Engineering Antimicrobial Metal–Phenolic Network Nanoparticles with High Biocompatibility for Wound Healing

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(6)

Published: Nov. 24, 2023

Antibiotic-resistant bacteria pose a global health threat by causing persistent and recurrent microbial infections. To address this issue, antimicrobial nanoparticles (NPs) with low drug resistance but potent bactericidal effects have been developed. However, many of the developed NPs display poor biosafety their synthesis often involves complex procedures modes action are unclear. Herein, simple strategy is reported for designing metal-phenolic network (am-MPN) through one-step assembly seeding agent (diethyldithiocarbamate), natural polyphenols, metal ions (e.g., Cu

Language: Английский

---

Direct Assembly of Metal‐Phenolic Network Nanoparticles for Biomedical Applications

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(45)

Published: Oct. 6, 2023

Coordination assembly offers a versatile means to developing advanced materials for various applications. However, current strategies assembling metal-organic networks into nanoparticles (NPs) often face challenges such as the use of toxic organic solvents, cytotoxicity because synthetic ligands, and complex synthesis procedures. Herein, we directly assemble NPs using metal ions polyphenols (i.e., metal-phenolic (MPNs)) in aqueous solutions without templating or seeding agents. We demonstrate role buffers (e.g., phosphate buffer) governing NP formation engineering physicochemical properties tunable sizes from 50 270 nm) by altering conditions. A library MPN is prepared natural ions. Diverse functional cargos, including anticancer drugs proteins with different molecular weights isoelectric points, are readily loaded within applications biocatalysis, therapeutic delivery) direct mixing, surface modification, owing strong affinity guest molecules. This study provides insights mechanism complexes simple strategy engineer nanosized desired diverse biotechnological

Language: Английский

---

Flexible–robust MOFs/HOFs for challenging gas separations

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 505, P. 215660 - 215660

Published: Jan. 30, 2024

Language: Английский

---

Enhanced Charge Transfer Process and Photocatalytic Activity over a Phosphonate‐based MOF via Amorphization Strategy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(15)

Published: Feb. 16, 2024

Recently, amorphous materials have gained great attention as an emerging kind of functional material, and their characteristics such isotropy, absence grain boundaries, abundant defects are very likely to outrun the disadvantages crystalline counterparts, low conductivity, ultimately lead improved charge transfer efficiency. Herein, we investigated effect amorphization on process photocatalytic performance with a phosphonate-based metal-organic framework (FePPA) research object. Comprehensive experimental results suggest that compared FePPA, FePPA has more distorted metal nodes, which affects electron distribution consequently improves photogenerated separation Meanwhile, nodes in also greatly promote adsorption activation O

Language: Английский

---

Metal‐Phenolic Nanocloaks on Cancer Cells Potentiate STING Pathway Activation for Synergistic Cancer Immunotherapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(12)

Published: Feb. 2, 2024

Abstract Due to the presence of natural neoantigens, autologous tumor cells hold great promise as personalized therapeutic vaccines. Yet cell vaccines require multi‐step production that frequently leads loss immunoreactive antigens, causing insufficient immune activation and significantly hampering their clinical applications. Herein, we introduce a novel whole‐cell cancer vaccine by cloaking with lipopolysaccharide‐decorated manganese(II)‐phenolic networks (MnTA nanocloaks) evoke tumor‐specific response for highly efficacious synergistic immunotherapy. The polyphenols coordinate Mn 2+ immediately adhere surface individual cells, thereby forming nanocloak encapsulating neoantigens. Subsequent decoration lipopolysaccharide induces internalization dendritic where ions are released in cytosol, further facilitating stimulator interferon genes (STING) pathway. Highly effective suppression was observed combining nanocloaked treatment anti‐programmed death ligand 1 (anti‐PD‐L1) antibodies‐mediated checkpoint blockade therapy. Our work demonstrates universal yet simple strategy engineer cell‐based nanobiohybrid system enhanced

Language: Английский

---

Structural features of lanthanide coordination polymers with catalytic properties

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1304, P. 137687 - 137687

Published: Feb. 2, 2024

Language: Английский

---

Metal–phenolic network composites: from fundamentals to applications

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(22), P. 10800 - 10826

Published: Jan. 1, 2024

This review provides a guideline for the rational design of metal–phenolic network (MPN) composites—which are fabricated from MPN and one or more functional components ( e.g. , drugs, proteins)—for various applications across diverse disciplines.

Language: Английский

---

Multifunctional Copper‐Phenolic Nanopills Achieve Comprehensive Polyamines Depletion to Provoke Enhanced Pyroptosis and Cuproptosis for Cancer Immunotherapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(45)

Published: Sept. 17, 2024

Abstract The overexpression of polyamines in tumor cells contributes to the establishment immunosuppressive microenvironment and facilitates growth. Here, it have ingeniously designed multifunctional copper‐piceatannol/HA nanopills (Cu‐Pic/HA NPs) that effectively cause total intracellular depletion by inhibiting synthesis, depleting polyamines, impairing uptake, resulting enhanced pyroptosis cuproptosis, thus activating a powerful immune response achieve anti‐tumor therapy. Mitochondrial dysfunction from overall not only leads surge copper ions mitochondria, thereby causing aggregation toxic proteins induce but also triggers accumulation reactive oxygen species (ROS) within which further upregulates expression zDHHC5 zDHHC9 promote palmitoylation gasdermin D (GSDMD) GSDMD‐N, ultimately inducing pyroptosis. Then occurrence cuproptosis is conductive remodel microenvironment, responses growth metastasis. This therapeutic strategy through comprehensive provides novel template for cancer immunotherapy.

Language: Английский

---

Luminescent Lanthanide Infinite Coordination Polymers for Ratiometric Sensing Applications

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 396 - 396

Published: Jan. 18, 2025

Ratiometric lanthanide coordination polymers (Ln-CPs) are advanced materials that combine the unique optical properties of ions (e.g., Eu3+, Tb3+, Ce3+) with structural flexibility and tunability polymers. These widely used in biological chemical sensing, environmental monitoring, medical diagnostics due to their narrow-band emission, long fluorescence lifetimes, excellent resistance photobleaching. This review focuses on composition, sensing mechanisms, applications ratiometric Ln-CPs. The mechanism relies two distinct emission bands, which provides a self-calibrating, reliable, precise method for detection. relative intensity ratio between these bands varies concentration target analyte, enabling real-time monitoring minimizing interference. approach is particularly suitable detecting trace analytes use complex environments where factors like background noise, temperature fluctuations, light variations may affect results. Finally, we outline future research directions improving design synthesis Ln-CPs, such as incorporating long-lifetime reference luminescent molecules, exploring near-infrared systems, developing up-conversion or two-photon materials. Progress areas could significantly broaden scope Ln-CP applications, especially biosensing, other fields.

Language: Английский

---

Customizable Supraparticles Constructed from Catechol‐Terminated Molecular Building Blocks with Controllable Intermolecular Interactions**

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(29)

Published: May 20, 2023

Colloidal supraparticles integrated with multicomponent primary particles come emerging or synergetic functionalities. However, achieving the functional customization of remains a great challenge because limited options building blocks tailorability and extensibility. Herein, we developed universal approach to construct customizable desired properties from molecular obtained by covalent conjugation catechol groups series orthogonal groups. These catechol-terminated can assemble into driven various intermolecular interactions (i.e. metal-organic coordination, host-guest, hydrophobic interactions), then further governed catechol-mediated interfacial interactions. Our strategy enables formation diverse functionalities, such as dual-pH responsiveness, light-controllable permeability, non-invasive fluorescence labeling living cells. The ease which these be fabricated, ability tailor their chemical physical through choice metals used, should enable variety applications.

Language: Английский

---