Industrial Crops and Products, Journal Year: 2013, Volume and Issue: 49, P. 805 - 812
Published: July 24, 2013
Language: Английский
Phytochemistry, Journal Year: 2018, Volume and Issue: 155, P. 1 - 11
Published: July 24, 2018
Language: Английский
Citations
110
Evidence-based Complementary and Alternative Medicine, Journal Year: 2017, Volume and Issue: 2017(1)
Published: Jan. 1, 2017
Although there is evidence of the benefits propolis on human health, vast majority studies have been conducted using animal models. The present study includes chemical characterization and clinical evaluation effects oral administration solution oxidative status modulation lipids in a population Talca, Chile. Chemical propolis, total phenol, flavonoids, antioxidant capacity were determined by ORAC. Identification phenols flavonoids was assessed HPLC-DAD. A double-blind, placebo-controlled trial conducted. Subjects provided informed consent form Bioethics Committee Universidad de Talca approved protocol. Eligible subjects (n = 67) randomized two groups: 35) placebo 32). All evaluated at 0 (baseline), 45, 90 days. In group, we observed that increases HDL-c went from 53.9 ± 11.9 to 65.8 16.7 mg/dL (p < 0.001) baseline Compared subjects, consumption induced net increase GSH levels 0.0001) decrease TBARS for group. Our findings indicate potential use health. appears positive improvement HDL-c, both which contribute reduced risk cardiovascular disease.
Language: Английский
Citations
104
Asian Pacific Journal of Tropical Biomedicine, Journal Year: 2014, Volume and Issue: 4(7), P. 549 - 556
Published: May 13, 2014
To screen crude extracts of propolis, bee pollen and honey from four stingless species [Trigona incisa (T. incisa)], Timia apicalis, Trigona fusco-balteata fuscibasis) native to East Kalimantan, Indonesia for cytotoxic activity against five human cancer cell lines (HepG2, SW620, ChaGo-I, KATO-III BT474). All samples were extracted with methanol, then subpartitioned n-hexane ethyl acetate. Each extract was screened at 20 μg/mL in vitro cytotoxicity the using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. In addition, previously shown bioactive components propolis (apigenin, caffeic acid phenyl ester, kaempferol naringenin) two chemotherapeutic drugs (doxorubicin 5-fluorouracil) used evaluate sensitivity lines. Overall, had higher activities than pollen, but dependent upon extraction solvent, line. Propolis T. apicalis showed highest lowest activity, respectively. Only HepG2 line broadly sensitive extracts. For pure compounds, doxorubicin most cytotoxic, compounds least, ChaGo-I 10 apigenin μg/mL. effective BT474 contain an Further study is required, including isolation characterization active antiproliferative agent(s).
Language: Английский
Citations
103
Journal of the Science of Food and Agriculture, Journal Year: 2017, Volume and Issue: 97(11), P. 3552 - 3558
Published: Jan. 12, 2017
Propolis is a bee product with wide diversity of biological activity. It has complex composition, which dependent on its botanical source. The present study aimed to determine the chemical profile, antioxidant activity and origin two samples propolis type from locations state Rio Grande do Norte (RN, north-east Brazil).The standard characteristics RN are similar or superior internationally marketed Brazilian green propolis. have high activity, corresponding 10% (municipality Afonso Bezerra) 13% Alto Rodrigues) quercetin by 2,2-diphenyl-1-picrylhydrazyl method 15% (both locations) β-carotene discoloration method. High-performance liquid chromatography diode array detection (HPLC-DAD)-electrospray ionization-tandem mass spectrometry analyses revealed that most constituents flavonoids, mainly flavonols chalcones. HPLC-DAD analysis ethanol extracts great similarity between profile shoot apices 'jurema-preta' (Mimosa tenuiflora, Leguminosae, Mimosoideae).'Jurema-preta' likely resin sources property provide promising prospects for introduction this into apicultural market. © 2017 Society Chemical Industry.
Language: Английский
Citations
91
Antioxidants, Journal Year: 2020, Volume and Issue: 9(4), P. 337 - 337
Published: April 20, 2020
There is no systematic report about propolis chemical biodiversity from the Adriatic Sea islands affecting its antioxidant capacity. Therefore, samples Krk, Rab, Pag, Biševo and Korčula were collected. Comprehensive methods used to unlock their biodiversity: headspace solid-phase microextraction (HS-SPME) hydrodistillation (HD) followed by gas chromatography mass spectrometry (GC-MS); Fourier transform mid-infrared spectroscopy (FT-MIR); ultra high performance liquid with diode array detector quadrupole time-of-flight (UHPLC-DAD-QqTOF-MS) DPPH FRAP assay. The volatiles variability enabled differentiation of in 2 groups Mediterranean propolis: non-poplar type (dominated α-pinene) polar (characterized cadinane sesquiterpenes). Spectral variations (FT-MIR) associated phenolics other balsam-related components significant among samples. UHPLC profiles allowed track compounds related different botanical sources such as poplar (pinobanksin esters, esters glycerides phenolic acids, including prenyl derivatives), coniferous trees (labdane, abietane diterpenes) Cistus spp. (clerodane labdane diterpenes, methylated myricetin derivatives). potential determined ranged 2.6–81.6 mg GAE/g assay 0.1–0.8 mmol Fe2+/g. highest activity was observed for Populus origin. phenolic/flavonoid content positively, significantly correlated.
Language: Английский
Citations
74
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10479 - 10479
Published: Sept. 9, 2022
In recent years, interest in natural products such as alternative sources of pharmaceuticals for numerous chronic diseases, including tumors, has been renewed. Propolis, a product collected by honeybees, and polyphenolic/flavonoid propolis-related components modulate all steps the cancer progression process. Anticancer activity propolis its compounds relies on various mechanisms: cell-cycle arrest attenuation cells proliferation, reduction number stem cells, induction apoptosis, modulation oncogene signaling pathways, inhibition matrix metalloproteinases, prevention metastasis, anti-angiogenesis, anti-inflammatory effects accompanied tumor microenvironment (by modifying macrophage activation polarization), epigenetic regulation, antiviral bactericidal activities, gut microbiota, chemotherapy-induced deleterious side effects. Ingredients from also ”sensitize“ to chemotherapeutic agents, likely blocking transcription factor nuclear kappa-light-chain-enhancer activated B (NF-κB). this review, we summarize current knowledge related flavonoids other polyphenolic growth metastasizing ability, discuss possible molecular cellular mechanisms involved inflammatory pathways processes that affect survival, invasion, angiogenesis, metastasis tumor.
Language: Английский
Citations
66
Apidologie, Journal Year: 2021, Volume and Issue: 52(6), P. 1075 - 1097
Published: Oct. 1, 2021
Language: Английский
Citations
57
Revista Brasileira de Farmacognosia, Journal Year: 2011, Volume and Issue: 22(1), P. 208 - 219
Published: Sept. 15, 2011
Many biological properties have been attributed to various types of propolis, including anti-inflammatory, antimicrobial, antioxidant, antitumor, wound healing, and immunomodulatory activities. This article reviewed studies published that investigated the anti-inflammatory activity propolis different origins and/or its isolated components, focusing on mechanisms action underlying this also addressing some aspects effects. The search was performed following databases: PubMed, Science Direct, HighWire Press, Scielo, Google Academics, Research Gate ISI Web Knowledgement. associated with or compounds such as polyphenols (flavonoids, phenolic acids their esters), terpenoids, steroids amino acids. CAPE is most studied compounds. main included inhibition cyclooxygenase consequent prostaglandin biosynthesis, free radical scavenging, nitric oxide synthesis, reduction in concentration inflammatory cytokines immunosuppressive activity. Propolis found exert an vivo vitro models acute chronic inflammation others studies, indicating promising potential agent natural origin a source chemical for development new drugs.
Language: Английский
Citations
97
LWT, Journal Year: 2015, Volume and Issue: 65, P. 261 - 267
Published: Aug. 12, 2015
Language: Английский
Citations
91
Phytochemical Analysis, Journal Year: 2014, Volume and Issue: 26(2), P. 127 - 136
Published: Nov. 6, 2014
Abstract Introduction Propolis is a resinous natural substance collected by honeybees from different plant sources. Due to the presence of various phytochemicals, this bee‐product exhibits numerous biological activities, including anti‐bacterial, anti‐viral, anti‐inflammatory, anti‐oxidant, immunostimulating and anti‐tumour effects. As chemical composition activity propolis depend on its botanical geographical origin, searching for new bioactive substances in types unexplored regions great importance. Objective The aim study evaluation phenolic profile poplar samples order characterise Serbian propolis, identify possible constituents specify components relevant differentiation into two subgroups through simultaneous analysis bud extracts. Methods Ethanolic extracts buds were comprehensively analysed using ultrahigh‐performance liquid chromatography coupled with hybrid mass spectrometry, which combines linear trap quadrupole Orbitrap MS/MS analyser together chemometric methods. Results Extensive fingerprint was achieved first time. Seventy‐five compounds detected. Eight them identified Pattern‐recognition methods applied content ten quantified phenolics verified existence galangin, chrysin pinocembrin as most influential distinguishing factors. Conclusion confirm their affiliation European type according origin. Copyright © 2014 John Wiley & Sons, Ltd.
Language: Английский
Citations
87