When Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis

Cell Metabolism, Journal Year: 2020, Volume and Issue: 31(3), P. 448 - 471

Published: March 1, 2020

Language: Английский

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Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms

Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(3)

Published: Jan. 15, 2021

The circadian clock and feeding rhythms are both important regulators of rhythmic gene expression in the liver. To further dissect respective contributions clock, we analyzed differential rhythmicity liver tissue samples across several conditions. We developed a statistical method tailored to compare messenger RNA (mRNA) mouse knockout models multiple genes, as well PARbZip output transcription factors (Hlf/Dbp/Tef). Mice were exposed ad libitum or night-restricted under regular light-dark cycles. During feeding, genetic ablation core attenuated rhythmic-feeding patterns, which could be restored by regimen. High-amplitude mRNA wild-type livers driven but also contributed expression, albeit with significantly lower amplitudes. observed that Bmal1 Cry1/2 knockouts differed their residual expression. Differences mean levels between wild types correlated type. Surprisingly, mice, targets more strongly impacted than rhythms, potentially due activity D-box-repressor NFIL3. Genes lost identified indirect targets. Our findings provide insights into diurnal transcriptome regulators. In addition, gained on specific effects feeding-fasting cycle.

Language: Английский

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Roles of circadian clocks in cancer pathogenesis and treatment

Experimental & Molecular Medicine, Journal Year: 2021, Volume and Issue: 53(10), P. 1529 - 1538

Published: Oct. 1, 2021

Abstract Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h rhythms in cellular and bodily functions across nearly all living species. These internal clock systems enable organisms to anticipate respond daily changes their environment a timely manner, optimizing temporal physiology behaviors. Dysregulation of circadian by genetic environmental risk factors increases susceptibility multiple diseases, particularly cancers. A growing number studies have revealed dynamic crosstalk between cancer pathways, providing mechanistic insights into the therapeutic utility treatment. This review will discuss roles pathogenesis, highlighting recent advances chronotherapeutic approaches for improved

Language: Английский

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The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding

Nature Metabolism, Journal Year: 2021, Volume and Issue: 3(6), P. 829 - 842

Published: May 31, 2021

Language: Английский

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Dietary regulation in health and disease

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: July 23, 2022

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan delaying ageing various species such as yeast, drosophila, rodent, primate human. It emerges develop precision-nutrition therapeutics slow age-related biological processes treat diverse diseases. However, nutritive advantages frequently diversify among individuals well organs tissues, which brings challenges this field. In review, we summarize different forms of dietary interventions extensively prescribed improvement disease treatment pre-clinical or clinical. We discuss nutrient-mediated mechanisms including metabolic regulators, metabolism pathways, epigenetic circadian clocks. Comparably, describe diet-responsive effectors by influence endocrinic, immunological, microbial neural states responsible improving health preventing multiple diseases humans. Furthermore, expatiate patterns dietotheroapies, fasting, calorie-restricted diet, ketogenic high-fibre plants-based protein restriction diet with specific reduction amino acids microelements, potentially affecting morbid states. Altogether, emphasize profound nutritional therapy, highlight crosstalk explored critical factors individualized therapeutic approaches predictors.

Language: Английский

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Circadian rhythms and cancers: the intrinsic links and therapeutic potentials

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: March 4, 2022

The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a wide variety of processes including sleep-wake cycles, eating-fasting and activity-rest coordinating the behavior physiology all organs for whole-body homeostasis. Acute disruption may lead to transient discomfort, whereas long-term irregular will result in dysfunction organism, therefore increasing risks numerous diseases especially cancers. Indeed, both epidemiological experimental evidence has demonstrated intrinsic link between dysregulated cancer. Accordingly, rapidly understanding molecular mechanisms rhythms opening new options cancer therapy, possibly by modulating clock. In this review, we first describe general regulators their functions on addition, provide insights into underlying how several types (including sleep-wake, eating-fasting, activity-rest) can drive progression, which expand our development from clock perspective. Moreover, also summarize potential applications treatment, optional therapeutic strategy patients.

Language: Английский

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Transcriptional control of energy metabolism by nuclear receptors

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 23(11), P. 750 - 770

Published: May 16, 2022

Language: Английский

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Understanding light pollution: Recent advances on its health threats and regulations

Journal of Environmental Sciences, Journal Year: 2022, Volume and Issue: 127, P. 589 - 602

Published: June 18, 2022

Language: Английский

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Light modulates glucose metabolism by a retina-hypothalamus-brown adipose tissue axis

Cell, Journal Year: 2023, Volume and Issue: 186(2), P. 398 - 412.e17

Published: Jan. 1, 2023

Language: Английский

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Biologically informed deep learning for explainable epigenetic clocks

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 15, 2024

Abstract Ageing is often characterised by progressive accumulation of damage, and it one the most important risk factors for chronic disease development. Epigenetic mechanisms including DNA methylation could functionally contribute to organismal aging, however key functions biological processes may govern ageing are still not understood. Although age predictors called epigenetic clocks can accurately estimate an individual based on cellular methylation, their models have limited ability explain prediction algorithm behind underlying controlling ageing. Here we present XAI-AGE, a biologically informed, explainable deep neural network model accurate across multiple tissue types. We show that XAI-AGE outperforms first-generation achieves similar results learning-based models, while opening up possibility infer meaningful insights activity pathways other abstract directly from model.

Language: Английский

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