Natural Product Communications,
Journal Year:
2015,
Volume and Issue:
10(11)
Published: Nov. 1, 2015
Propolis
is
one
of
the
most
used
natural
products
known
for
centuries
its
beneficial
effects.
Due
to
significant
differences
in
chemical
composition
samples
originating
from
different
geographic
and
climatic
zones
it
crucial
characterize
reliably
each
type
propolis.
This
article
comprises
latest
findings
concerning
poplar
propolis,
i.e.
gives
a
cross
section
composition,
botanical
origin
biological
activity
propolis
order
encourage
further
investigations
that
would
indicate
Oxidative Medicine and Cellular Longevity,
Journal Year:
2017,
Volume and Issue:
2017(1)
Published: Jan. 1, 2017
There
are
several
health
benefits
that
honeybee
products
such
as
honey,
propolis,
and
royal
jelly
claim
toward
various
types
of
diseases
in
addition
to
being
food.
Frontiers in Pharmacology,
Journal Year:
2017,
Volume and Issue:
8
Published: June 28, 2017
Honeybees
produce
honey,
royal
jelly,
propolis,
bee
venom,
pollen,
and
beeswax,
which
potentially
benefit
to
humans
due
the
bioactives
in
them.
Clinical
standardization
of
these
products
is
hindered
by
chemical
variability
depending
on
honeybee
botanical
sources,
but
different
molecules
have
been
isolated
pharmacologically
characterized.
Major
honey
include
phenolics,
methylglyoxal,
jelly
proteins
(MRJPs),
oligosaccharides.
In
there
are
antimicrobial
jelleins
royalisin
peptides,
immunomodulatory
MRJPs,
hydroxy-decenoic
acid
derivatives,
notably
10-hydroxy-2-decenoic
(10-HDA),
with
antimicrobial,
anti-inflammatory,
immunomodulatory,
neuromodulatory,
metabolic
syndrome
preventing,
antiaging
activities.
Propolis
contains
caffeic
phenethyl
ester
(CAPE)
artepillin
C,
specific
Brazilian
antiviral,
anti-inflammatory
anticancer
effects.
Bee
venom
consists
toxic
peptides
like
pain-inducing
melittin,
SK
channel
blocking
apamin,
allergenic
phospholipase
A2.
pollen
vitaminic,
antioxidant
plant
as
well
antiatherosclerotic,
antidiabetic,
hypoglycemic
flavonoids,
unsaturated
fatty
acids,
sterols.
Beeswax
widely
used
cosmetics
makeup.
Given
importance
drug
discovery
from
natural
this
review
aimed
at
providing
an
exhaustive
screening
bioactive
compounds
detected
their
curative
or
adverse
biological
Medicines,
Journal Year:
2018,
Volume and Issue:
5(1), P. 2 - 2
Published: Jan. 3, 2018
Background:
Propolis
consists
of
a
complex
mixture
resinous
substances
collected
by
honeybees
from
different
plant
sources.
The
objective
this
study
was
to
investigate
the
chemical
composition,
biological
activities,
and
synergistic
properties
with
antibiotics
propolis
samples
various
geographic
origins
(Germany,
Ireland,
Czech
Republic).
Methods:
composition
analyzed
Gas
Liquid
Chromatography-Mass
Spectrometry
(GLC-MS)
High-performance
liquid
chromatography
(HPLC).
minimal
inhibitory
concentration
(MIC)
bactericidal
(MBC)
were
evaluated
standard
broth
microdilution
method,
while
interactions
assessed
checkerboard
dilution
time-kill
curve
assays.
Results:
HPLC
GLC-MS
analyses
revealed
that
ethanol
extract
(EEP)
water
extracts
(WEP)
contained
more
than
100
phytochemicals.
most
abundant
compounds
aromatic
alcohols,
acids,
cinnamic
acid
its
esters,
fatty
flavanone
(chrysin).
showed
highest
phenolic
content
(129.83
±
5.9
mg
CAE/g)
followed
Irish
German
propolis.
Furthermore,
exhibited
value
total
flavonoid
(2.86
0.2
QE/g)
antioxidant
activity
(IC50
=
26.45
µg/mL).
All
moderate
antibacterial
effect
against
Gram-positive
microorganisms
MIC
ranging
0.08
mg/mL
2.5
mg/mL.
Moreover,
EEP
Gram-negative
bacteria
between
0.6
5
In
addition,
displayed
antifungal
(MIC
values
0.6-2.5
mg/mL).
results
obtained
time
kill-kinetic
assay
test
two-drug
combinations
such
as
vancomycin,
oxacillin,
levofloxacin
indicate
mainly
drug-resistant
microbial
pathogens
including
MRSA
VRE.
Conclusions:
synergistically
enhanced
efficacy
antibiotics,
especially
those
acting
on
cell
wall
synthesis
(vancomycin
oxacillin)
microorganisms.
Burns & Trauma,
Journal Year:
2015,
Volume and Issue:
3
Published: Jan. 1, 2015
Abstract
Propolis
is
a
resin
produced
by
honeybees
mixing
wax,
pollen,
salivary
secretions,
and
collected
natural
resins.
The
precise
composition
of
propolis
varies
with
the
source,
over
300
chemical
components
belonging
to
flavonoids,
terpenes,
phenolic
acids
have
been
identified
in
propolis.
Moreover,
its
subjected
geographical
location,
botanical
origin,
bee
species.
compounds
focus
many
works
due
their
antimicrobial
anti-inflammatory
activity;
however,
it
now
recognized
that
also
possesses
regenerative
properties.
There
an
increasing
interest
healing
potential
products,
considering
availability
low
cost
these
products.
contains
huge
number
explicate
some
biological
effects
speeds
up
process
widely
used
folk
remedies.
This
review
aims
condense
results
on
mechanism
activity
compounds.
Antibiotics,
Journal Year:
2022,
Volume and Issue:
11(8), P. 1014 - 1014
Published: July 28, 2022
It
is
accepted
that
the
medicinal
use
of
complex
mixtures
plant-derived
bioactive
compounds
more
effective
than
purified
due
to
beneficial
combination
interactions.
However,
synergy
and
antagonism
are
very
difficult
study
in
a
meticulous
fashion
since
most
established
methods
were
designed
reduce
complexity
identify
single
compounds.
This
represents
critical
review
current
scientific
literature
on
combined
effects
extracts/bioactive
A
particular
emphasis
provided
identification
antimicrobial
synergistic
or
antagonistic
combinations
using
recent
metabolomics
elucidation
approaches
identifying
potential
mechanisms
underlie
their
Proven
examples
synergistic/antagonistic
activity
also
discussed.
The
focus
put
challenges,
difficulties,
problems
need
be
overcome
future
perspectives
surrounding
effects.
utilization
from
plant
extracts
as
appropriate
antimicrobials
important
needs
facilitated
by
means
new
technologies
discover
among
them.
Understanding
nature
interactions
between
will
result
development
therapies.
Evidence-based Complementary and Alternative Medicine,
Journal Year:
2020,
Volume and Issue:
2020(1)
Published: Jan. 1, 2020
In
recent
years,
natural
products,
which
originate
from
plants,
animals,
and
fungi,
together
with
their
bioactive
compounds
have
been
intensively
explored
studied
for
therapeutic
potentials
various
diseases
such
as
cardiovascular,
diabetes,
hypertension,
reproductive,
cancer,
neurodegenerative
diseases.
Neurodegenerative
diseases,
including
Alzheimer’s
disease,
Huntington’s
Parkinson’s
amyotrophic
lateral
sclerosis
are
characterized
by
the
progressive
dysfunction
loss
of
neuronal
structure
function
that
resulted
in
cell
death.
Since
multifactorial
pathological
mechanisms
associated
neurodegeneration,
targeting
multiple
actions
neuroprotection
approach,
involves
preventing
death
restoring
to
damaged
neurons,
could
be
promising
strategies
prevention
Natural
products
emerged
potential
neuroprotective
agents
treatment
This
review
focused
on
exert
a
effect
pathologies
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2021,
Volume and Issue:
20(2), P. 2106 - 2145
Published: Jan. 23, 2021
Abstract
The
development
of
active
packaging
films
and
edible
coatings
based
on
biopolymers
natural
bioactive
substances
has
received
increasing
attention
in
recent
years.
Propolis,
also
called
bee
glue,
is
a
resin
substance
collected
by
worker‐bees
from
the
mucilage,
gum,
several
plants.
In
food
industry,
propolis
commonly
extracted
solvents
to
afford
polyphenol‐rich
extract
with
potent
antimicrobial
antioxidant
activities.
prepared
can
be
mixed
biopolymers,
plasticizers,
emulsifiers,
reinforcing
agents
develop
coatings.
functionality
closely
related
type,
harvesting
method,
geographic
origin,
extraction
method
conditions
propolis,
content
composition
polyphenolic
compounds
extract,
presence
other
substances.
Active
impact
physical,
biochemical,
sensory
properties
(e.g.,
fruits,
vegetables,
meat,
fish)
during
storage.
This
review
focuses
advances
extract.
structural
characterization,
functionality,
potential
applications
summarized.
