Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122914 - 122914
Published: Oct. 23, 2024
Language: Английский
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(34)
Published: Sept. 22, 2023
Additive manufacturing (AM), which is based on the principle of layer-by-layer shaping and stacking discrete materials, has shown significant benefits in fabrication complicated implants for tissue engineering (TE). However, many native tissues exhibit anisotropic heterogenous constructs with diverse components functions. Consequently, replication biomimetic using conventional AM processes a single material challenging. Multimaterial 3D 4D bioprinting (with time as fourth dimension) emerged promising solution constructing multifunctional that can mimic host microenvironment better than single-material alternatives. Notably, 4D-printed multimaterial architectures provide time-dependent programmable dynamic promote cell activity regeneration response to external stimuli. This paper first presents typical design strategies TE applications. Subsequently, latest are discussed, along their advantages challenges. In particular, potential smart highlighted. Furthermore, this review provides insights into how facilitate realization next-generation
Language: Английский
Citations
57
Nature Reviews Materials, Journal Year: 2023, Volume and Issue: 9(2), P. 100 - 118
Published: Dec. 22, 2023
Language: Английский
Citations
52
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 347, P. 122739 - 122739
Published: Sept. 12, 2024
Language: Английский
Citations
12
Materials Today Bio, Journal Year: 2024, Volume and Issue: 25, P. 101004 - 101004
Published: Feb. 16, 2024
Extracellular matrix (ECM) stiffening is a common occurrence during the progression of many diseases, such as breast cancer. To accurately mimic pathophysiological context disease within 3D in vitro models, there high demand for smart biomaterials which replicate dynamic and temporal mechanical cues diseased states. This study describes preclinical model, using cancer an example, replicates plasticity tumour microenvironment by incorporating (3-week progression) biomechanical tissue-specific hydrogel microenvironment. The composite formulation, integrating adipose-derived decellularised ECM (AdECM) silk fibroin, was initially crosslinked visible light-mediated system, then progressively stiffened through spontaneous secondary structure interactions inherent between polymer chains (∼10–15 kPa increase, with final stiffness 25 kPa). When encapsulated cultured vitro, MCF-7 cells formed numerous, large spheroids (>1000 μm2 area), however, progressive stiffening, demonstrated growth arrest underwent phenotypic changes resulting intratumoral heterogeneity. Unlike widely-investigated static this allowed to be observed, fostered development mature organoid-like spheroids, mimicked both organisation acinar-structures epithelium. contained central population expressed aggressive cellular programs, evidenced increased fibronectin expression reduction E-cadherin. heterogeneity observed model more reflective physiological tumours, demonstrating importance establishing models future work. Overall, developed novel strategy uncouple properties from complexities offers potential wide applicability other addition dECM materials.
Language: Английский
Citations
10
Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(7), P. 461 - 479
Published: June 17, 2024
Language: Английский
Citations
8
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: June 25, 2024
Abstract Cell spheroids (esp. organoids) as 3D culture platforms are popular models for representing cell–cell and cell–extracellular matrix (ECM) interactions, bridging the gap between 2D cell cultures natural tissues. with spatially organized multiple types preferred gaining comprehensive insights into tissue pathophysiology constructing in vitro tissues disease because of complexities In recent years, an assembly strategy using (or living building blocks has been developed to construct complex spatial organization. Here, a overview advances multispheroid studies is provided. The different mechanisms techniques, i.e., automated directed assembly, noncontact remote programmed self‐assembly, introduced. processing steps, advantages, technical limitations existing methodologies summarized. Applications strategies modeling, drug screening, engineering, organogenesis reviewed. Finally, this review concludes by emphasizing persistent issues future perspectives, encouraging researchers adopt techniques generating advanced that better resemble real
Language: Английский
Citations
8
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(16), P. 8306 - 8378
Published: Jan. 1, 2024
As natural living substances, microorganisms have emerged as useful resources in medicine for creating microbe-material hybrids ranging from nano to macro dimensions. The engineering of microbe-involved nanomedicine capitalizes on the distinctive physiological attributes microbes, particularly their intrinsic "living" properties such hypoxia tendency and oxygen production capabilities. Exploiting these remarkable characteristics combination with other functional materials or molecules enables synergistic enhancements that hold tremendous promise improved drug delivery, site-specific therapy, enhanced monitoring treatment outcomes, presenting substantial opportunities amplifying efficacy disease treatments. This comprehensive review outlines microbial derivatives used biomedicine specific advantages therapeutic application. In addition, we delineate fundamental strategies mechanisms employed constructing hybrids. diverse biomedical applications constructed hybrids, encompassing bioimaging, anti-tumor, anti-bacteria, anti-inflammation diseases therapy are exhaustively illustrated. We also discuss current challenges prospects associated clinical translation hybrid platforms. Therefore, unique versatility potential exhibited by position them promising candidates development next-generation biomaterials theranostic functionalities.
Language: Английский
Citations
7
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 178, P. 24 - 40
Published: March 7, 2024
Bone metastasis primarily occurs when breast, prostate, or lung cancers disseminate tumoral cells into bone tissue, leading to a range of complications in skeletal tissues and, severe cases, paralysis resulting from spinal cord compression. Unfortunately, our understanding pathophysiological mechanisms is incomplete and the translation research clinic has been slow, mainly due lack credible ex vivo models study disease progression. Development reliable rational how tumor become circulating then invade sequentially colonize are great need. Advances tissue engineering technologies offers 3D alternatives which answer relevant questions towards cancer evolution key functional properties progression as well prognosis therapeutic approach. Here we performed an overview cellular involved including short summary normal physiology initiation Also, comprehensively summarized current advances methodologies fabrication based on state-of-the-art printing recapitulate structural biological features native tissue. STATEMENT OF SIGNIFICANCE: This review provides comprehensive collective findings relation various printed utilized for investigating specific diseases, related characteristic functions chemotherapeutic drug screening. These evaluated compared, terms their ability physiological microenvironment. Various biomaterials (natural synthetic polymers ceramic substrates) strategies design architecture used discussed here. clearly out-lines challenges prospects by focusing required perspective clinical application these
Language: Английский
Citations
5
Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(6), P. 518 - 532
Published: Jan. 10, 2024
Language: Английский
Citations
4
ACS Nano, Journal Year: 2024, Volume and Issue: 18(12), P. 9176 - 9186
Published: March 18, 2024
Immunotherapy plays a vital role in cancer postoperative treatment. Strategies to increase the variety of immune cells and their sustainable supply are essential improve therapeutic effect cell-based immunotherapy. Here, inspired by tertiary lymphoid structures (TLSs), we present microfluidic-assisted microporous annealed particle (MAP) scaffold for persistent recruitment diverse therapy. Based on thermochemical responsivity gelatin methacryloyl (GelMA), MAP was fabricated physical cross-linking sequential photo-cross-linking GelMA droplets, which were prepared microfluidic electrospraying. Due encapsulation liquid nitrogen-inactivated tumor immunostimulant, generated could recruit large number cells, involving T macrophages, dendritic B natural killer thereby forming biomimetic TLSs vivo. In addition, combination checkpoint inhibitors, synergistic anticancer response provoked inhibit recurrence metastasis. These properties make proposed scaffold-based artificial great value efficient
Language: Английский
Citations
4