
found
that
HGD
HFrD
groups
had
comparatively
higher
blood
endotoxin
levels,
mass,
dyslipidemia,
intolerance
without
bodyweight.
The
lost
microbial
diversity,
characterized
lower
proportion
Bacteroidetes
markedly
increased
Proteobacteria.
Moreover,
due
alterations
tight
junction
proteins
caused
inflammation.
Hepatic
inflammation
lipid
accumulation
also
groups.
levels
fructose
regulate
increase
precedes
development
inflammation,
accumulation,
ultimately
leading
hepatic
steatosis
normal-weight
obesity.
