Advances in epigenetics link genetics to the environment and disease

Nature, Journal Year: 2019, Volume and Issue: 571(7766), P. 489 - 499

Published: July 1, 2019

Language: Английский

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The role of 3D genome organization in development and cell differentiation

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(9), P. 535 - 550

Published: June 13, 2019

Language: Английский

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Mechanisms regulating zygotic genome activation

Nature Reviews Genetics, Journal Year: 2018, Volume and Issue: 20(4), P. 221 - 234

Published: Dec. 20, 2018

Language: Английский

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The roles of DNA, RNA and histone methylation in ageing and cancer

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(10), P. 573 - 589

Published: July 3, 2019

Language: Английский

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Functions and mechanisms of epigenetic inheritance in animals

Nature Reviews Molecular Cell Biology, Journal Year: 2018, Volume and Issue: 19(12), P. 774 - 790

Published: Nov. 13, 2018

Language: Английский

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Genomic imprinting disorders: lessons on how genome, epigenome and environment interact

Nature Reviews Genetics, Journal Year: 2019, Volume and Issue: 20(4), P. 235 - 248

Published: Jan. 15, 2019

Language: Английский

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RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay

Molecular Cell, Journal Year: 2019, Volume and Issue: 75(6), P. 1188 - 1202.e11

Published: Aug. 6, 2019

Language: Английский

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SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

Nature Genetics, Journal Year: 2019, Volume and Issue: 51(5), P. 844 - 856

Published: April 29, 2019

Language: Английский

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Resetting histone modifications during human parental-to-zygotic transition

Science, Journal Year: 2019, Volume and Issue: 365(6451), P. 353 - 360

Published: July 4, 2019

Histone modifications regulate gene expression and development. To address how they are reprogrammed in human early development, we investigated key histone marks oocytes embryos. Unlike that mouse oocytes, the permissive mark trimethylated H3 lysine 4 (H3K4me3) largely exhibits canonical patterns at promoters oocytes. After fertilization, prezygotic genome activation (pre-ZGA) embryos acquire chromatin widespread H3K4me3 CpG-rich regulatory regions. By contrast, repressive H3K27me3 undergoes global depletion. regions then resolve to either active or repressed states upon ZGA, followed by subsequent restoration of developmental genes. Finally, combining transcriptome maps, revealed transcription circuitry asymmetric patterning during lineage specification. Collectively, our data unveil a priming phase connecting parental-to-zygotic epigenetic transition.

Language: Английский

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Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health

Human Reproduction Update, Journal Year: 2019, Volume and Issue: 25(5), P. 519 - 541

Published: April 8, 2019

A defining feature of sexual reproduction is the transmission genomic information from both parents to offspring. There now compelling evidence that inheritance such genetic accompanied by additional epigenetic marks, or stable heritable not accounted for variations in DNA sequence. The reversible nature marks coupled with multiple rounds reprogramming erase majority existing patterns have made investigation this phenomenon challenging. However, continual advances molecular methods are allowing closer examination dynamic alterations histone composition and methylation accompany development and, particular, how these modifications can occur an individual's germline be transmitted following generation. While underlying mechanisms permit form transgenerational remain unclear, it increasingly apparent a combination plays major roles determining phenotypes individuals their offspring.Information pertaining was systematically reviewed focusing primarily on mammalian cells exclusion plants, due inherent differences means which between generations. effects environmental factors biological processes were determine contribution modulating inheritable phenotypes.Articles indexed PubMed searched using keywords related inheritance, modifications, paternal maternal traits influencing modifications. We sought clarify role events during life cycle mammals provide comprehensive review epigenomic make-up progenitors may phenotype its descendants.We found strong supporting patterns, even non-protein-coding RNA altering producing offspring, humans rodent species. Multiple domains several modification sites resist demethylation endure genome-wide events. Epigenetic integrated into genome shown modulate gene expression activity at enhancer promoter domains, while mutations alter sequence availability binding. Fundamentally, nuclear response factors, ageing, diet toxicant exposure potential become hereditably transmitted.The environment influences health well-being progeny working through introduce spontaneous as well variety changes, including status post-translational histones. In evolutionary terms, changes create phenotypic diversity fuels fires natural selection. rather than being adaptive, variation also generate plethora pathological disease states ranging dominant disorders neurological conditions, schizophrenia autism.

Language: Английский

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