Recent Advances in the Chemical Composition of Propolis

Molecules, Journal Year: 2014, Volume and Issue: 19(12), P. 19610 - 19632

Published: Nov. 26, 2014

Propolis is a honeybee product with broad clinical applications. Current literature describes that propolis collected from plant resins. From systematic database search, 241 compounds were identified in for the first time between 2000 and 2012; they belong to such diverse chemical classes as flavonoids, phenylpropanoids, terpenenes, stilbenes, lignans, coumarins, their prenylated derivatives, showing pattern consistent around 300 previously reported compounds. The characteristics of are linked diversity geographical location, sources bee species.

Language: Английский

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Historical Aspects of Propolis Research in Modern Times

Evidence-based Complementary and Alternative Medicine, Journal Year: 2013, Volume and Issue: 2013, P. 1 - 11

Published: Jan. 1, 2013

Propolis (bee glue) has been known for centuries. The ancient Greeks, Romans, and Egyptians were aware of the healing properties propolis made extensive use it as a medicine. In middle ages was not very popular topic its in mainstream medicine disappeared. However, knowledge medicinal survived traditional folk interest returned Europe together with renaissance theory ad fontes. It only last century that scientists have able to prove is active important our forefathers thought. Research on chemical composition started at beginning twentieth continued after WW II. Advances chromatographic analytical methods enabled separation extraction several components from propolis. At least 180 different compounds identified so far. Its antibacterial, antiseptic, anti-inflammatory, antifungal, anesthetic, confirmed. effectively used treatment dermatological, laryngological, gynecological problems, neurodegenerative diseases, wound healing, burns ulcers. requires further research may lead new discoveries possible applications.

Language: Английский

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Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 131, P. 110622 - 110622

Published: Aug. 17, 2020

Propolis, a resinous material produced by honey bees from plant exudates, has long been used in traditional herbal medicine and is widely consumed as health aid immune system booster. The COVID-19 pandemic renewed interest propolis products worldwide; fortunately, various aspects of the SARS-CoV-2 infection mechanism are potential targets for compounds. entry into host cells characterized viral spike protein interaction with cellular angiotensin-converting enzyme 2 (ACE2) serine protease TMPRSS2. This involves PAK1 overexpression, which kinase that mediates coronavirus-induced lung inflammation, fibrosis, suppression. Propolis components have inhibitory effects on ACE2, TMPRSS2 signaling pathways; addition, antiviral activity proven vitro vivo. In pre-clinical studies, promoted immunoregulation pro-inflammatory cytokines, including reduction IL-6, IL-1 beta TNF-α. monocytes macrophages, well Jak2/STAT3, NF-kB, inflammasome pathways, reducing risk cytokine storm syndrome, major mortality factor advanced disease. also shown promise an treatment comorbidities particularly dangerous patients, respiratory diseases, hypertension, diabetes, cancer. Standardized consistent bioactive properties now available. Given current emergency caused limited therapeutic options, presented promising relevant option safe, easy to administrate orally readily available natural supplement functional food.

Language: Английский

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Phytochemical Constituents, Antioxidant, Cytotoxic, and Antimicrobial Activities of the Ethanolic Extract of Mexican Brown Propolis

Antioxidants, Journal Year: 2020, Volume and Issue: 9(1), P. 70 - 70

Published: Jan. 13, 2020

Propolis is a complex mixture of natural sticky and resinous components produced by honeybees from living plant exudates. Globally, research has been dedicated to studying the biological properties chemical composition propolis various geographical climatic regions. However, data Mexican brown are scant. The antioxidant activity ethanolic extract (EEP) sample collected in México isolated compounds described. Cytotoxic was evaluated central nervous system cervical cancer cell lines. Cytotoxicity EEP C6 line (HeLa, SiHa, CasKi) measured 3-(3,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium (MTT) assay. antibacterial tested using minimum inhibitory concentration (MIC) Twelve known were identified nuclear magnetic resonance spectroscopy (NMR). Additionally, forty volatile means headspace-solid phase microextraction with gas chromatography mass spectrometry time flight analysis (HS-SPME/GC-MS-TOF). main detected include nonanal (18.82%), α-pinene (12.45%), neryl alcohol (10.13%), (8.04%). showed an anti-proliferative effect on glioma cells better than temozolomide, also decreased proliferation viability cells, but its effectiveness lower compared cisplatin.

Language: Английский

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Propolis: chemical diversity and challenges in quality control

Phytochemistry Reviews, Journal Year: 2022, Volume and Issue: 21(6), P. 1887 - 1911

Published: May 24, 2022

Language: Английский

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Production of chitosan-based biodegradable active films using bio-waste enriched with polyphenol propolis extract envisaging food packaging applications

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 213, P. 486 - 497

Published: May 29, 2022

Developing biodegradable active films has been a promising green approach to overcoming global concerns over the environmental pollution and human health caused by plastic utilization. This study aimed develop based on chitosan (CS), produced from waste crayfish (Procambarus clarkii) shells enriched with bioactive extract (5-20%) of propolis (PS) characterize its properties, envisaging food packaging applications. The chromatographic profile PS confirmed richness, 41 phenolic compounds. With increasing addition chitosan, thickness increased 61.7 71.7 μm, causing reduction in light transmission rate, along greenish colour shift. interactions between CS was infrared spectroscopy, at same time that microstructural integrity checked scanning electron microscopy micrographs. findings also showed enhanced thermal stability mechanical properties e.g., tensile modulus, yield strength, stress break. Besides, it improved antioxidant antimicrobial activities. Overall, CS-based composite seem alternative petroleum-based synthetic plastics allowing extend shelf life products due their eco-friendly nature.

Language: Английский

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Propolis: types, composition, biological activities, and veterinary product patent prospecting

Journal of the Science of Food and Agriculture, Journal Year: 2019, Volume and Issue: 100(4), P. 1369 - 1382

Published: Sept. 5, 2019

Propolis is a resinous substance composed of mixture different plant parts and molecules secreted by bees. Chemically, it defined as complex matrix containing biologically active with antibacterial, antifungal, antiviral, antiparasitic, hepatoprotective, immunomodulatory activities. It widely employed in cosmetic formulations pharmaceutical products one the most used natural products. However, effects strength these biological activities depend on chemical profile composition each propolis type. This associated diversity local flora, place period collection, genetics In this context, objective review was to investigate biological, chemical, microbiological properties propolis. A technological prospection also performed patents for designed be animal health. Our investigation shows that literature contains diverse studies dedicated comparing describing therapeutic These demonstrate potential use veterinary medicine, showing applications extracts formulations. there are low number propolis-based registered patent. Thus, development based promising market exploited. © 2019 Society Chemical Industry.

Language: Английский

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Chemical Composition and Antioxidant Activity of Propolis Prepared in Different Forms and in Different Solvents Useful for Finished Products

Foods, Journal Year: 2018, Volume and Issue: 7(3), P. 41 - 41

Published: March 19, 2018

Different products from a unique propolis extract obtained by using various solvents such as hydroalcoholic, glycolic (98% propylene glycol), and glyceric solutions, oil, well in powder form, named ESIT12, were prepared. The molecular composition of the different preparations was evaluated their antioxidant activity determined. All showed quite similar polyphenol comparable percentage even if ESIT12 found to be richer phenolic acids (caffeic, coumaric, ferulic, isoferulic). Overall, flavones flavonols ranged ~20% up ~36% extract, while flavanones diidroflavonols between ~28% ~41%. Besides composition, hydroalcoholic extracts total polyphenols content. When properties determined for four preparations, among them, thus revealing that it is strictly related content whose comparable. To date, very few data are available on information has never been published oil. This study could interest food nutraceutical industries choose suitable conditions produce useful active finished products.

Language: Английский

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Propolis: A natural biomaterial for dental and oral healthcare.

DOAJ (DOAJ: Directory of Open Access Journals), Journal Year: 2017, Volume and Issue: 11(4), P. 265 - 274

Published: Jan. 1, 2017

The field of health has always emphasised on the use natural products for curing diseases. There are varieties (such as silk, herbal tea, chitosan) used today in biomedical application treating a large array systemic product "Propolis" is non-toxic resinous material having beneficial properties such antimicrobial, anticancer, antifungal, antiviral and anti-inflammatory; hence gain attention researchers its potential bio-dental applications. study aims to explore chemistry propolis concerning dental In addition, status scope current future applications have been discussed. This review gives an insight reader about possible modern-day dentistry.

Language: Английский

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Comparative Chemistry of Propolis from Eight Brazilian Localities

Evidence-based Complementary and Alternative Medicine, Journal Year: 2013, Volume and Issue: 2013, P. 1 - 14

Published: Jan. 1, 2013

Propolis is a complex honeybee product with resinous aspect, containing plant exudates and beeswax. Their color, texture, chemical composition vary, depending on the location of hives local flora. The most studied Brazilian propolis green (alecrim-do-campo) type, which contains mainly prenylated phenylpropanoids caffeoylquinic acids. Other types are produced in Brazil, some red others brown, grey, or black. aim present work was to determine profiles alcohol chloroform extracts eight samples propolis, corresponding six regions. Methanol were obtained analyzed by HPLC/DAD/ESI/MS GC/MS. Two recognized among analyzed: (1) black characterized chiefly flavanones glycosyl flavones, stemming from Picos (Piauí state) Pirenópolis (Goiás state); (2) acids, Cabo Verde (Bahia state), Lavras Mira Bela (Minas Gerais Pariquera-Açu Bauru (São Paulo Ponta Grossa (Paraná state). represents first report flavonoids schaftoside (apigenin-8-C-glucosyl-6-C-arabinose) propolis.

Language: Английский

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