Hydrogel bioelectronics

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(6), P. 1642 - 1667

Published: Nov. 26, 2018

Hydrogels have emerged as a promising bioelectronic interfacing material. This review discusses the fundamentals and recent advances in hydrogel bioelectronics.

Language: Английский

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Targeted neurotechnology restores walking in humans with spinal cord injury

Nature, Journal Year: 2018, Volume and Issue: 563(7729), P. 65 - 71

Published: Oct. 25, 2018

Language: Английский

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Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration

The Lancet, Journal Year: 2017, Volume and Issue: 389(10081), P. 1821 - 1830

Published: March 28, 2017

Language: Английский

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Brain-Machine Interfaces: From Basic Science to Neuroprostheses and Neurorehabilitation

Physiological Reviews, Journal Year: 2017, Volume and Issue: 97(2), P. 767 - 837

Published: March 9, 2017

Brain-machine interfaces (BMIs) combine methods, approaches, and concepts derived from neurophysiology, computer science, engineering in an effort to establish real-time bidirectional links between living brains artificial actuators. Although theoretical propositions some proof of concept experiments on directly linking the with machines date back early 1960s, BMI research only took off earnest at end 1990s, when this approach became intimately linked new neurophysiological methods for sampling large-scale brain activity. The classic goals BMIs are 1) unveil utilize principles operation plastic properties distributed dynamic circuits 2) create therapies restore mobility sensations severely disabled patients. Over past decade, a wide range applications have emerged, which considerably expanded these original goals. studies shown neural control over movements robotic virtual actuators that enact both upper lower limb functions. Furthermore, also incorporated ways deliver sensory feedback, generated external actuators, brain. has been forefront many discoveries, including demonstration that, through continuous use, tools can be assimilated by primate brain's body schema. Work led introduction novel neurorehabilitation strategies. As result efforts, long-term use recently implicated induction partial neurological recovery spinal cord injury

Language: Английский

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Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia

Nature Medicine, Journal Year: 2018, Volume and Issue: 24(11), P. 1677 - 1682

Published: Sept. 3, 2018

Language: Английский

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Spinal cord repair: advances in biology and technology

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(6), P. 898 - 908

Published: June 1, 2019

Language: Английский

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Topological supramolecular network enabled high-conductivity, stretchable organic bioelectronics

Science, Journal Year: 2022, Volume and Issue: 375(6587), P. 1411 - 1417

Published: March 24, 2022

Intrinsically stretchable bioelectronic devices based on soft and conducting organic materials have been regarded as the ideal interface for seamless biocompatible integration with human body. A remaining challenge is to combine high mechanical robustness good electrical conduction, especially when patterned at small feature sizes. We develop a molecular engineering strategy topological supramolecular network, which allows decoupling of competing effects from multiple building blocks meet complex requirements. obtained simultaneously conductivity crack-onset strain in physiological environment, direct photopatternability down cellular scale. further collected stable electromyography signals malleable octopus performed localized neuromodulation single-nucleus precision controlling organ-specific activities through delicate brainstem.

Language: Английский

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A Materials Roadmap to Functional Neural Interface Design

Advanced Functional Materials, Journal Year: 2017, Volume and Issue: 28(12)

Published: July 19, 2017

Abstract Advancements in neurotechnologies for electrophysiology, neurochemical sensing, neuromodulation, and optogenetics are revolutionizing scientific understanding of the brain while enabling treatments preventative measures a variety neurological disorders. The grand challenge neural interface engineering is to seamlessly integrate between neurobiology engineered technology record from modulate neurons over chronic timescales. However, biological inflammatory response implants, degeneration, long‐term material stability diminishes quality overtime. Recent advances functional materials aimed at solutions interfaces, yet, development deployment interfaces designed novel have introduced new challenges that been largely unaddressed. Many efforts solely focus on optimizing individual probe design parameters, such as softness or flexibility, downplay critical multidimensional interactions different physical properties device contribute overall performance biocompatibility. Moreover, use these present substantial difficulties must be addressed before regulatory approval human patients achievable. In this review, interdependence electrode components highlighted demonstrate current material‐based facing field engineering.

Language: Английский

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An exoskeleton controlled by an epidural wireless brain–machine interface in a tetraplegic patient: a proof-of-concept demonstration

The Lancet Neurology, Journal Year: 2019, Volume and Issue: 18(12), P. 1112 - 1122

Published: Oct. 3, 2019

Language: Английский

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Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Nature Neuroscience, Journal Year: 2018, Volume and Issue: 21(12), P. 1728 - 1741

Published: Oct. 31, 2018

Language: Английский

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