Inflammation and aging: signaling pathways and intervention therapies DOI Creative Commons
Xia Li, Chentao Li, Wanying Zhang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: June 8, 2023

Abstract Aging is characterized by systemic chronic inflammation, which accompanied cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the multidimensional complexity of aging, there an urgent need for a systematic organization inflammaging through dimensionality reduction. Factors secreted senescent cells, known as senescence-associated secretory phenotype (SASP), promote inflammation can induce senescence in normal cells. At same time, accelerates immune resulting weakened function inability to clear cells inflammatory factors, creates vicious cycle senescence. Persistently elevated levels organs such bone marrow, liver, lungs cannot be eliminated leading damage aging-related Therefore, has been recognized endogenous factor elimination could potential strategy anti-aging. Here we discuss at molecular, cellular, organ, disease levels, review current aging models, implications cutting-edge single cell technologies, well anti-aging strategies. Since preventing alleviating diseases improving overall quality life are ultimate goals research, our highlights critical features mechanisms along with latest developments future directions providing theoretical foundation novel practical

Language: Английский

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association DOI Creative Commons

Connie W. Tsao,

Aaron W. Aday, Zaid Almarzooq

et al.

Circulation, Journal Year: 2022, Volume and Issue: 145(8)

Published: Jan. 26, 2022

The American Heart Association, in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, weight) factors (cholesterol, blood pressure, glucose control) that contribute health. Statistical Update presents latest data on a range major clinical circulatory disease conditions (including congenital rhythm disorders, subclinical atherosclerosis, coronary failure, valvular venous peripheral artery disease) associated outcomes quality care, procedures, economic costs).

Language: Английский

Citations

4330
Gut microbiota in human metabolic health and disease DOI
Yong Fan, Oluf Pedersen

Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 19(1), P. 55 - 71

Published: Sept. 4, 2020

Language: Английский

Citations

3264
The Global Epidemic of the Metabolic Syndrome DOI
Mohammad G. Saklayen

Current Hypertension Reports, Journal Year: 2018, Volume and Issue: 20(2)

Published: Feb. 1, 2018

Language: Английский

Citations

3187
Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study DOI
Clara Depommier, Amandine Everard, Céline Druart

et al.

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(7), P. 1096 - 1103

Published: July 1, 2019

Language: Английский

Citations

1730
Extensive impact of non-antibiotic drugs on human gut bacteria DOI
Lisa Maier, Mihaela Pruteanu, Michael Kuhn

et al.

Nature, Journal Year: 2018, Volume and Issue: 555(7698), P. 623 - 628

Published: March 19, 2018

Language: Английский

Citations

1632
Temporal development of the gut microbiome in early childhood from the TEDDY study DOI Creative Commons
Christopher J. Stewart, Nadim J. Ajami, Jacqueline O’Brien

et al.

Nature, Journal Year: 2018, Volume and Issue: 562(7728), P. 583 - 588

Published: Oct. 1, 2018

The development of the microbiome from infancy to childhood is dependent on a range factors, with microbial–immune crosstalk during this time thought be involved in pathobiology later life diseases1–9 such as persistent islet autoimmunity and type 1 diabetes10–12. However, our knowledge, no studies have performed extensive characterization early large, multi-centre population. Here we analyse longitudinal stool samples 903 children between 3 46 months age by 16S rRNA gene sequencing (n = 12,005) metagenomic 10,867), part Environmental Determinants Diabetes Young (TEDDY) study. We show that developing gut undergoes three distinct phases progression: developmental phase (months 3–14), transitional 15–30), stable 31–46). Receipt breast milk, either exclusive or partial, was most significant factor associated structure. Breastfeeding higher levels Bifidobacterium species (B. breve B. bifidum), cessation milk resulted faster maturation microbiome, marked phylum Firmicutes. Birth mode also significantly phase, driven Bacteroides (particularly fragilis) infants delivered vaginally. increased diversity maturation, regardless birth mode. factors including geographical location household exposures (such siblings furry pets) represented important covariates. A nested case–control analysis revealed subtle associations microbial taxonomy diabetes. These data determine structural functional assembly provide foundation for targeted mechanistic investigation into consequences long-term health. Metagenomic TEDDY study shows breastfeeding structure, microbiome.

Language: Английский

Citations

1576
Role of gut microbiota in type 2 diabetes pathophysiology DOI Creative Commons
Manoj Gurung, Zhipeng Li,

Hannah You

et al.

EBioMedicine, Journal Year: 2020, Volume and Issue: 51, P. 102590 - 102590

Published: Jan. 1, 2020

A substantial body of literature has provided evidence for the role gut microbiota in metabolic diseases including type 2 diabetes. However, reports vary regarding association particular taxonomic groups with disease. In this systematic review, we focused on potential different bacterial taxa affecting We have summarized from 42 human studies reporting microbial associations disease, and identified supporting preclinical or clinical trials using treatments probiotics. Among commonly reported findings, genera Bifidobacterium, Bacteroides, Faecalibacterium, Akkermansia Roseburia were negatively associated T2D, while Ruminococcus, Fusobacterium, Blautia positively T2D. also discussed molecular mechanisms effects onset progression

Language: Английский

Citations

1370
The gut microbiome in atherosclerotic cardiovascular disease DOI Creative Commons
Zhuye Jie,

Huihua Xia,

Shilong Zhong

et al.

Nature Communications, Journal Year: 2017, Volume and Issue: 8(1)

Published: Oct. 4, 2017

The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of microbiome in relation diseases have not systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic disease (ACVD) 187 healthy controls. ACVD deviates status by increased abundance Enterobacteriaceae Streptococcus spp. and, functionally, potential for metabolism or transport several molecules important health. Although drug treatment represents confounding factor, status, current use, is major distinguishing feature this cohort. We identify common themes comparison data associated other cardiometabolic (obesity type 2 diabetes), liver cirrhosis, rheumatoid arthritis. Our represent comprehensive resource further investigations role promoting preventing as well related diseases.The may play authors controls, identifying microbial strains functions disease.

Language: Английский

Citations

1327
Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1 DOI Creative Commons
Daniel J. Drucker

Cell Metabolism, Journal Year: 2018, Volume and Issue: 27(4), P. 740 - 756

Published: April 1, 2018

Language: Английский

Citations

1276
A unified catalog of 204,938 reference genomes from the human gut microbiome DOI Creative Commons
Alexandre Almeida, Stephen Nayfach, Miguel Boland

et al.

Nature Biotechnology, Journal Year: 2020, Volume and Issue: 39(1), P. 105 - 114

Published: July 20, 2020

Comprehensive, high-quality reference genomes are required for functional characterization and taxonomic assignment of the human gut microbiota. We present Unified Human Gastrointestinal Genome (UHGG) collection, comprising 204,938 nonredundant from 4,644 prokaryotes. These encode >170 million protein sequences, which we collated in Protein (UHGP) catalog. The UHGP more than doubles number proteins comparison to those Integrated Gene Catalog. More 70% UHGG species lack cultured representatives, 40% annotations. Intraspecies genomic variation analyses revealed a large reservoir accessory genes single-nucleotide variants, many specific individual populations. collections will enable studies linking genotypes phenotypes microbiome. 200,000 prokaryotic they collated, providing comprehensive resources microbiome researchers.

Language: Английский

Citations

993