The effect of mind- and body-based interventions on poststroke depression and its neural mechanisms: A systematic review and meta-analysis DOI Creative Commons
Rangchun Hou,

Peter Bohao Yang,

Dalinda Isabel Sánchez-Vidaña

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Post-stroke depression (PSD) is recognized as the most common psychiatric disorder following a stroke, impacting subsequent recovery and quality of life stroke survivors. In recent years, physical activities mindfulness have been proven to improve depression, however, it remained unknown whether those interventions were also effective in treatment PSD. This systematic review aims assess effects mind- body-based on PSD their underlying neural mechanisms. The (PROSPERO registration number: CRD42024514565) searched CINAHL, Cochrane, PsycINFO, PubMed, Scopus up March 11, 2024, focusing English-language studies. Inclusion criteria encompassed randomized controlled trials patients with using validated assessment tools, targeting body-based, mind-based, or mind-body interventions, while excluding psychological counseling passive movements. Two authors conducted data extraction checks for accuracy, risk bias was assessed PEDro scale, which evaluates study design methodology, yielding maximum score 10 points. Data by independent reviewers. A total 68 studies included, involving 6,825 participants, 54 these included meta-analysis. average 6.51 indicates good methodological quality, combined scoring highest at 7.44, highlighting variability among Meta-analysis results demonstrate that all significant impact (p < 0.05), effect sizes follows: (n = 66, Hedges’ g -0.572), mind-based 4, -0.549), 52, -0.532), 10, -0.805). meta-analysis revealed significantly improved post-stroke are more than alone. It suggested integrate additional elements into daily exercises survivors clinical practice can further alleviate depressive symptoms.

Language: Английский

The relationship between depression and relative fat mass (RFM): A population-based study DOI Creative Commons
Xianlin Zhu,

Ya Yue,

Lin Li

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 356, P. 323 - 328

Published: April 11, 2024

Relative fat mass (RFM) is a novel indicator for measuring body fat. The relationship between RFM and depression was explored using National Health Nutrition Examination Survey (NHANES) data from 2005 to 2018.

Language: Английский

Citations

24
Pathogenesis, Diagnostics, and Therapeutics for Alzheimer's Disease: Breaking the Memory Barrier DOI Creative Commons

Pushpa Tryphena Kamatham,

Rashi K. Shukla, Dharmendra Kumar Khatri

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102481 - 102481

Published: Sept. 3, 2024

Alzheimer's disease (AD) is the most common cause of dementia and accounts for 60-70 % all cases. It affects millions people worldwide. AD poses a substantial economic burden on societies healthcare systems. progressive neurodegenerative disorder characterized by cognitive decline, memory loss, impaired daily functioning. As prevalence continues to increase, understanding its pathogenesis, improving diagnostic methods, developing effective therapeutics have become paramount. This comprehensive review delves into intricate mechanisms underlying AD, explores current state techniques, examines emerging therapeutic strategies. By revealing complexities this aims contribute growing body knowledge surrounding devastating disease.

Language: Английский

Citations

22
The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms DOI Creative Commons
Jiao Wang, Jiayi Lin,

Yanfang Deng

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 19, 2025

Major depressive disorder is a prevalent mental disorder, yet its pathogenesis remains poorly understood. Accumulating evidence implicates dysregulated immune mechanisms as key contributors to disorders. This review elucidates the complex interplay between peripheral and central components underlying pathology. Peripherally, systemic inflammation, gut dysregulation, dysfunction in organs including gut, liver, spleen adipose tissue influence brain function through neural molecular pathways. Within nervous system, aberrant microglial astrocytes activation, cytokine imbalances, compromised blood-brain barrier integrity propagate neuroinflammation, disrupting neurotransmission, impairing neuroplasticity, promoting neuronal injury. The crosstalk immunity creates vicious cycle exacerbating neuropathology. Unraveling these multifaceted immune-mediated provides insights into major disorder's pathogenic basis potential biomarkers targets. Modulating both responses represent promising multidimensional therapeutic strategy.

Language: Английский

Citations

5
Does multimodal exercise reduce C-reactive protein levels in major depressive disorder? Preliminary results from a randomized controlled trial DOI
Vagner Deuel de Oliveira Tavares, Felipe Barreto Schuch, Geovan Menezes de Sousa

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 183, P. 252 - 259

Published: Feb. 19, 2025

Language: Английский

Citations

2
Exercise as an antidepressant: exploring its therapeutic potential DOI Creative Commons

Dong-Joo Hwang,

Jung‐Hoon Koo,

Tae-Kyung Kim

et al.

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 12, 2023

The COVID-19 pandemic has increased the prevalence of depressive disorders worldwide, requiring alternative treatments beyond medication and psychotherapy. Exercise positive effects on brain; therefore, it emerged as a promising therapeutic option for individuals with depression. Considerable research involving humans animals offers compelling evidence to support mental health benefits physical activity or exercise mediated by regulation complex theoretical paradigms. However, challenges such conducting long-term follow-up assessments considering individual characteristics remain in human studies despite extensive efforts. While animal provide valuable insights into potential its impact outcomes related depression anxiety rodents exposed different stress paradigms, translating findings requires careful evaluation. More is needed establish precise prescription guidelines better understand relationship between disorders. Therefore, this concise review explores supporting intervention an antidepressant treatment underlying mechanisms.

Language: Английский

Citations

37
Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases DOI Creative Commons
José A. Santiago, Judith A. Potashkin

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: May 26, 2023

Neurodegenerative diseases have reached alarming numbers in the past decade. Unfortunately, clinical trials testing potential therapeutics proven futile. In absence of disease-modifying therapies, physical activity has emerged as single most accessible lifestyle modification with to fight off cognitive decline and neurodegeneration. this review, we discuss findings from epidemiological, clinical, molecular studies investigating modifications promoting brain health. We propose an evidence-based multidomain approach that includes activity, diet, training, sleep hygiene treat prevent neurodegenerative diseases.

Language: Английский

Citations

32
Exercise for Mental Well-Being: Exploring Neurobiological Advances and Intervention Effects in Depression DOI Creative Commons
Jianchang Ren, Haili Xiao

Life, Journal Year: 2023, Volume and Issue: 13(7), P. 1505 - 1505

Published: July 4, 2023

Depression is a common mental disorder in which patients often experience feelings of sadness, fatigue, loss interest, and pleasure. Exercise widely used intervention for managing depression, but the specific molecular mechanisms underlying its antidepressant effect are unclear. In this narrative review, we aim to synthesize current knowledge on molecular, neural, physiological through exercise exerts discuss various interventions depression. We conducted review literature topic Our suggests that impacts peripheral tryptophan metabolism, central inflammation, brain-derived neurotrophic factors peroxisome proliferator-activated receptor γ activating factor 1α (PGC-1α) skeletal muscles. The uncarboxylated osteocalcin facilitates "bone-brain crosstalk", corrects atypical expression brain-gut peptides, modulates cytokine production neurotransmitter release, regulates inflammatory pathways microRNA expression. Aerobic recommended at frequencies 3 5 times per week with medium high intensity. Here highlight significant potential therapy supported by effect. Understanding neural involved exercise's opens new avenues developing novel therapies

Language: Английский

Citations

30
Pro-inflammatory cytokines in stress-induced depression: Novel insights into mechanisms and promising therapeutic strategies DOI
Jun Chang,

Tingcan Jiang,

Xiaoqian Shan

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 131, P. 110931 - 110931

Published: Jan. 2, 2024

Language: Английский

Citations

16
From movement to motivation: a proposed framework to understand the antidepressant effect of exercise DOI Creative Commons
Emily Hird,

Ashley Slanina-Davies,

Glyn Lewis

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 4, 2024

Depression is the leading cause of disability worldwide, exerting a profound negative impact on quality life in those who experience it. associated with disruptions to several closely related neural and cognitive processes, including dopamine transmission, fronto-striatal brain activity connectivity, reward processing motivation. Physical activity, especially aerobic exercise, reduces depressive symptoms, but mechanisms driving its antidepressant effects are poorly understood. Here we propose novel hypothesis for understanding centred motivation, across different levels explanation. There robust evidence that exercise decreases systemic inflammation. Inflammation known reduce which turn strongly implicated effort-based decision making reward. Drawing broad range research humans animals, by reducing inflammation boosting consequent reward, initially specifically improves 'interest-activity' symptoms depression-namely anhedonia, fatigue subjective impairment - increasing propensity exert effort. Extending this framework topic control, explain how depression may also be conceptualised through an decision-making framework, help impairment. Understanding underlying could inform development intervention strategies, particular personalised interventions boost social prescribing.

Language: Английский

Citations

14
Health is beyond genetics: on the integration of lifestyle and environment in real-time for hyper-personalized medicine DOI Creative Commons
Myles Joshua Toledo Tan,

Harishwar Reddy Kasireddy,

Alfredo Bayu Satriya

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 7, 2025

Hyper-personalized medicine represents the cutting edge of healthcare, which aims to tailor treatment and prevention strategies uniquely each individual. Unlike traditional approaches, often adopt a one-size-fits-all or even broadly personalized approach based on broad genetic categories, hyper-personalized considers an individual's comprehensive health data by integrating unique biological, genetic, lifestyle, environmental influences. This method goes beyond simple profiling recognizing that outcomes are influenced complex interactions among our environment, daily routines, physiological processes responses.Central is integration lifestyle factors. Lifestyle habits, such as diet (Dalwood et al., 2020; Genel Marx Hepsomali & Groeger, 2021; Dinu 2022; Yang Sadler 2024), exercise (Chow Qiu Ross D'Onofrio 2023; Isath Mahindru Ashcroft 2024; Ponzano sleep patterns (Hepsomali Baranwal Eshera Lim Sletten Uccella, Weinberger 2023), directly impact health. Hence, understanding these factors helps interventions align with day-to-day realities Environmental factors, air quality (Cheek Markandeya Shukla Tang Abdul-Rahman Bedi Bhattacharya, climate (Coates Ebi Helldén Reismann Rocque Zhang Münzel Palmeiro-Silva exposure pollutants (Qadri Faiq, 2019; Petroni Lin Sun Xu Yu Levin Shetty Deziel Villanueva Sharma also play significant roles in determining outcomes. By continuously monitoring analyzing elements, healthcare providers can create dynamic plans adapt real-time changes. would allow for proactive measures optimized care.To enable model care, advanced technologies like quantum computing, artificial general intelligence (AGI), internet things (IoT), 6G connectivity crucial roles. Quantum computing offers ability process vast intricate datasets, those required between markers, exposures, choices, far greater speed accuracy than classical (Munshi Kumar Stefano, Ullah Garcia-Zapirain, 2024). AGI, its adaptive learning capabilities, analyze make sense this provide precise, evolving recommendations change patient's environment does (Liu Mitchell, Tu IoT devices, including wearables sensors, gather continuous from individuals, tracking physical activity, biometrics, conditions humidity (Puri Islam Mathkor Rocha Šajnović Salam, With advent connectivity, seamlessly transferred processed real time, enabling instant feedback intervention (Nayak Patgiri, Nguyen Ahad Kumar, Kaur, Mahmood Mihovska 2024).Together, form backbone model, will push medical practices highly responsive, individual-centered As advancements continue evolve, has potential fundamentally reshape offering truly support long-term well-being.

Language: Английский

Citations

1